Target Details
| UniProt AC | Q99683 |
|---|---|
| Gene Symbol | MAP3K5 |
| Protein Name | Mitogen-activated protein kinase kinase kinase 5 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF19039 (ASK_PH) PF20309 (DRHyd-ASK) PF20302 (HisK-N-like) PF13281 (MAP3K_TRAF_bd) PF00069 (Pkinase) |
Summary
- Multi-target molecules 81
- Clinical molecules 3
- Avg pChEMBL 7.95
KEGG Pathways (20)
- Alcoholic liver disease
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apoptosis
- Chemical carcinogenesis - reactive oxygen species
- Fluid shear stress and atherosclerosis
- Huntington disease
- Lipid and atherosclerosis
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Parkinson disease
- Pathways of neurodegeneration - multiple diseases
- Platinum drug resistance
- Protein processing in endoplasmic reticulum
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- TNF signaling pathway
- Thermogenesis
- Tight junction
Active Molecules (81)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HOYJVUGIPWXZQG
|
9.4 | IC50 | 2 | — | |
UTWWORAHCAYQGO
|
9.1 | IC50 | 2 | — | |
SGSIUCNJMVKMOM
|
9.0 | IC50 | 2 | — | |
GXPOETDGLYYIAQ
|
8.9 | IC50 | 2 | — | |
UNFXQAIBILVROM
|
8.9 | IC50 | 2 | — | |
IXEYSARKPAVONO
|
8.8 | IC50 | 2 | — | |
ULTLESSHPPQKCA
|
8.8 | IC50 | 2 | — | |
AVSWNWJPSPLXLT
|
8.8 | IC50 | 2 | — | |
KRYLADYSTZJSPE
|
8.8 | IC50 | 2 | — | |
VPHMCGNTEDIZJX
|
8.8 | IC50 | 2 | — | |
DLDZDZXEDKRYGO
|
8.7 | IC50 | 2 | — | |
UNYRWSBHWKLEPE
|
8.7 | IC50 | 2 | — | |
XWAWCQYTWRWPDA
|
8.7 | IC50 | 2 | — | |
FOEIQLJTWGNMAF
|
8.7 | IC50 | 2 | — | |
HBEJNSXVGAQKPV
|
8.7 | IC50 | 2 | — | |
MLKBIPNUPIWFRD
|
8.7 | IC50 | 2 | — | |
OLVJZBVBICDNDZ
|
8.7 | IC50 | 2 | — | |
UVUZEPPXWNQQIU
|
8.7 | IC50 | 2 | — | |
CWJRIYQTZCOZMG
|
8.7 | IC50 | 2 | — | |
MRKVWLRJTICKRW
|
8.7 | IC50 | 2 | — | |
HUOHJWLXQDDAQX
|
8.7 | IC50 | 2 | — | |
SGVJPVKLEKYAJI
|
8.7 | IC50 | 2 | — | |
IGIYTPHNJWHEHH
|
8.7 | IC50 | 2 | — | |
LCFPCLKTQXMUGV
|
8.7 | IC50 | 2 | — | |
QRWVAFRLJZTAJZ
|
8.7 | IC50 | 2 | — | |
ZDAMMZVKCIUPQN
|
8.7 | IC50 | 2 | — | |
FUIPXUTXHGPFCR
|
8.6 | IC50 | 2 | — | |
JCNKIUAZQBRFLI
|
8.6 | IC50 | 2 | — | |
LMCHECNDQKZNCD
|
8.6 | IC50 | 2 | — | |
RUMKPGLTVNIODO
|
8.6 | IC50 | 2 | — | |
MUZYCIOUSKICFY
|
8.6 | IC50 | 2 | — | |
DWYBGTYDUKJJIY
|
8.6 | IC50 | 2 | — | |
GMPZDJRNJKFIAT
|
8.6 | IC50 | 2 | — | |
FCAMTRIQYPAGBH
|
8.6 | IC50 | 2 | — | |
AFELNRHIXXVTNY
|
8.6 | IC50 | 2 | — | |
UZZFEAONZIHMSX
|
8.6 | IC50 | 2 | — | |
GGXVCKICZMCCLV
|
8.6 | IC50 | 2 | — | |
RMDQTUKUWQKGFZ
|
8.6 | IC50 | 2 | — | |
VWVSGSNEMFMEAE
|
8.6 | IC50 | 2 | — | |
MUAQRESRLYYNEV
|
8.5 | IC50 | 2 | — | |
VOMQQXSMYIYUPK
|
8.5 | IC50 | 2 | — | |
DURJLTKEXQILNU
|
8.5 | IC50 | 2 | — | |
NHHMVQGTXMGSAE
|
8.5 | IC50 | 2 | — | |
LUQKIXFXOFQGGI
|
8.5 | IC50 | 2 | — | |
RHBNPXMMGYHEMX
|
8.4 | IC50 | 2 | — | |
ZLOBOPFIUGIVMK
|
8.4 | IC50 | 2 | — | |
RBWSGKOQHNYLTK
|
8.3 | IC50 | 2 | — | |
YISMQBFJYDFMAL
|
8.2 | IC50 | 46 | — | |
NDBJFFCSTXBTFV
|
7.9 | IC50 | 6 | — | |
GTMDADVBDVQONE
|
7.8 | IC50 | 2 | — |