Target Details
| UniProt AC | Q92569 |
|---|---|
| Gene Symbol | PIK3R3 |
| Protein Name | Phosphatidylinositol 3-kinase regulatory subunit gamma |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16454 (PI3K_P85_iSH2) PF00017 (SH2) |
Summary
- Multi-target molecules 289
- Clinical molecules 0
- Avg pChEMBL 6.75
KEGG Pathways (106)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Active Molecules (289)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
PEIFGMMJOLFHBE
|
7.4 | IC50 | 8 | — | |
WQCHPILKAPPVBW
|
7.4 | IC50 | 3 | — | |
GIQAVYAYXZICPG
|
7.4 | IC50 | 8 | — | |
YXFHSKVBWDUQIW
|
7.4 | IC50 | 8 | — | |
DZJGDNZVUPCXPX
|
7.4 | IC50 | 8 | — | |
HGAJTKWPNZDTRJ
|
7.3 | IC50 | 8 | — | |
NXHSCEQOULVBJS
|
7.3 | IC50 | 8 | — | |
UDDJJHILDQDTBM
|
7.3 | IC50 | 8 | — | |
AJRVMUXGCPDPOT
|
7.3 | IC50 | 8 | — | |
CQPIITBUFCLJQW
|
7.3 | IC50 | 8 | — | |
KXKADLQRHDFGBR
|
7.3 | IC50 | 8 | — | |
GXTWTBFETNXESR
|
7.3 | IC50 | 8 | — | |
OJCJBVKNUFOBRH
|
7.3 | IC50 | 8 | — | |
KBOCINOJPQBJHY
|
7.3 | IC50 | 8 | — | |
URZITQGEWBAINN
|
7.3 | IC50 | 8 | — | |
DFESDZGEOSBXMQ
|
7.2 | IC50 | 8 | — | |
SUGRZLGNJSNCRI
|
7.2 | IC50 | 8 | — | |
MEDRUYBTHOYYBE
|
7.2 | IC50 | 8 | — | |
MNSRURCAGZOZFY
|
7.2 | IC50 | 8 | — | |
GALWNKLIQPVNFO
|
7.2 | IC50 | 8 | — | |
IVJBBSRYSTWCRD
|
7.2 | IC50 | 8 | — | |
RABFNJUMQFEXTQ
|
7.2 | IC50 | 8 | — | |
UDGRXBYGXYOMBG
|
7.2 | IC50 | 8 | — | |
BXWUMOJSXVZWKL
|
7.1 | IC50 | 8 | — | |
FUMQATBGDGLOKH
|
7.1 | IC50 | 8 | — | |
JJIZJEXAZKGVCY
|
7.1 | IC50 | 8 | — | |
MKPRDFDJZIWWHV
|
7.1 | IC50 | 8 | — | |
VMHQTUFUBQDAPM
|
7.1 | IC50 | 8 | — | |
UDDJJHILDQDTBM
|
7.1 | IC50 | 8 | — | |
HWQXDWNWVAOPGP
|
7.1 | IC50 | 8 | — | |
YRTQNKZPRFQKJD
|
7.1 | IC50 | 8 | — | |
YZAOAYLROJTXKO
|
7.1 | IC50 | 8 | — | |
OSLYEXGCLGGXQD
|
7.1 | IC50 | 8 | — | |
RNJXEBWYBBNUDN
|
7.1 | IC50 | 8 | — | |
SNTINYRTBPIKSO
|
7.0 | IC50 | 8 | — | |
ALMGVNBNMXRCQV
|
7.0 | IC50 | 8 | — | |
BQXCOOOANMKMJT
|
7.0 | IC50 | 8 | — | |
GVSPTNBTTDSKBX
|
7.0 | IC50 | 8 | — | |
YYMJOSXPNZYXDU
|
7.0 | IC50 | 8 | — | |
QPTYEYDIOWOEAT
|
7.0 | IC50 | 8 | — | |
GALWNKLIQPVNFO
|
7.0 | IC50 | 8 | — | |
HWJADHWXPJWORQ
|
7.0 | IC50 | 8 | — | |
IXSNCCSCCZNQIN
|
7.0 | IC50 | 8 | — | |
LMUCVOYUWPGAFT
|
7.0 | IC50 | 8 | — | |
QBKNGTZPHDZTCI
|
7.0 | IC50 | 8 | — | |
XMLRYSWFMKXBFZ
|
7.0 | IC50 | 8 | — | |
YTYDCEPEGBYJIP
|
7.0 | IC50 | 8 | — | |
QBURVOCVNFVRQH
|
7.0 | IC50 | 8 | — | |
QGFAJQWXDUOVND
|
7.0 | IC50 | 8 | — | |
AYRHYIQWAHXGQS
|
6.9 | IC50 | 8 | — |