Target Details
| UniProt AC | Q9UHD2 |
|---|---|
| Gene Symbol | TBK1 |
| Protein Name | Serine/threonine-protein kinase TBK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) PF18394 (TBK1_CCD1) PF18396 (TBK1_ULD) |
Summary
- Multi-target molecules 639
- Clinical molecules 19
- Avg pChEMBL 7.59
KEGG Pathways (25)
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- Autophagy - animal
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Pathways of neurodegeneration - multiple diseases
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Shigellosis
- Toll-like receptor signaling pathway
- Yersinia infection
Associated Diseases (3)
Active Molecules (639)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NZELJWLQMFWZDX
|
7.0 | IC50 | 2 | — | |
WZWSPTDKPFXDGL
|
7.0 | IC50 | 2 | — | |
LHXLDDHQDUKPIM
|
6.9 | IC50 | 3 | — | |
PEGMEQCMRMUMBG
|
6.9 | IC50 | 2 | — | |
SSAAGCQGRIMQSH
|
6.9 | IC50 | 2 | — | |
HPYDIJUSTZXNRN
|
6.9 | IC50 | 2 | — | |
MJTMCXPFKSSYRZ
|
6.9 | IC50 | 2 | — | |
PNYUSFRZJAPJCP
|
6.9 | IC50 | 2 | — | |
QNONXXVGNAZLMI
|
6.9 | IC50 | 2 | — | |
UEESRKKBPBMNHE
|
6.9 | IC50 | 2 | — | |
UOPCRSIUYMGQCP
|
6.9 | IC50 | 6 | — | |
WINHZLLDWRZWRT
|
6.9 | Kd | 201 | Yes | |
YYPXOMDDWZLVDO
|
6.9 | IC50 | 2 | — | |
ZIRAJQJDABKSFH
|
6.9 | IC50 | 2 | — | |
RGNHKJWHFIPHIM
|
6.9 | Ki | 66 | — | |
GVEFUAPLXFCYLH
|
6.9 | IC50 | 2 | — | |
MJBVMFNLYNJFSW
|
6.9 | IC50 | 2 | — | |
NKTGILZAOLEZPR
|
6.9 | IC50 | 2 | — | |
PIQCTGMSNWUMAF
|
6.9 | Kd | 137 | Yes | |
SPYTVKZEORYOEZ
|
6.9 | IC50 | 2 | — | |
YEEWXIVVPABJAB
|
6.9 | IC50 | 2 | — | |
YYLKKYCXAOBSRM
|
6.9 | Kd | 191 | — | |
BNVGYGOBIHDVET
|
6.9 | IC50 | 4 | — | |
VCZRYZZCLOMGOV
|
6.9 | IC50 | 4 | — | |
VLGIYSJSJHPDHN
|
6.9 | IC50 | 5 | — | |
CGELHDCKISPXTF
|
6.8 | IC50 | 2 | — | |
XAJOPTJESFDNGL
|
6.8 | IC50 | 2 | — | |
YXNUVQPEHUKSLS
|
6.8 | IC50 | 2 | — | |
LSYVMTFICMPMTL
|
6.8 | IC50 | 2 | — | |
FEPKNBFNXRIIAB
|
6.8 | IC50 | 2 | — | |
FXOQQOTXASSILN
|
6.8 | IC50 | 2 | — | |
SIVPOEPNFMZRLH
|
6.8 | IC50 | 2 | — | |
XZXHXSATPCNXJR
|
6.8 | Kd | 165 | Yes | |
ZZSBPGIGIUFJRA
|
6.8 | Kd | 46 | — | |
BLQYVHBZHAISJM
|
6.8 | Ki | 54 | — | |
CTNPALGJUAXMMC
|
6.8 | Kd | 151 | — | |
FFPHMUIGESPOTK
|
6.8 | IC50 | 6 | — | |
HEUSUIRCBWROMH
|
6.8 | Ki | 64 | — | |
QNULKTUETCUJKC
|
6.8 | IC50 | 14 | Yes | |
RWJIWEQYLOKEBO
|
6.8 | IC50 | 2 | — | |
VSGIYMAWHNSRDN
|
6.8 | IC50 | 2 | — | |
ZUDLFDOJAKMMDT
|
6.8 | IC50 | 2 | — | |
ZHLODYGHLUYMDJ
|
6.8 | IC50 | 7 | — | |
GCYXEGSPUDSZJY
|
6.8 | IC50 | 17 | Yes | |
KPJNILHFVBUXEY
|
6.8 | IC50 | 2 | — | |
LTYGAJVXAFJKSY
|
6.8 | IC50 | 3 | Yes | |
BTUAQQDZVLCPFW
|
6.7 | IC50 | 2 | — | |
FQMQKRIYLONZDU
|
6.7 | IC50 | 2 | — | |
PUFFLYGGNSKHRQ
|
6.7 | IC50 | 2 | — | |
CYSDRDWNFDQHMX
|
6.7 | IC50 | 2 | — |