Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NCFXYYJGQFCMMG
|
8.5 | IC50 | 4 | — | |
NIQVLUYKQSAUSE
|
8.5 | IC50 | 2 | — | |
NPHRPHMHAOPRTH
|
8.5 | IC50 | 2 | — | |
OSYGDWRURYLVIZ
|
8.5 | IC50 | 2 | — | |
RSCUAYDLLDUTKX
|
8.5 | IC50 | 4 | — | |
SMWGCUOXWXYZPF
|
8.5 | IC50 | 5 | — | |
WCTNEALHPXRJMI
|
8.5 | IC50 | 3 | — | |
WQKREPZMMAPYRS
|
8.5 | IC50 | 4 | — | |
YCWQIUKZOZXDEM
|
8.5 | IC50 | 3 | — | |
ZVXGJXOOHDCIBO
|
8.5 | Kd | 4 | — | |
KIJQUBGKXJVPER
|
8.5 | IC50 | 4 | — | |
ZZTMFGIGOADCFX
|
8.5 | IC50 | 2 | — | |
DQXZQCNGYTVWJL
|
8.5 | IC50 | 4 | — | |
WIRUYYYAAJOIKO
|
8.5 | Ki | 4 | — | |
OWHSAASMRWOHHO
|
8.5 | IC50 | 3 | Yes | |
SWEOMWCGPLXIKR
|
8.5 | IC50 | 3 | — | |
KGUYOFKQHDMARG
|
8.5 | IC50 | 4 | — | |
OYOUIHFZUAKCEF
|
8.5 | IC50 | 4 | — | |
CCELPATZKCADOK
|
8.4 | IC50 | 4 | — | |
FOUXDDCORYJSOF
|
8.4 | IC50 | 2 | — | |
FYSRKRZDBHOFAY
|
8.4 | Kd | 8 | — | |
WMTFXHFSJAESMU
|
8.4 | IC50 | 3 | Yes | |
QGJDHDIEZQDSIA
|
8.4 | IC50 | 2 | — | |
AFFDEZDCXSAKBU
|
8.4 | IC50 | 4 | — | |
AKUFVJURRNGOQZ
|
8.4 | IC50 | 3 | — | |
ANZAPACAXUOLFY
|
8.4 | Kd | 4 | — | |
BEBZPLUXTCGKDB
|
8.4 | IC50 | 3 | — | |
CQPNJQRTSADQCI
|
8.4 | IC50 | 2 | — | |
CWEBLBDEUUBLRL
|
8.4 | IC50 | 4 | — | |
FOBRPXRJBHDKKT
|
8.4 | IC50 | 2 | — | |
GDQIFSOQZTZXJK
|
8.4 | IC50 | 2 | — | |
HNWUVGPTWJORJZ
|
8.4 | IC50 | 2 | — | |
JTERLHICJVJIRK
|
8.4 | IC50 | 3 | — | |
JXKHBWPSMRRQQD
|
8.4 | IC50 | 2 | — | |
KQWCGDXCRBTZJV
|
8.4 | IC50 | 4 | — | |
LNMRSSIMGCDUTP
|
8.4 | IC50 | 13 | — | |
OCGMYHIDTHTZSV
|
8.4 | IC50 | 4 | — | |
OJLWRWYDIQGJIK
|
8.4 | IC50 | 2 | — | |
SDCMBIATJHKWGV
|
8.4 | IC50 | 2 | — | |
SSIFHFIRVJXKOP
|
8.4 | IC50 | 4 | — | |
UQFRSHRWRKYNDE
|
8.4 | IC50 | 17 | Yes | |
VUBCLLUPUOLGKY
|
8.4 | IC50 | 4 | — | |
WLXUDQMWNQFZOR
|
8.4 | IC50 | 2 | — | |
XAQAXLLEJACTLM
|
8.4 | IC50 | 4 | — | |
YEXAEGWRSZOFGW
|
8.4 | IC50 | 4 | — | |
ZBXKCENUEFHXCB
|
8.4 | IC50 | 2 | — | |
ZZZJRULMCGMYRH
|
8.4 | IC50 | 4 | — | |
ILYNRQUIMSWFFI
|
8.4 | IC50 | 2 | — | |
KVSYGXJLPJDFLW
|
8.4 | IC50 | 2 | — | |
PNYSWMQVUBFTDP
|
8.4 | IC50 | 4 | — |