Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NOJPAMWBIRLVJT
|
8.1 | IC50 | 2 | — | |
URNGXAVMGITILR
|
8.1 | IC50 | 4 | — | |
XIWRCSVXKPGGAJ
|
8.1 | Kd | 4 | — | |
YRJCGFIHLVCSEO
|
8.1 | IC50 | 2 | — | |
IBHXVVYFEIGWLJ
|
8.1 | IC50 | 4 | — | |
QIBLVZMAUUVSMB
|
8.1 | IC50 | 4 | — | |
SMDNOKALZQOTCU
|
8.1 | IC50 | 4 | — | |
YYJPOMCMGUTTHB
|
8.1 | IC50 | 2 | — | |
PNNHSDGMXFKVRN
|
8.1 | IC50 | 2 | — | |
QICPQLFMWYQJGX
|
8.1 | IC50 | 5 | — | |
USUSRWRXNKNUGL
|
8.1 | IC50 | 3 | — | |
WPHLFVIDUSHWHQ
|
8.1 | IC50 | 3 | Yes | |
ZIFZTQMNCSFVKL
|
8.1 | IC50 | 2 | — | |
AAIWZQZMQJIDII
|
8.1 | IC50 | 4 | — | |
AUNDYKNGIPQOPL
|
8.1 | IC50 | 2 | — | |
BDDQTHYDKKYXON
|
8.1 | IC50 | 3 | — | |
BDGXAHBOBRAVIN
|
8.1 | IC50 | 3 | — | |
DGUSFVFTIHATAT
|
8.1 | IC50 | 5 | Yes | |
DJIQDCXVLBGSFJ
|
8.1 | IC50 | 4 | — | |
FDVXDXGMVYUYFV
|
8.1 | IC50 | 4 | — | |
JCSZOMMQIMMAMS
|
8.1 | IC50 | 4 | — | |
LFTXLPYHWCSFSL
|
8.1 | IC50 | 2 | — | |
NAAVOCGXGLOQSN
|
8.1 | IC50 | 2 | — | |
NSOPDMYYXBLFIE
|
8.1 | IC50 | 3 | — | |
QGJNGXXVCVFADC
|
8.1 | IC50 | 2 | — | |
QHNXZMWGDCUUFW
|
8.1 | IC50 | 2 | — | |
VBECRVQGKLDJIE
|
8.1 | IC50 | 2 | — | |
ZMELOYOKMZBMRB
|
8.1 | IC50 | 4 | — | |
ZMELOYOKMZBMRB
|
8.1 | IC50 | 4 | — | |
MZRCCMMKNFJJEA
|
8.0 | IC50 | 4 | — | |
CBDNDJPIMQLOAF
|
8.0 | IC50 | 2 | — | |
YARHUYMJLJCURZ
|
8.0 | IC50 | 3 | — | |
YBJHGWIVFMBWOO
|
8.0 | IC50 | 4 | — | |
MTZANZYELGIMJM
|
8.0 | IC50 | 2 | — | |
RNPHICWBCUQEML
|
8.0 | IC50 | 4 | — | |
ZHYRMYNGJZLEKN
|
8.0 | IC50 | 4 | — | |
ZJQYVSTVRXOFQL
|
8.0 | IC50 | 4 | — | |
AALWZYBTBKNLKF
|
8.0 | IC50 | 4 | — | |
AQXKGSIGOIIUJI
|
8.0 | IC50 | 4 | — | |
BGPSGELIEAWXPK
|
8.0 | IC50 | 4 | — | |
BMNBPNRAKNFVAB
|
8.0 | IC50 | 4 | — | |
CLESKVZBGDCDJJ
|
8.0 | IC50 | 3 | — | |
DGJNSNHNZJVEFO
|
8.0 | IC50 | 3 | — | |
FSRFRWLXYSIGBM
|
8.0 | IC50 | 4 | — | |
KNXQEJUJQOZAKP
|
8.0 | IC50 | 7 | Yes | |
LQYPBKQMDVWUGO
|
8.0 | Kd | 2 | — | |
MSXZXFPYTVQJIL
|
8.0 | IC50 | 4 | — | |
RETBYBLRWLXQHI
|
8.0 | IC50 | 2 | — | |
SDWCOPUSJBCAAX
|
8.0 | IC50 | 4 | — | |
SGZKENSKCPVZBM
|
8.0 | IC50 | 2 | — |