Target Details
| UniProt AC | Q9UHD2 |
|---|---|
| Gene Symbol | TBK1 |
| Protein Name | Serine/threonine-protein kinase TBK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) PF18394 (TBK1_CCD1) PF18396 (TBK1_ULD) |
Summary
- Multi-target molecules 639
- Clinical molecules 19
- Avg pChEMBL 7.59
KEGG Pathways (25)
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- Autophagy - animal
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Pathways of neurodegeneration - multiple diseases
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Shigellosis
- Toll-like receptor signaling pathway
- Yersinia infection
Associated Diseases (3)
Active Molecules (639)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MERPPDGMBNDZGS
|
6.7 | IC50 | 2 | — | |
MHPBLCYPFBBOND
|
6.7 | IC50 | 6 | — | |
OEZHSZIDGUKBRK
|
6.7 | IC50 | 10 | — | |
FUIFXIHDSHGQPX
|
6.7 | IC50 | 2 | — | |
GLXBQRZXUMNQRW
|
6.7 | IC50 | 2 | — | |
VNDWQCSOSCCWIP
|
6.7 | Ki | 39 | Yes | |
WQFGNANQTYLQBP
|
6.7 | Ki | 16 | — | |
YJYNURQSPOYQLL
|
6.7 | IC50 | 2 | — | |
HTIICNKYFZGUBY
|
6.6 | IC50 | 2 | — | |
IZDUBCLXNXGBOL
|
6.6 | IC50 | 2 | — | |
JJNQVVXLJXQVLY
|
6.6 | IC50 | 2 | — | |
QDJHWYVWXZCCGP
|
6.6 | IC50 | 2 | — | |
DCRFLNHKMKYMQP
|
6.6 | IC50 | 2 | — | |
ISADMOXHYKRVEW
|
6.6 | IC50 | 2 | — | |
BBLUCKCGFGRHBM
|
6.6 | Kd | 5 | — | |
BHMSKCZYCFPYKC
|
6.6 | IC50 | 2 | — | |
NLPNLVFDNONUOB
|
6.6 | IC50 | 2 | — | |
XXDNMKSTCJGGQP
|
6.6 | IC50 | 2 | — | |
YFHGVXAURSKWLJ
|
6.6 | IC50 | 2 | — | |
LTKDDAVQVRFMKQ
|
6.6 | IC50 | 2 | — | |
ZNBXHMDTLSAOFO
|
6.6 | IC50 | 2 | — | |
HDOTZQLJXWSXIO
|
6.6 | IC50 | 2 | — | |
XNLQEOMWHKGKJO
|
6.6 | IC50 | 2 | — | |
DFZQZSMWFHQAPD
|
6.6 | IC50 | 2 | — | |
BUOPARGTGBRMBL
|
6.5 | IC50 | 2 | — | |
IQRLNHJUFLQKGU
|
6.5 | IC50 | 2 | — | |
XKTUKRBLWOHYIL
|
6.5 | IC50 | 4 | — | |
NHSSQLZJTUWHPU
|
6.5 | IC50 | 2 | — | |
UDNWHJPQDRSGDI
|
6.5 | IC50 | 2 | — | |
FJJRVGSILLVPKU
|
6.5 | IC50 | 2 | — | |
IUSHILFEMDZEFI
|
6.5 | IC50 | 2 | — | |
IMXLNRXFUOHHDN
|
6.5 | IC50 | 2 | — | |
IXANCEFCAMWOSC
|
6.5 | IC50 | 2 | — | |
QYKSYJHYCDJRQT
|
6.5 | IC50 | 2 | — | |
GJOXRIYWDHESDF
|
6.5 | Ki | 27 | — | |
JJGSOVIZOMZMCS
|
6.5 | Ki | 35 | — | |
JNXJKTXDSPWNRP
|
6.5 | Ki | 30 | — | |
UIRCQOKSJDLYBB
|
6.5 | Ki | 50 | — | |
PJLYZTYJSMPZHT
|
6.5 | IC50 | 2 | — | |
CLVOFVSKXGTJMX
|
6.5 | IC50 | 2 | — | |
DWBFATQGRAYQFC
|
6.5 | IC50 | 2 | — | |
YSJYNAPMKLZIGV
|
6.5 | IC50 | 2 | — | |
ZSZOBRBJIJWWHH
|
6.5 | IC50 | 4 | — | |
NBXRQAXVXWKQJZ
|
6.5 | IC50 | 2 | — | |
OMSMAWMALYCJCB
|
6.5 | IC50 | 2 | — | |
RURLEFVQRJFOOD
|
6.5 | IC50 | 2 | — | |
CIKDZQBTQZZADZ
|
6.4 | IC50 | 3 | — | |
ZTLALBZROUPCEA
|
6.4 | IC50 | 2 | — | |
RFYVLIYJZUYOAT
|
6.4 | IC50 | 2 | — | |
AFZREGWWRXQGGC
|
6.4 | IC50 | 2 | — |