Target Details
| UniProt AC | Q99683 |
|---|---|
| Gene Symbol | MAP3K5 |
| Protein Name | Mitogen-activated protein kinase kinase kinase 5 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF19039 (ASK_PH) PF20309 (DRHyd-ASK) PF20302 (HisK-N-like) PF13281 (MAP3K_TRAF_bd) PF00069 (Pkinase) |
Summary
- Multi-target molecules 81
- Clinical molecules 3
- Avg pChEMBL 7.95
KEGG Pathways (20)
- Alcoholic liver disease
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apoptosis
- Chemical carcinogenesis - reactive oxygen species
- Fluid shear stress and atherosclerosis
- Huntington disease
- Lipid and atherosclerosis
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Parkinson disease
- Pathways of neurodegeneration - multiple diseases
- Platinum drug resistance
- Protein processing in endoplasmic reticulum
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- TNF signaling pathway
- Thermogenesis
- Tight junction
Active Molecules (81)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SMJAMOAYGIVKRI
|
7.8 | IC50 | 4 | — | |
FDGHCHUHLVBKLS
|
7.8 | IC50 | 2 | — | |
UBSRPCYTKJDJKN
|
7.5 | IC50 | 2 | — | |
GSYUZRLLPWNNAL
|
7.5 | IC50 | 6 | — | |
ANCZNPGQXFLAIW
|
7.4 | IC50 | 3 | — | |
RLTVBHOYTGZPMF
|
7.4 | IC50 | 2 | — | |
FKDNUEBNRIFBDZ
|
7.3 | IC50 | 3 | — | |
HKSZLNNOFSGOKW
|
7.3 | IC50 | 118 | — | |
CMWRPDHVGMHLSZ
|
7.2 | IC50 | 22 | — | |
NWXGFDVFXJMUDD
|
7.2 | IC50 | 5 | — | |
HKSZLNNOFSGOKW
|
7.2 | IC50 | 408 | — | |
QTEKWFKGOIRYGW
|
7.2 | IC50 | 2 | — | |
UIARLYUEJFELEN
|
7.2 | Kd | 289 | Yes | |
ZCCPLJOKGAACRT
|
7.0 | Kd | 599 | — | |
MWKSRKSEWLRPBL
|
7.0 | Kd | 1075 | — | |
HKSZLNNOFSGOKW
|
7.0 | IC50 | 49 | Yes | |
NXSJMRCTGYTSTK
|
6.9 | Kd | 200 | — | |
ATBAETXFFCOZOY
|
6.8 | IC50 | 39 | — | |
ATBAETXFFCOZOY
|
6.8 | IC50 | 10 | — | |
KOZFSFOOLUUIGY
|
6.7 | Kd | 88 | Yes | |
OSVUGUHRKMMBSE
|
6.6 | Kd | 170 | — | |
ATUUNJCZCOMUKD
|
6.4 | IC50 | 7 | — | |
JMWUINDPNXOLQK
|
6.2 | IC50 | 2 | — | |
SADRMVXUFCEHJG
|
6.2 | IC50 | 2 | — | |
ZRXIUWDFOIRCIZ
|
6.1 | IC50 | 3 | — | |
PTQKRNULLCXNRU
|
6.1 | IC50 | 4 | — | |
DKZYXHCYPUVGAF
|
6.1 | Kd | 112 | — | |
GXZFDXZCJALHRF
|
6.0 | IC50 | 6 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — |