Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JWZSSEWMVYKYKW
|
8.4 | IC50 | 3 | — | |
RYMVWMWRYADLJC
|
8.4 | IC50 | 4 | — | |
VKTAENBLRPMXKK
|
8.4 | IC50 | 3 | Yes | |
JYYLVUFNAHSSFE
|
8.4 | IC50 | 9 | — | |
QEXCGBIQJWBHDU
|
8.4 | IC50 | 3 | — | |
SXEUNZBMEKAEKG
|
8.4 | IC50 | 2 | — | |
CGTKKBWMFVAOFJ
|
8.4 | IC50 | 4 | — | |
SAVNTIGFSBRMSL
|
8.3 | IC50 | 3 | — | |
QBRGSYLNUUOUBB
|
8.3 | IC50 | 2 | — | |
BHSHXBRDUHHNCK
|
8.3 | IC50 | 2 | — | |
BBDYTNGLQLQTOV
|
8.3 | IC50 | 4 | — | |
CGXCGLMVTWFROO
|
8.3 | IC50 | 4 | — | |
CJXUHPRULWSPBE
|
8.3 | IC50 | 7 | — | |
DTYGFXKVLYKJLW
|
8.3 | IC50 | 3 | — | |
FYISVERUOWLPAV
|
8.3 | IC50 | 2 | — | |
GBEBCBVAFSGAEO
|
8.3 | IC50 | 2 | — | |
HTFVITLDAZUSJX
|
8.3 | IC50 | 4 | — | |
HXMGCTFLLWPVFM
|
8.3 | IC50 | 6 | — | |
HXNUFFCHRIWTRZ
|
8.3 | IC50 | 5 | — | |
IFLRTIBATNZOEH
|
8.3 | IC50 | 4 | — | |
IHCLBOWQUVPHBB
|
8.3 | IC50 | 3 | — | |
JMJNNWUSBNQXNX
|
8.3 | IC50 | 2 | — | |
KUGYCLJHAOPSBD
|
8.3 | Kd | 4 | — | |
MMJHUKOMQZXIPW
|
8.3 | IC50 | 3 | — | |
OJKGJLKJOICLKA
|
8.3 | IC50 | 4 | — | |
PDQILYUWWBSUJV
|
8.3 | IC50 | 4 | — | |
PFOOSTYYGDXTKA
|
8.3 | IC50 | 4 | — | |
QGFOJZMDPXDGSA
|
8.3 | IC50 | 3 | — | |
QUABQYHYBYAXDR
|
8.3 | IC50 | 2 | — | |
RTDCVLCTBQDLBW
|
8.3 | IC50 | 4 | — | |
SXEJPJAKKSSHHC
|
8.3 | IC50 | 4 | — | |
UDVSRXQVDHWZAL
|
8.3 | IC50 | 4 | — | |
UYFZFNBZWUNCQS
|
8.3 | IC50 | 4 | — | |
WTRQXHALVSEXHZ
|
8.3 | IC50 | 3 | — | |
YEAPWTJFLNSZPB
|
8.3 | IC50 | 2 | — | |
IADKHNLYTDEPGD
|
8.3 | IC50 | 6 | — | |
WKKRGQXAOQBWDF
|
8.3 | IC50 | 2 | — | |
YCHQFRFMSZAMGH
|
8.3 | IC50 | 2 | — | |
IFPPYSWJNWHOLQ
|
8.2 | Kd | 52 | Yes | |
ATSRNUWJDQUCNU
|
8.2 | IC50 | 3 | — | |
BOQNSWFZUHQNRG
|
8.2 | IC50 | 5 | — | |
BPJALVMFXXJAJS
|
8.2 | IC50 | 3 | — | |
FGBHWWCXGQAKAZ
|
8.2 | IC50 | 4 | — | |
FOKDTUHZKJGPII
|
8.2 | IC50 | 2 | — | |
FZGSPFYSRVCSSA
|
8.2 | IC50 | 2 | — | |
GRFBNEAPKLWFPA
|
8.2 | IC50 | 4 | — | |
ICRKLHQKHODTLD
|
8.2 | IC50 | 4 | — | |
KLCRZBNGDBKHFA
|
8.2 | IC50 | 4 | — | |
MIAZWLXBNITBFW
|
8.2 | IC50 | 4 | — | |
PJUSCKOQLSMBPU
|
8.2 | IC50 | 2 | — |