Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
GSUDSWBWGLGBGN
|
8.7 | IC50 | 3 | — | |
HLKIWJNLTMGQET
|
8.7 | IC50 | 2 | — | |
HYEOMJSVLMONGY
|
8.7 | IC50 | 4 | — | |
IOCRDUAOXZXTFV
|
8.7 | IC50 | 4 | — | |
IXWAAWQRRFJLQU
|
8.7 | IC50 | 3 | — | |
IYRPCWRKUVTLQK
|
8.7 | IC50 | 2 | — | |
IZZSAERQBCCMSM
|
8.7 | IC50 | 4 | — | |
KADWMAJVBHJWDX
|
8.7 | IC50 | 3 | — | |
KIPZYDCBLYBUMY
|
8.7 | IC50 | 4 | — | |
KKBSRZBNVASLTJ
|
8.7 | IC50 | 3 | — | |
LHVMOVISOAUTPX
|
8.7 | IC50 | 4 | — | |
LQXUFIFTFVOCHC
|
8.7 | IC50 | 2 | — | |
QEVXPGAJPJCDLY
|
8.7 | IC50 | 2 | — | |
UBWALTPIDHCQBF
|
8.7 | IC50 | 3 | — | |
UVBXNSDEQMCSMK
|
8.7 | IC50 | 2 | — | |
WIGNNIARPGHXFO
|
8.7 | IC50 | 4 | — | |
WOTWLRUBONIHLC
|
8.7 | IC50 | 2 | — | |
WQOAQFRQXWKXRO
|
8.7 | IC50 | 2 | — | |
XJBQSGXAJXTXAC
|
8.7 | IC50 | 5 | — | |
XXCAPLNLONGIPM
|
8.7 | IC50 | 4 | — | |
YWBUMBUFDDSLCR
|
8.7 | IC50 | 4 | — | |
ZLQKJFNLHHGAQF
|
8.7 | IC50 | 5 | — | |
ZOBKJVAECISXJA
|
8.7 | IC50 | 2 | — | |
PTPMBQNCXYRTGN
|
8.7 | IC50 | 4 | — | |
QIZRYGQQBSMXJB
|
8.7 | IC50 | 2 | — | |
VOIHJDKJPGOZPU
|
8.7 | IC50 | 4 | — | |
KFEQXUZWOONGQK
|
8.6 | IC50 | 4 | — | |
YJAHLZMTOSJPLA
|
8.6 | IC50 | 2 | — | |
DVEYHFXOGUYFBU
|
8.6 | IC50 | 5 | — | |
GXRLJHPCFBRKQO
|
8.6 | IC50 | 4 | — | |
JKKUMOHJMCYPCS
|
8.6 | IC50 | 2 | — | |
MDEAKINSCUXXNF
|
8.6 | Ki | 4 | — | |
SXZUMVUZVHQTFR
|
8.6 | IC50 | 2 | — | |
UOTOSGLKBCSIBU
|
8.6 | IC50 | 2 | — | |
WTYSITXLWIBADH
|
8.6 | IC50 | 4 | — | |
YAWZIQKDHQIHOS
|
8.6 | IC50 | 2 | — | |
UTVABCSMEKUFLJ
|
8.6 | IC50 | 7 | Yes | |
CSZIDFIPZUUMDG
|
8.6 | IC50 | 3 | — | |
MMOVYTMEVBLPLX
|
8.6 | IC50 | 4 | — | |
CUNDIGFRTACXCX
|
8.6 | IC50 | 4 | — | |
FMPGVEXFSHPKCI
|
8.6 | IC50 | 2 | — | |
JPAXUPOTRXLXQE
|
8.6 | IC50 | 4 | — | |
KCAJXIDMCNPGHZ
|
8.5 | IC50 | 3 | — | |
DAXMIVDYBBFSGN
|
8.5 | IC50 | 4 | — | |
DPSYCGMSLWKDDR
|
8.5 | Kd | 4 | — | |
DVRSTRMZTAPMKO
|
8.5 | IC50 | 10 | Yes | |
GWOFQUMBWYKHFL
|
8.5 | IC50 | 5 | — | |
HFDJAPMETZJFMI
|
8.5 | IC50 | 2 | — | |
HJDQNNIRKWGQGL
|
8.5 | IC50 | 4 | — | |
JSOCRZCXAZAHPO
|
8.5 | IC50 | 2 | — |