Target Details
| UniProt AC | Q92569 |
|---|---|
| Gene Symbol | PIK3R3 |
| Protein Name | Phosphatidylinositol 3-kinase regulatory subunit gamma |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16454 (PI3K_P85_iSH2) PF00017 (SH2) |
Summary
- Multi-target molecules 289
- Clinical molecules 0
- Avg pChEMBL 6.75
KEGG Pathways (106)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Active Molecules (289)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QWRWABZPKBNWJW
|
6.6 | IC50 | 8 | — | |
KWRMMGQBGIIMIQ
|
6.6 | IC50 | 8 | — | |
BQQOJYRNJKJNIK
|
6.6 | IC50 | 8 | — | |
YYLPYSXYKVBLBD
|
6.6 | IC50 | 8 | — | |
BSQLGIZDXTZOLY
|
6.5 | IC50 | 8 | — | |
CENMCUFOZLPPKP
|
6.5 | IC50 | 8 | — | |
XGBDKCNPCGGPBO
|
6.5 | IC50 | 8 | — | |
BZQJNLXTYPFQDO
|
6.5 | IC50 | 8 | — | |
HNOFMPKORNQUAT
|
6.5 | IC50 | 8 | — | |
MWFGYPVIIVOLMX
|
6.5 | IC50 | 8 | — | |
ONIZUNGHVJHSTA
|
6.5 | IC50 | 8 | — | |
YYGHWHOJQMMELF
|
6.5 | IC50 | 8 | — | |
DMLMQDOHTGPLQS
|
6.5 | IC50 | 8 | — | |
IOBVXRYCNWSMKS
|
6.5 | IC50 | 8 | — | |
NZBPSKJJETVVOQ
|
6.5 | IC50 | 8 | — | |
DOTAHHROQNVDAF
|
6.5 | IC50 | 8 | — | |
HWBDCKWOZGYXRP
|
6.5 | IC50 | 8 | — | |
LMUCVOYUWPGAFT
|
6.5 | IC50 | 8 | — | |
OBQFGWRYNYWVEO
|
6.5 | IC50 | 8 | — | |
BORRMUVLRFHNSP
|
6.5 | IC50 | 8 | — | |
DJQCYLXTSKHWDY
|
6.5 | IC50 | 8 | — | |
HRJNMMQECAFPDZ
|
6.5 | IC50 | 8 | — | |
JIFVVFLJYNJCGH
|
6.5 | IC50 | 8 | — | |
NFHSJYKXENYICE
|
6.5 | IC50 | 8 | — | |
RWKVSRSWLBMQFZ
|
6.5 | IC50 | 8 | — | |
RGZQZTZWYUCVAY
|
6.5 | IC50 | 8 | — | |
UQOMRZMTEAAICA
|
6.5 | IC50 | 8 | — | |
ZZSPAALVTKNEPM
|
6.5 | IC50 | 8 | — | |
CYJSBMVDFDOPHN
|
6.4 | IC50 | 8 | — | |
DIHKSILZPYDOBE
|
6.4 | IC50 | 8 | — | |
DWTLVZKCLZPGBC
|
6.4 | IC50 | 8 | — | |
HUKWEGRPUKJFER
|
6.4 | IC50 | 8 | — | |
KGTAFFXGCXZNSF
|
6.4 | IC50 | 8 | — | |
MJFBXUGGKSQWGD
|
6.4 | IC50 | 8 | — | |
LMFDSWCIMMUPRR
|
6.4 | IC50 | 8 | — | |
VMLCDXGHZQRAON
|
6.4 | IC50 | 8 | — | |
SPSKNHQNGRNHNA
|
6.4 | IC50 | 8 | — | |
ULDRLGOGVDLJIJ
|
6.4 | IC50 | 8 | — | |
YYDHSDLMQPQAPK
|
6.4 | IC50 | 8 | — | |
BSRGPULLSTVXNM
|
6.4 | IC50 | 8 | — | |
SIMPDDFJFTVDMJ
|
6.4 | IC50 | 8 | — | |
ANCWBHOYWBANAV
|
6.4 | IC50 | 8 | — | |
NRULIRPKJVMPDY
|
6.4 | IC50 | 8 | — | |
OYICNAIIMAKSOI
|
6.4 | IC50 | 8 | — | |
GZDQTELBZTUJES
|
6.4 | IC50 | 8 | — | |
PFQDGQZERYZAPG
|
6.4 | IC50 | 8 | — | |
WCHIGRODWMUNBQ
|
6.4 | IC50 | 8 | — | |
HDMREEQKEGNABS
|
6.4 | IC50 | 8 | — | |
HKIUTFOLBFZVFL
|
6.4 | IC50 | 8 | — | |
KLXHRWVNBWIZHK
|
6.4 | IC50 | 8 | — |