Target Details
| UniProt AC | Q9Y243 |
|---|---|
| Gene Symbol | AKT3 |
| Protein Name | RAC-gamma serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00169 (PH) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 321
- Clinical molecules 7
- Avg pChEMBL 7.59
KEGG Pathways (103)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Glucagon signaling pathway
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (321)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KBKHULLGXKATKS
|
7.2 | IC50 | 3 | — | |
DWZCDSLYZDTWQH
|
7.2 | IC50 | 5 | — | |
ILVKGSGRGSOAHZ
|
7.2 | IC50 | 3 | — | |
NLAQVSZYBUGULE
|
7.2 | IC50 | 3 | — | |
ULDXWLCXEDXJGE
|
7.2 | IC50 | 3 | — | |
GUUFGKDRGZJQMO
|
7.2 | IC50 | 3 | — | |
KWQTWTSUJDYVIO
|
7.2 | IC50 | 5 | — | |
SAJJWJQNKYDEPD
|
7.2 | IC50 | 3 | — | |
GRZXWCHAXNAUHY
|
7.1 | IC50 | 3 | — | |
KLSYPIQWMFSSJW
|
7.1 | IC50 | 8 | — | |
OARXLGLBMAHALM
|
7.1 | IC50 | 12 | Yes | |
UCXPQJNZIRTUGH
|
7.1 | IC50 | 4 | — | |
JQNJMCSONBNGHG
|
7.1 | IC50 | 4 | — | |
BPNUQXPIQBZCMR
|
7.1 | Ki | 60 | — | |
GHPFQRTVUDXWCC
|
7.1 | Ki | 35 | — | |
MIKAKZKNMYZLDX
|
7.1 | Ki | 42 | — | |
GDBKJDBGCLFSGA
|
7.1 | IC50 | 4 | — | |
YHHPZWJUTYTTMC
|
7.1 | IC50 | 3 | — | |
HPFBZSZTVRFYHW
|
7.1 | IC50 | 4 | — | |
DESJGFOSPPNXOH
|
7.1 | Kd | 3 | — | |
UHWWJBSCMVJFFQ
|
7.0 | IC50 | 3 | — | |
ZFVUCRLQQJQTLG
|
7.0 | IC50 | 3 | — | |
IDQNLUQAYNKBEW
|
7.0 | IC50 | 4 | — | |
CAIYLCVURWLDCG
|
7.0 | IC50 | 4 | — | |
KAKGFGCTONHQJW
|
6.9 | Ki | 25 | — | |
YXJORAFRRFTOMV
|
6.9 | IC50 | 2 | — | |
OWCPNEJTTGLSQC
|
6.8 | IC50 | 4 | — | |
QZEZRQSYVRLTOY
|
6.8 | IC50 | 3 | — | |
QGYPCOPTJYNXJQ
|
6.8 | IC50 | 4 | — | |
NKGLJTITEFZKAN
|
6.8 | Ki | 35 | — | |
ORUUEFDGYYTXAF
|
6.8 | Ki | 26 | — | |
HKSZLNNOFSGOKW
|
6.8 | Kd | 213 | — | |
ODXGZMFSEOVGAX
|
6.8 | IC50 | 3 | — | |
WFDHLKUQFQCHKF
|
6.8 | IC50 | 6 | — | |
AYCPARAPKDAOEN
|
6.8 | Ki | 73 | — | |
KGZXBIKBYHLVNP
|
6.8 | IC50 | 3 | — | |
NYQLHIXUWWCSBD
|
6.8 | IC50 | 4 | — | |
ZWEGTTQRYSSYLT
|
6.8 | IC50 | 3 | — | |
BPNUQXPIQBZCMR
|
6.7 | Kd | 83 | Yes | |
GQTFJOHRQMWEAZ
|
6.7 | IC50 | 3 | — | |
IPKHSYHXXAIZDD
|
6.7 | Ki | 18 | — | |
RUTSTIXDRLTLKM
|
6.7 | IC50 | 3 | — | |
TXIKLFZDDZQLFG
|
6.7 | IC50 | 2 | — | |
XWAKIYAMWRQWDT
|
6.6 | IC50 | 4 | — | |
UHWWJBSCMVJFFQ
|
6.6 | IC50 | 3 | — | |
HHOVRZGUSBMKKU
|
6.6 | IC50 | 2 | Yes | |
LRZYYIZFBXFSJB
|
6.6 | Ki | 69 | — | |
MVJMMLFMPWITEJ
|
6.6 | Ki | 110 | — | |
OWDRQHVEJIYVOI
|
6.6 | Ki | 47 | — | |
SBFPHSVZEXSHTL
|
6.6 | Ki | 62 | — |