Target Details
| UniProt AC | Q15759 |
|---|---|
| Gene Symbol | MAPK11 |
| Protein Name | Mitogen-activated protein kinase 11 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 594
- Clinical molecules 12
- Avg pChEMBL 7.22
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (594)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
BEUJQOCLEVYLAY
|
6.6 | IC50 | 5 | — | |
FMPGVEXFSHPKCI
|
6.6 | IC50 | 2 | — | |
HVIHYFPILKEGDC
|
6.6 | IC50 | 4 | — | |
NOZSDSJXKFXOND
|
6.6 | IC50 | 4 | — | |
ODRLAMBXHIQELH
|
6.6 | IC50 | 4 | — | |
PURIVPGRKIUWCS
|
6.6 | IC50 | 3 | — | |
RXVCNLNARLCLHQ
|
6.6 | IC50 | 2 | — | |
SAZVRXTVWZAHBI
|
6.6 | IC50 | 4 | — | |
SBYHQPVTFYWZBH
|
6.6 | IC50 | 4 | — | |
VMXSEPFINSQWTF
|
6.6 | IC50 | 4 | — | |
VTSREPAEERGWTC
|
6.6 | IC50 | 2 | — | |
XIPYKUQAZQIESI
|
6.6 | IC50 | 2 | — | |
BHMOXCCTQPBFHP
|
6.6 | Kd | 4 | — | |
BHSHXBRDUHHNCK
|
6.6 | IC50 | 2 | — | |
DNJHLGWWUWJPCC
|
6.6 | IC50 | 4 | — | |
KAGRJXQMRBCHOF
|
6.6 | IC50 | 4 | — | |
OLQLDLCSHKXSDH
|
6.6 | IC50 | 4 | — | |
WDSCOALUHAJVNA
|
6.6 | IC50 | 4 | — | |
YPRJIJRXHSOAKK
|
6.6 | IC50 | 4 | — | |
KVSYGXJLPJDFLW
|
6.6 | IC50 | 2 | — | |
PHDKOVQUPZVSDQ
|
6.6 | IC50 | 4 | — | |
QEVXPGAJPJCDLY
|
6.6 | IC50 | 2 | — | |
QRUGPEXDQDKFIQ
|
6.6 | IC50 | 2 | — | |
SZLYSQJIZDNCQP
|
6.6 | IC50 | 4 | — | |
ZOZZCCRDTJOUDI
|
6.6 | IC50 | 4 | — | |
CPLKJAOVKQRYLU
|
6.5 | IC50 | 5 | — | |
MIFPZJRPCSILQA
|
6.5 | IC50 | 6 | — | |
PDLOZSUJEHDJCF
|
6.5 | IC50 | 4 | — | |
RVLYJVVEFFSPEX
|
6.5 | Kd | 4 | — | |
LMTOUHLEUVLGSR
|
6.5 | IC50 | 4 | — | |
MFWRRYPZURQIQM
|
6.5 | IC50 | 4 | — | |
ZZCMAOOBHIDTJN
|
6.5 | IC50 | 4 | — | |
AAMBBQYZAVUDRL
|
6.5 | IC50 | 4 | — | |
CECKFLSHKDGWGQ
|
6.5 | IC50 | 4 | — | |
GUZODAKISVJZOY
|
6.5 | IC50 | 6 | — | |
ITHPNVNBELRBSK
|
6.5 | IC50 | 4 | — | |
IVQRDNQHHJAUCS
|
6.5 | IC50 | 5 | — | |
LCHFDKBXIJPQQV
|
6.5 | IC50 | 4 | — | |
RRTXHGDCNJPJLH
|
6.5 | IC50 | 4 | — | |
UJPJYIXFJSSTRL
|
6.5 | IC50 | 4 | — | |
VDIYQHFWCBWRJR
|
6.5 | IC50 | 5 | — | |
XTWOWJJHYIIJNI
|
6.5 | IC50 | 4 | — | |
INOXXLKTFTWBBH
|
6.5 | IC50 | 4 | — | |
LJNWACYTYAWEFK
|
6.5 | IC50 | 4 | — | |
OHMPXDCOVKOOAN
|
6.5 | IC50 | 4 | — | |
BVGHDOMJGHGNCJ
|
6.5 | IC50 | 2 | — | |
FDICHOOSBBHUQP
|
6.5 | Kd | 4 | — | |
HHFKNJQDPUOHBJ
|
6.5 | IC50 | 2 | — | |
VVGDYZAGZQTFBY
|
6.5 | IC50 | 4 | — | |
YCHQFRFMSZAMGH
|
6.5 | IC50 | 2 | — |