Target Details
UniProt ACQ9Y4K4
Gene SymbolMAP4K5
Protein NameMitogen-activated protein kinase kinase kinase kinase 5
OrganismHomo sapiens
Entry Name
Organism Category Human
Pfam Domains PF00780 (CNH) PF00069 (Pkinase)
UniProt
Summary
  • Multi-target molecules 280
  • Clinical molecules 35
  • Avg pChEMBL 6.9
Top Co-occurrence Targets
Active Molecules (280)
InChIKey pChEMBL Type Targets Clinical
UHTHHESEBZOYNR 6.3 Kd 66 Yes
DYNHJHQFHQTFTP 6.3 Kd 38 —
AIQDZMUPVYDVLB 6.3 Ki 48 —
CHADTINFLWZSKR 6.3 Ki 26 —
GQGMUKOYILWOIQ 6.3 Ki 25 —
HHSVICUMCOBRPT 6.3 Ki 33 —
HSMUWLLZAZCLHF 6.3 Ki 25 —
JOGKUKXHTYWRGZ 6.3 Ki 28 —
KAKFXRYHYUPXSU 6.3 Ki 16 —
LJKJYKWDLJUZHA 6.3 Ki 24 —
NCPXFACDZCEIQL 6.3 Ki 7 —
OPLHMHMCXQXEQG 6.3 Ki 10 —
QYGMZFLXMWJYRJ 6.3 Ki 14 —
UTQPKPHUIMHAAN 6.3 Ki 22 —
UYGYYOIUVFMGKQ 6.3 Ki 30 —
VSPFURGQAYMVAN 6.3 Ki 17 —
VVEGARMQKNYDID 6.3 Ki 24 —
WUWDLXZGHZSWQZ 6.3 Ki 41 —
XLFYOIVELARSKP 6.3 Ki 33 —
ZGZVRPRSFXRGCF 6.3 Ki 76 —
FFLJVBPCONQSQW 6.3 IC50 8 —
ALKJNCZNEOTEMP 6.3 Kd 55 —
RITAVMQDGBJQJZ 6.3 Kd 43 —
PIQCTGMSNWUMAF 6.2 Kd 137 Yes
PKCDDUHJAFVJJB 6.2 Kd 13 —
GQLWKGVBOIYMTN 6.2 Ki 35 —
HAYYBYPASCDWEQ 6.2 Ki 47 —
HCNIBOQWDVOZKF 6.2 Ki 26 —
HSKVRPZJBMXFDX 6.2 Ki 20 —
IJNGXROUMFEKDB 6.2 Ki 39 —
IZAVTOABECKIDH 6.2 Ki 20 —
LYNBNVBMAGDJRW 6.2 Ki 81 —
NSYXCWYWACQNOH 6.2 Ki 10 —
OQNPAZRZCXFOBC 6.2 Ki 11 —
QXRJBJVCBQSLTA 6.2 Ki 29 —
UGHBIMSDMGHFIE 6.2 Ki 10 —
UUWNXFJBBYAMDT 6.2 Ki 46 —
XJJYJNMNYDNXNO 6.2 Ki 23 —
XZONYYFHQICDAM 6.2 Ki 19 —
ZKHDDJKHTPLPOQ 6.2 Ki 62 —
WPXVVAWAHQHJPF 6.2 IC50 41 —
XKFTZKGMDDZMJI 6.1 Kd 64 Yes
UXXQOJXBIDBUAC 6.1 Kd 21 Yes
BPNUQXPIQBZCMR 6.1 Ki 60 —
GUMBHNMWKMFKRT 6.1 Ki 23 —
HJYHJYGXRBYDIG 6.1 Ki 23 —
ITAJXWHXKVYGCF 6.1 Ki 5 —
MMMPFWNSQKXKDX 6.1 Ki 14 —
MZIOLOXGGOLJMJ 6.1 Ki 12 —
PPCNMZPSQZFFGM 6.1 Ki 8 —
2D structure