Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
URPHWXWGWHZRLT
|
8.0 | IC50 | 3 | — | |
VFRGUPCPOYDATL
|
8.0 | IC50 | 3 | — | |
YYLIDCHASSSNQK
|
8.0 | IC50 | 4 | — | |
RNKGUQCZUZXJAW
|
8.0 | IC50 | 2 | — | |
JQZGDZPOTURSKE
|
8.0 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
8.0 | IC50 | 408 | — | |
CTLVZTMBHKZFIR
|
8.0 | IC50 | 3 | — | |
HIVGXEUXJUXVAR
|
8.0 | IC50 | 2 | — | |
HOBGSWDBYMRRJR
|
8.0 | IC50 | 4 | — | |
KADSTJJZALTROR
|
8.0 | IC50 | 4 | — | |
MMEJLCRBNBQORJ
|
8.0 | IC50 | 3 | — | |
OHMPXDCOVKOOAN
|
8.0 | IC50 | 4 | — | |
PNRBQMZDBPEICZ
|
8.0 | IC50 | 3 | — | |
QFXFIEVXAUEHEV
|
8.0 | IC50 | 6 | — | |
SUXULCDTOIYHQM
|
8.0 | IC50 | 5 | — | |
TZPMPKKHGISYQB
|
8.0 | IC50 | 2 | — | |
URQAXVPGUSETSW
|
8.0 | IC50 | 4 | — | |
VAGUQCZJQQNYIR
|
8.0 | Ki | 3 | — | |
WDCXQMIUZVKFEE
|
8.0 | IC50 | 2 | — | |
WWSBAAXRYHTMOX
|
8.0 | IC50 | 2 | — | |
XLYVQVWMTOLDNL
|
8.0 | IC50 | 21 | — | |
XLYVQVWMTOLDNL
|
8.0 | IC50 | 21 | — | |
YTGWXEIUYWQLJS
|
8.0 | IC50 | 4 | — | |
DSKSACIENVKOMV
|
8.0 | IC50 | 2 | — | |
GSCVYTUEFYPEHY
|
8.0 | IC50 | 2 | — | |
PXHGZEDOCKTIJR
|
8.0 | IC50 | 2 | — | |
ZJHPTJJPYYJHCT
|
7.9 | IC50 | 2 | — | |
AUCMAJMDOAHHEL
|
7.9 | IC50 | 4 | — | |
AVUUHIYJPTWYNX
|
7.9 | IC50 | 9 | — | |
DREMCOHKCICYCA
|
7.9 | Kd | 4 | — | |
FCJMQXODPHVAOG
|
7.9 | IC50 | 4 | — | |
HIFGZZBMONHQCC
|
7.9 | IC50 | 2 | — | |
HJWMLCDGRWWLAQ
|
7.9 | Kd | 3 | — | |
HTUPONJUVMCVCW
|
7.9 | IC50 | 6 | Yes | |
JPYOIFOGVHGGQA
|
7.9 | IC50 | 4 | — | |
MGVWPOMQHQAMAV
|
7.9 | IC50 | 3 | — | |
OLBVWPWMKHAGFN
|
7.9 | IC50 | 2 | — | |
PEDMIJDFAWDUDE
|
7.9 | IC50 | 3 | — | |
PQRNFUISVXRWPF
|
7.9 | IC50 | 2 | — | |
STYBOAPFAFDXGS
|
7.9 | IC50 | 3 | — | |
UURQEFJLVUODIL
|
7.9 | IC50 | 4 | — | |
VXMFHVFTECVHPF
|
7.9 | IC50 | 4 | — | |
XOGIWVYJWYLFOL
|
7.9 | IC50 | 2 | — | |
XVVANFOECICSLK
|
7.9 | IC50 | 4 | — | |
XZCLCFIAUCVNJF
|
7.9 | IC50 | 4 | — | |
BOPSUAHGQHFKGG
|
7.9 | Ki | 3 | — | |
RNOZPQYHYKQEEX
|
7.9 | IC50 | 4 | — | |
NSQSYDVAHJDFHK
|
7.9 | IC50 | 2 | — | |
WMMDAHPQCCGGSP
|
7.9 | IC50 | 2 | — | |
AGUJKUAFJPEJNC
|
7.9 | IC50 | 2 | — |