Target Details
| UniProt AC | Q16539 |
|---|---|
| Gene Symbol | MAPK14 |
| Protein Name | Mitogen-activated protein kinase 14 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 1,754
- Clinical molecules 97
- Avg pChEMBL 7.28
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (1,754)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VGEXRDWWPSGZDH
|
12.0 | Kd | 4 | — | |
XJGYVASDBIPRAF
|
10.3 | Ki | 4 | — | |
MXMWXOMNFWLHHQ
|
10.3 | Ki | 4 | — | |
NEOFBONIFALDKM
|
10.3 | IC50 | 3 | — | |
WAKUIUNRDNSMQR
|
10.3 | Kd | 4 | — | |
UONISFJXHMSTQN
|
10.2 | Ki | 4 | — | |
VXWYKMMJKQFNRP
|
10.2 | Ki | 4 | — | |
XCTKFTOEAKJMII
|
10.1 | IC50 | 2 | — | |
IDTKLCNLVPKYPA
|
10.0 | Kd | 4 | — | |
PPZSTJQLZOPKBO
|
10.0 | IC50 | 3 | — | |
WYBGYJNIKOAPQI
|
9.9 | Ki | 4 | — | |
TVPNMNQKHNYGNA
|
9.8 | Ki | 4 | — | |
ZXONHXQWZPBOLO
|
9.8 | IC50 | 4 | Yes | |
NVOVOGZPCHXJBQ
|
9.8 | Ki | 4 | — | |
GYCYTYZLLQPEBT
|
9.7 | IC50 | 4 | — | |
PDQRLXXNHRRHKI
|
9.7 | IC50 | 3 | — | |
SKSUDAWXICVVEY
|
9.7 | IC50 | 2 | — | |
VMOVZKURWYNTLN
|
9.7 | Ki | 7 | — | |
RQVKVJIRFKVPBF
|
9.6 | Ki | 13 | — | |
FNZGHWSBOGBXEO
|
9.5 | IC50 | 3 | — | |
JUCVIQPUESHERW
|
9.5 | IC50 | 4 | — | |
RXQPWAXTLUQACC
|
9.4 | Ki | 3 | — | |
QWHMQQHHLRCLLD
|
9.4 | Ki | 4 | — | |
DYVTYPINLOPJMV
|
9.4 | Ki | 4 | — | |
KYTWYELKTBDZFP
|
9.3 | IC50 | 4 | — | |
OVKIYZXGCCAIJG
|
9.3 | Ki | 6 | — | |
XXAWRUNZQCOIKO
|
9.3 | IC50 | 4 | — | |
IHBPAWYBWDVDJK
|
9.3 | IC50 | 4 | — | |
DKHCMNUPWHVUKS
|
9.2 | IC50 | 2 | — | |
GUJHNVVLTAXWRX
|
9.2 | IC50 | 4 | — | |
KFEQXUZWOONGQK
|
9.2 | IC50 | 4 | — | |
KXNNHYBPDFMKQK
|
9.2 | IC50 | 4 | — | |
PRMZAUJLQXIACS
|
9.2 | IC50 | 2 | — | |
DEVGLXQREUCUSP
|
9.2 | Ki | 4 | — | |
PTPMBQNCXYRTGN
|
9.2 | IC50 | 5 | — | |
QICPQLFMWYQJGX
|
9.2 | IC50 | 5 | — | |
RVTPPRYTUBCENU
|
9.2 | IC50 | 4 | — | |
TZOYXRMEFDYWDQ
|
9.1 | IC50 | 4 | — | |
DMTJDVSGJMJVRQ
|
9.1 | Ki | 2 | — | |
FDNUPMASTHASFG
|
9.1 | IC50 | 2 | — | |
XANMCBRIKIVXBI
|
9.1 | IC50 | 2 | — | |
XBYXPZQYVBMFAI
|
9.1 | IC50 | 2 | — | |
WLMGLORLNFEUDG
|
9.1 | IC50 | 4 | — | |
XQRUWZMHPKNIDA
|
9.1 | Kd | 2 | — | |
FNYWVPCDXNSWSG
|
9.1 | IC50 | 4 | — | |
JGSOKYHCMXFSQG
|
9.0 | IC50 | 4 | — | |
HSQMAKZHOAZZPL
|
9.0 | Ki | 4 | — | |
DYFJXOPTRKATQT
|
9.0 | IC50 | 2 | — | |
GWCMRHRHTWMOLO
|
9.0 | IC50 | 4 | — | |
HOHLGEPKIHZUGO
|
9.0 | IC50 | 2 | — |