Target Details
| UniProt AC | Q9Y6K9 |
|---|---|
| Gene Symbol | IKBKG |
| Protein Name | NF-kappa-B essential modulator |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16516 (CC2-LZ) PF11577 (NEMO) PF18414 (zf_C2H2_10) |
Summary
- Multi-target molecules 13
- Clinical molecules 6
- Avg pChEMBL 6.62
KEGG Pathways (54)
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Primary immunodeficiency
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Viral carcinogenesis
- Yersinia infection
Associated Diseases (6)
Active Molecules (13)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OHOGGIZZDHRWBN
|
7.5 | IC50 | 3 | — | |
OZEUHFQBMMLXLH
|
7.4 | IC50 | 3 | — | |
MRDGEZUUEBHTNO
|
6.8 | IC50 | 3 | — | |
RJXLKDFSBJOHBM
|
6.7 | IC50 | 4 | Yes | |
WHJZGZLLYCQKOO
|
6.7 | IC50 | 3 | — | |
DCEAJJZHQFOWRL
|
6.6 | IC50 | 3 | — | |
BWZJBXAPRCVCKQ
|
6.5 | IC50 | 5 | Yes | |
ALNKZWZEELZRCE
|
6.5 | IC50 | 5 | Yes | |
NMQGPYPYJSEVSC
|
6.3 | IC50 | 4 | Yes | |
GTOXTYNPQZEAIY
|
6.3 | IC50 | 4 | Yes | |
MFZZZRBZKVFGHR
|
6.3 | IC50 | 4 | Yes | |
RHPZNJJJKFQSAG
|
6.3 | IC50 | 3 | — | |
LBJKDVWECYXKJZ
|
6.1 | IC50 | 3 | — |