Target Details
| UniProt AC | Q9UHD2 |
|---|---|
| Gene Symbol | TBK1 |
| Protein Name | Serine/threonine-protein kinase TBK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) PF18394 (TBK1_CCD1) PF18396 (TBK1_ULD) |
Summary
- Multi-target molecules 639
- Clinical molecules 19
- Avg pChEMBL 7.59
KEGG Pathways (25)
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- Autophagy - animal
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Pathways of neurodegeneration - multiple diseases
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Shigellosis
- Toll-like receptor signaling pathway
- Yersinia infection
Associated Diseases (3)
Active Molecules (639)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AYCPARAPKDAOEN
|
6.4 | Kd | 73 | — | |
RTLYKZQELDVJNY
|
6.4 | IC50 | 2 | — | |
KEZNARMJBJOFQB
|
6.4 | IC50 | 2 | — | |
PBCZSGKMGDDXIJ
|
6.4 | Kd | 68 | Yes | |
FEWKHURGVUMFHP
|
6.4 | IC50 | 2 | — | |
MHWHPWMWKYXCRJ
|
6.4 | Ki | 32 | — | |
BBJKFMYLMLVUDU
|
6.4 | IC50 | 2 | — | |
WXNQCJRSDVNYKO
|
6.4 | IC50 | 2 | — | |
CMRSPQFHPQBQIK
|
6.4 | IC50 | 2 | — | |
CJNKBAKWQGYGIS
|
6.4 | IC50 | 4 | — | |
DKZYXHCYPUVGAF
|
6.3 | Kd | 112 | — | |
JQSSJNGHYKCXQI
|
6.3 | IC50 | 2 | — | |
VWJJCQKYLQGLKH
|
6.3 | IC50 | 2 | — | |
VWWBXTRZUJUTHA
|
6.3 | IC50 | 2 | — | |
BIIVYFLTOXDAOV
|
6.3 | Kd | 82 | Yes | |
GUBJNPWVIUFSTR
|
6.3 | Kd | 103 | — | |
QQWUGDVOUVUTOY
|
6.3 | Kd | 231 | Yes | |
RITAVMQDGBJQJZ
|
6.3 | IC50 | 43 | — | |
UBPYILGKFZZVDX
|
6.3 | IC50 | 130 | Yes | |
ALNFAQPPDFVBLE
|
6.3 | IC50 | 2 | — | |
GCIKSSRWRFVXBI
|
6.3 | Kd | 109 | Yes | |
MRXMSGWSWWMSMF
|
6.3 | IC50 | 2 | — | |
UJBJWYNPUOLFIZ
|
6.3 | Ki | 49 | — | |
ZCBUQCWBWNUWSU
|
6.3 | Ki | 11 | — | |
ZGDYBJXDIXVTLV
|
6.3 | Ki | 54 | — | |
NHEUUFMAYLMPKA
|
6.3 | IC50 | 2 | — | |
ZSPQUICTVOBVJJ
|
6.3 | IC50 | 4 | — | |
ZVBIBRJWIINCLT
|
6.3 | IC50 | 2 | — | |
IUYVWTVARMTLCH
|
6.3 | IC50 | 2 | — | |
QOJSERWVVHZZPL
|
6.3 | IC50 | 3 | — | |
AGRUJTXFZAUTCB
|
6.3 | IC50 | 2 | — | |
BMPKLAIDXFLOJP
|
6.3 | IC50 | 2 | — | |
CYKQBRKJEQQTHD
|
6.3 | IC50 | 2 | — | |
HDPFOBSEWXADBZ
|
6.3 | IC50 | 2 | — | |
HSTCZBIJGXTJBW
|
6.3 | IC50 | 2 | — | |
MBMXQMPCISCAST
|
6.3 | IC50 | 2 | — | |
NGRIQWBQAPFNJW
|
6.3 | IC50 | 2 | — | |
PMXKKMZIBVSKTC
|
6.3 | IC50 | 2 | — | |
RHAHFLIAPLIWKN
|
6.3 | IC50 | 2 | — | |
ZQAHHQOAUDLNLW
|
6.3 | IC50 | 2 | — | |
DWLMLPCWSGBXMZ
|
6.2 | IC50 | 6 | Yes | |
GJVSHKMQEGTVTJ
|
6.2 | IC50 | 2 | — | |
JJEHKOXQJFSVQK
|
6.2 | IC50 | 2 | — | |
OLVBAUVSICCWEJ
|
6.2 | Ki | 39 | — | |
SGSXSDRBQOSVBH
|
6.2 | IC50 | 2 | — | |
WWRBLGBEFCCCCB
|
6.2 | IC50 | 2 | — | |
DSXXEELGXBCYNQ
|
6.2 | IC50 | 28 | Yes | |
DYIBUWLFYBFBBS
|
6.2 | IC50 | 5 | — | |
KTEIFNKAUNYNJU
|
6.2 | Kd | 114 | — | |
NTPAYIOIMIUCMN
|
6.1 | IC50 | 4 | — |