Target Details
| UniProt AC | Q9NWZ3 |
|---|---|
| Gene Symbol | IRAK4 |
| Protein Name | Interleukin-1 receptor-associated kinase 4 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 431
- Clinical molecules 21
- Avg pChEMBL 7.37
KEGG Pathways (22)
- Alcoholic liver disease
- Chagas disease
- Coronavirus disease - COVID-19
- Epstein-Barr virus infection
- Hepatitis B
- Herpes simplex virus 1 infection
- Human immunodeficiency virus 1 infection
- Influenza A
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Pathogenic Escherichia coli infection
- Pertussis
- Salmonella infection
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Yersinia infection
Associated Diseases (1)
Active Molecules (431)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
TXXHHAICAYYMLP
|
9.8 | Kd | 2 | — | |
IZGFZDZKZXRBQZ
|
9.7 | IC50 | 2 | — | |
JKDGKIBAOAFRPJ
|
9.7 | IC50 | 3 | — | |
UBZCBNADOGDNJL
|
9.7 | Kd | 2 | — | |
JJZLDWBCAMPSMG
|
9.6 | IC50 | 3 | — | |
CKFOAVDINFHZIR
|
9.5 | Kd | 2 | — | |
JQMIRXOVVPAXPB
|
9.4 | Kd | 2 | — | |
FPHKCZOCTJCWAD
|
9.4 | Kd | 2 | — | |
UUTHPYJPFVUVPN
|
9.4 | Ki | 3 | — | |
FTEUGWHCWRSIJU
|
9.2 | IC50 | 3 | — | |
IGZHZHVJEZFVIH
|
9.2 | IC50 | 2 | — | |
KPKVXBUKMZIGPN
|
9.2 | IC50 | 3 | — | |
QSSMDRNGJZDMSQ
|
9.2 | IC50 | 3 | — | |
RZHTUCWWEKMCNM
|
9.2 | IC50 | 2 | — | |
ZEMQCNHEKKILBX
|
9.2 | IC50 | 3 | — | |
ZRZMENVDJBJBOY
|
9.2 | IC50 | 3 | — | |
CKFOAVDINFHZIR
|
9.2 | Kd | 2 | — | |
SIVKMVMSQFNJAG
|
9.2 | Kd | 2 | — | |
ZQKNIPQNEVNCDY
|
9.2 | IC50 | 8 | — | |
INCVUGCZQZUSSU
|
9.2 | Kd | 2 | — | |
KQDKXYWFBHTGIX
|
9.2 | IC50 | 2 | — | |
DIZQXPLWZKQART
|
9.2 | IC50 | 2 | — | |
FLXHMSFCIMZSJT
|
9.2 | IC50 | 3 | — | |
GPQARSZTOBDAFR
|
9.2 | IC50 | 2 | — | |
GZNUMHPRTTZGTC
|
9.2 | IC50 | 3 | — | |
IQBCZHKBLZWXEM
|
9.2 | IC50 | 3 | — | |
JOGIYNFTOOGHNQ
|
9.2 | IC50 | 3 | — | |
MCOWNEICYXDEPL
|
9.2 | IC50 | 3 | — | |
QITLDLOFVQLFFF
|
9.2 | IC50 | 2 | — | |
QPKFIZDVDMZSPR
|
9.2 | Ki | 3 | — | |
SRCLLEDPPXOXGH
|
9.2 | IC50 | 3 | — | |
AKLWVZFHNFDHCQ
|
9.1 | IC50 | 3 | — | |
IALDYVNFZAPNJV
|
9.1 | IC50 | 11 | — | |
MMKIEBBLOVSLAS
|
9.1 | IC50 | 3 | — | |
SNNSTEZDXSIKQW
|
9.1 | IC50 | 3 | — | |
STCDSEJQOLKGFJ
|
9.1 | IC50 | 2 | — | |
HTJGFHHVVPNDMR
|
9.1 | IC50 | 6 | — | |
UXNHXSBDEPPEKO
|
9.0 | IC50 | 2 | — | |
BNVZRFQNZWYPQH
|
9.0 | IC50 | 2 | — | |
CFBKGVOKLIQQJD
|
9.0 | IC50 | 3 | — | |
CZYCPCNQYXFAPQ
|
9.0 | IC50 | 2 | — | |
FRKBJIBHJMIOHI
|
9.0 | IC50 | 2 | — | |
GJMNFLBPIHSIRV
|
9.0 | IC50 | 2 | — | |
HXJNPTQRPZSTHS
|
9.0 | IC50 | 2 | — | |
HXQKDULUOFXHDI
|
9.0 | IC50 | 2 | — | |
JOBAEWAZUAPIKW
|
9.0 | IC50 | 2 | — | |
KZVISSXNPKKESH
|
9.0 | IC50 | 3 | — | |
NAMQQRIYZTTYCJ
|
9.0 | IC50 | 2 | — | |
PDXCPPIXNVTKCI
|
9.0 | IC50 | 2 | — | |
RKSPQOPBECGSGM
|
9.0 | IC50 | 3 | — |