Target Details
| UniProt AC | Q9UBS0 |
|---|---|
| Gene Symbol | RPS6KB2 |
| Protein Name | Ribosomal protein S6 kinase beta-2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 13
- Clinical molecules 1
- Avg pChEMBL 7.56
KEGG Pathways (31)
- AMPK signaling pathway
- Acute myeloid leukemia
- Apelin signaling pathway
- Autophagy - animal
- Breast cancer
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- ErbB signaling pathway
- Fc gamma R-mediated phagocytosis
- Gastric cancer
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Proteoglycans in cancer
- Shigellosis
- TGF-beta signaling pathway
- Thermogenesis
- mTOR signaling pathway
Active Molecules (13)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HKSZLNNOFSGOKW
|
8.8 | IC50 | 408 | — | |
CXLUKIBRYMSSPZ
|
8.3 | IC50 | 2 | — | |
FYXRSVDHGLUMHB
|
8.2 | IC50 | 8 | — | |
MHGPJIHGGLSWFD
|
8.1 | IC50 | 8 | — | |
IEQAHFTVGLZUBI
|
8.0 | IC50 | 8 | — | |
IIRWNGPLJQXWFJ
|
7.9 | IC50 | 21 | — | |
IRKXKBMGTVDZAJ
|
7.7 | IC50 | 3 | — | |
RSFBRAHCHZGZPB
|
7.5 | IC50 | 8 | — | |
GXGUVSXXUOACEX
|
7.4 | IC50 | 2 | — | |
YOBIWCLAYQWPPW
|
7.2 | IC50 | 23 | — | |
HIUHVDROHDSKTC
|
7.0 | Ki | 20 | — | |
PROGKLMIRQVLRO
|
6.1 | IC50 | 12 | — | |
WHWRHSZXRYNDDO
|
6.0 | IC50 | 8 | Yes |