Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QGDUHRXRHUCXIQ
|
8.2 | IC50 | 3 | — | |
RTEPGYYCYOJXTD
|
8.2 | IC50 | 4 | — | |
UGOQPKUREUTQEZ
|
8.2 | IC50 | 4 | — | |
UYMYCUSVHPBJBL
|
8.2 | IC50 | 4 | — | |
XTXBDMYKIBMUHQ
|
8.2 | IC50 | 2 | — | |
YEIASMOUYNOXGA
|
8.2 | IC50 | 5 | — | |
NWGBRDDTFZTOOA
|
8.2 | IC50 | 2 | — | |
FQYJTHIYAQQJAB
|
8.2 | IC50 | 4 | — | |
QLURYKVIFSRCNJ
|
8.2 | IC50 | 4 | — | |
MPFNOCFGLHYSEQ
|
8.2 | IC50 | 2 | — | |
TWPJJJZCYVFUOA
|
8.2 | IC50 | 3 | — | |
UZNTWHBHIHKRLK
|
8.2 | IC50 | 2 | — | |
XEQBKWGVMSNLAI
|
8.2 | IC50 | 4 | — | |
ADQZGIYHFQQPRB
|
8.2 | IC50 | 10 | — | |
ALNFKLJYTICTCF
|
8.2 | IC50 | 4 | — | |
BNOAPQWBXKBDLM
|
8.2 | IC50 | 2 | — | |
BZPKVUCAGBEWOQ
|
8.2 | IC50 | 3 | — | |
DHVBTKDVRAXVKY
|
8.2 | IC50 | 3 | — | |
FJCORFQIRVXPCY
|
8.2 | IC50 | 4 | — | |
QAKIGHBHPHZCJC
|
8.2 | IC50 | 4 | — | |
RASCHEQRJMEENP
|
8.2 | IC50 | 4 | — | |
RKNYQDPVAHZMFZ
|
8.2 | IC50 | 3 | — | |
RULGKKPHDCFAJF
|
8.2 | IC50 | 4 | — | |
SOTOGKXMOXJSOQ
|
8.2 | IC50 | 2 | — | |
UUDAKQZBMTXFJA
|
8.2 | IC50 | 4 | — | |
WHKSAKSSQHTIKP
|
8.2 | IC50 | 4 | — | |
WWTTXMQTJXMGQM
|
8.2 | IC50 | 4 | — | |
XETRNBBNUVDOJG
|
8.2 | IC50 | 2 | — | |
YGZNOUTVUALXEX
|
8.2 | IC50 | 3 | — | |
YMXZIONZPMRKQD
|
8.2 | IC50 | 5 | — | |
ZBZUZJQNKUWJSS
|
8.2 | IC50 | 4 | — | |
ZQXGAYYYCBUPSG
|
8.2 | IC50 | 2 | — | |
HRQLIPAWEHEJGG
|
8.1 | IC50 | 4 | — | |
ZLBVVUMOZWDVAU
|
8.1 | IC50 | 4 | — | |
VXRUZPWNIPZAQV
|
8.1 | IC50 | 2 | — | |
WIIMYXRFJKRBLA
|
8.1 | IC50 | 4 | — | |
JEBBTQWFFYQVCM
|
8.1 | IC50 | 4 | — | |
GWAMNECAZIXYSS
|
8.1 | IC50 | 4 | — | |
ILNRGJOBWHKROC
|
8.1 | IC50 | 4 | — | |
CLRSATALQPIPQY
|
8.1 | IC50 | 3 | — | |
CTSZZXNCNLCFRF
|
8.1 | IC50 | 2 | — | |
HUIYFTUPVRGRGO
|
8.1 | Kd | 4 | — | |
IEIWIPIQYLVOCL
|
8.1 | IC50 | 3 | — | |
ITENSOATZCMKDD
|
8.1 | IC50 | 3 | — | |
JEHBCDCKKVKVGB
|
8.1 | IC50 | 3 | — | |
JSEJMGKNQGRPEI
|
8.1 | IC50 | 3 | — | |
KSCQZBDAQWTHKN
|
8.1 | IC50 | 4 | — | |
LHYKFLNJIXCRLM
|
8.1 | IC50 | 4 | — | |
MVCOAUNKQVWQHZ
|
8.1 | IC50 | 54 | Yes | |
NKJNHXKAASJVEM
|
8.1 | IC50 | 3 | — |