Target Details
| UniProt AC | Q16611 |
|---|---|
| Gene Symbol | BAK1 |
| Protein Name | Bcl-2 homologous antagonist/killer |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00452 (Bcl-2) |
Summary
- Multi-target molecules 6
- Clinical molecules 0
- Avg pChEMBL 6.79
KEGG Pathways (33)
- Apoptosis
- Apoptosis - multiple species
- Basal cell carcinoma
- Breast cancer
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- Epstein-Barr virus infection
- Gastric cancer
- Glioma
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Measles
- Melanoma
- MicroRNAs in cancer
- Non-small cell lung cancer
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Platinum drug resistance
- Protein processing in endoplasmic reticulum
- Salmonella infection
- Small cell lung cancer
- Thyroid cancer
- Transcriptional misregulation in cancer
- Viral carcinogenesis
Active Molecules (6)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HPLNQCPCUACXLM
|
7.6 | IC50 | 11 | — | |
RGQCMYHCMAKVGY
|
6.9 | Ki | 2 | — | |
QGJJPEJOSVXUMF
|
6.8 | Ki | 3 | — | |
VEPUCZUJLKAVNM
|
6.7 | Ki | 4 | — | |
VTTMIYITDPUEFZ
|
6.5 | Ki | 4 | — | |
HFBKSWPPVBSQLX
|
6.2 | Ki | 2 | — |