Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DROUGNYFAQIMFE
|
7.9 | IC50 | 4 | — | |
GDTQLZHHDRRBEB
|
7.9 | IC50 | 2 | — | |
HPLMNCNOXZFBBD
|
7.9 | Kd | 4 | — | |
HVLBTSWQHJSANX
|
7.9 | IC50 | 3 | Yes | |
JQVRXEMLYFQYRR
|
7.9 | IC50 | 3 | — | |
JVEOZYRULRDCNQ
|
7.9 | IC50 | 3 | — | |
LDXAGTHPWDVZFU
|
7.9 | IC50 | 3 | — | |
NUCRGYCYHSHHCH
|
7.9 | IC50 | 3 | — | |
OGQDHXGPFCDXGA
|
7.9 | IC50 | 4 | — | |
QKZKUCIKRGDWHQ
|
7.9 | IC50 | 3 | — | |
UXMOTLPQGDBXOT
|
7.9 | IC50 | 2 | — | |
YQSRHUJKRYNBHZ
|
7.9 | IC50 | 2 | — | |
ZGECDOGOLBHKSC
|
7.9 | IC50 | 3 | — | |
ZNGVEWWGDVLDRD
|
7.9 | IC50 | 2 | — | |
LUZARSGELRSGPD
|
7.9 | IC50 | 4 | — | |
FZBVNCFBCNXULH
|
7.9 | IC50 | 18 | — | |
RWKUOBJGDXCOKM
|
7.9 | IC50 | 2 | — | |
SALBEPPKTYADGM
|
7.9 | IC50 | 4 | — | |
FIWBNUYYYKCFHG
|
7.8 | IC50 | 4 | — | |
FNFFGFDJILZSOU
|
7.8 | IC50 | 2 | — | |
GFYZFDVAKCDQST
|
7.8 | IC50 | 5 | — | |
GZGYXKHNMJBZKD
|
7.8 | Kd | 4 | — | |
HZYVHWDHIRWTNY
|
7.8 | IC50 | 3 | — | |
IVBPBKLZQGEAEA
|
7.8 | Kd | 4 | — | |
OJQQCSPYLMDJQP
|
7.8 | IC50 | 3 | — | |
OPBZEBLTFIONGE
|
7.8 | Ki | 4 | — | |
QGEZMNVGCVUCMW
|
7.8 | IC50 | 2 | — | |
RCXVRYYLBZGIFP
|
7.8 | IC50 | 2 | Yes | |
RWTFBQBPISMKTK
|
7.8 | IC50 | 4 | — | |
WJTJZDOMFKCYEA
|
7.8 | IC50 | 6 | — | |
XTTRZMGIAJVRQG
|
7.8 | IC50 | 2 | — | |
ZDMNBFRGLJDTJG
|
7.8 | IC50 | 3 | — | |
MWUPDRLQBJKIBA
|
7.8 | IC50 | 4 | — | |
RRQTXZNIXFFWAR
|
7.8 | IC50 | 4 | — | |
APPAUNZXIPSWAS
|
7.8 | IC50 | 7 | Yes | |
FVONQZQMUHLATI
|
7.8 | IC50 | 3 | — | |
GUMCACBOTLWYCR
|
7.8 | IC50 | 2 | — | |
HNOVOESCCUJDRT
|
7.8 | Ki | 2 | — | |
IQOTVGHBBHOBKR
|
7.8 | IC50 | 2 | — | |
JOUFMDMLXUIBIV
|
7.8 | IC50 | 4 | — | |
LGACHOLIGNCDSQ
|
7.8 | IC50 | 4 | — | |
MCPXUGGNYXHTMJ
|
7.8 | IC50 | 2 | — | |
RJHSFROTHLVFBY
|
7.8 | Ki | 4 | — | |
SMNFESRDGJONQB
|
7.8 | IC50 | 2 | — | |
WDTQXFIPOWRSCO
|
7.8 | IC50 | 2 | — | |
YJNZNIAEANFDMJ
|
7.8 | IC50 | 2 | — | |
ZRLPBAZNQXQPRP
|
7.8 | IC50 | 2 | — | |
YTBQDRNYIQRKTK
|
7.8 | IC50 | 2 | — | |
AZFUYVNWRUXRLD
|
7.8 | IC50 | 2 | — | |
BQXDLQUNDYMBSC
|
7.8 | Ki | 4 | — |