Target Details
| UniProt AC | Q15796 |
|---|---|
| Gene Symbol | SMAD2 |
| Protein Name | SMAD family member 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF03165 (MH1) PF03166 (MH2) |
Summary
- Multi-target molecules 10
- Clinical molecules 0
- Avg pChEMBL 7.03
KEGG Pathways (20)
- AGE-RAGE signaling pathway in diabetic complications
- Apelin signaling pathway
- Cell cycle
- Cellular senescence
- Chagas disease
- Colorectal cancer
- Diabetic cardiomyopathy
- Endocytosis
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T-cell leukemia virus 1 infection
- Inflammatory bowel disease
- Pancreatic cancer
- Pathways in cancer
- Proteoglycans in cancer
- Relaxin signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- TGF-beta signaling pathway
- Th17 cell differentiation
Associated Diseases (3)
Active Molecules (10)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SJMLJWOLGMOTLG
|
7.5 | IC50 | 3 | — | |
MWKSRKSEWLRPBL
|
7.5 | Kd | 1075 | — | |
ONEKFAPECJXSTI
|
7.2 | IC50 | 3 | — | |
ONEKFAPECJXSTI
|
7.2 | IC50 | 3 | — | |
SQFBFKKGAWCQAU
|
7.0 | IC50 | 3 | — | |
ONEKFAPECJXSTI
|
7.0 | IC50 | 3 | — | |
CKSXTSLBLCBNFG
|
6.9 | IC50 | 3 | — | |
ONEKFAPECJXSTI
|
6.8 | IC50 | 3 | — | |
ONEKFAPECJXSTI
|
6.6 | IC50 | 3 | — | |
ONEKFAPECJXSTI
|
6.6 | IC50 | 3 | — |