Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JIFZZVZROIFPKB
|
9.0 | IC50 | 5 | — | |
MKHGLLWUWDYQIR
|
9.0 | IC50 | 2 | — | |
OBALKFHHXFROHH
|
9.0 | IC50 | 3 | — | |
RHSMFYIHIIADSH
|
9.0 | Kd | 5 | — | |
RNGNGIHVGNTTHO
|
9.0 | IC50 | 3 | — | |
SLDNXLAQRVJNJO
|
9.0 | IC50 | 5 | Yes | |
XANMCBRIKIVXBI
|
9.0 | IC50 | 2 | — | |
XGOUHJLISKQBDN
|
9.0 | IC50 | 4 | — | |
YKPZOVVLNSAWPV
|
9.0 | IC50 | 2 | — | |
YELORNJOYXXAFO
|
9.0 | IC50 | 4 | — | |
RCOGIBMVENMBNJ
|
9.0 | Kd | 3 | — | |
SBVVPLRDGQGTMO
|
9.0 | Ki | 2 | — | |
OZELIFLDRWQKKG
|
8.9 | IC50 | 2 | — | |
FIUUNLIXVYHRAD
|
8.9 | IC50 | 2 | — | |
SAZVRXTVWZAHBI
|
8.9 | IC50 | 4 | — | |
KCXCFBQZWGUDQC
|
8.9 | IC50 | 4 | — | |
WMXJYEDCJIDCNY
|
8.9 | IC50 | 2 | — | |
BTFCCPKDGZFGPR
|
8.8 | IC50 | 3 | — | |
KKKRKRMVJRHDMG
|
8.8 | IC50 | 14 | — | |
MEMWBKJNZJSCOG
|
8.8 | IC50 | 4 | — | |
ZWVCUFJZBBAOFI
|
8.8 | IC50 | 2 | — | |
MNEXDVSJIUQQRH
|
8.8 | IC50 | 6 | — | |
MFKZRXRMXDEYFP
|
8.8 | IC50 | 4 | — | |
GGUFDSKGQOZGOY
|
8.8 | IC50 | 4 | — | |
LEQIYANLBCTNDM
|
8.8 | IC50 | 4 | — | |
VPYHMFOFGLWNPN
|
8.8 | IC50 | 2 | — | |
ZXKCKRXMZFAGCD
|
8.8 | Ki | 4 | — | |
TWWUNSJOKCOGKZ
|
8.8 | IC50 | 4 | — | |
BSKASJBDVDOKBE
|
8.8 | IC50 | 4 | — | |
DDDPTRGZLJPPQR
|
8.8 | Ki | 6 | — | |
FIUUNLIXVYHRAD
|
8.8 | IC50 | 2 | — | |
HWKBOBDBGONATL
|
8.8 | IC50 | 2 | — | |
JLIDQWKTZPUAMJ
|
8.8 | Ki | 4 | — | |
UBUNMXDLLOPUIM
|
8.8 | IC50 | 2 | — | |
WIBSCIIGFIRSRV
|
8.8 | IC50 | 2 | — | |
BKDNDBILDOURLT
|
8.8 | IC50 | 2 | — | |
OBHNTFJGFUEQCQ
|
8.8 | Ki | 2 | — | |
YQMXHHPOKLHLOD
|
8.8 | IC50 | 2 | — | |
GDCTXLFXTKDKOE
|
8.7 | Ki | 4 | — | |
GZGRGXPFYDFNHF
|
8.7 | Ki | 3 | — | |
INZKYFAYQUYDOC
|
8.7 | Kd | 3 | — | |
MBAYOYOHXJVBHG
|
8.7 | IC50 | 4 | — | |
SZRCCCNFNLAWGP
|
8.7 | IC50 | 4 | — | |
AKHMXEIJWVZWHP
|
8.7 | IC50 | 4 | — | |
CEZSPTXMXOJSRJ
|
8.7 | IC50 | 5 | — | |
CSVXUAKTJJDCMS
|
8.7 | IC50 | 6 | — | |
DQLUUNQMRQJPAL
|
8.7 | IC50 | 3 | — | |
FEFIXEMJIYHFAZ
|
8.7 | IC50 | 4 | — | |
FPSYUXXLCHMFRU
|
8.7 | IC50 | 4 | — | |
FRMOMXCMQJRNOS
|
8.7 | Kd | 4 | — |