Target Details
| UniProt AC | Q15759 |
|---|---|
| Gene Symbol | MAPK11 |
| Protein Name | Mitogen-activated protein kinase 11 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 594
- Clinical molecules 12
- Avg pChEMBL 7.22
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (594)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WDMJITFYAJRAJW
|
7.2 | IC50 | 4 | — | |
YEQUJOKCSZTBFS
|
7.2 | IC50 | 4 | — | |
ZGXVMEYUYQMAQX
|
7.2 | IC50 | 4 | — | |
AKMUGCMCOYELTD
|
7.2 | IC50 | 4 | — | |
GDTQLZHHDRRBEB
|
7.2 | IC50 | 2 | — | |
HHCBMISMPSAZBF
|
7.2 | IC50 | 23 | — | |
AIAMQBKMZVAHHF
|
7.2 | IC50 | 4 | — | |
FMCXTTHVULYFDI
|
7.2 | IC50 | 4 | — | |
IFJJHTBJGFJLAS
|
7.2 | IC50 | 4 | — | |
KVIYSVXFZOEINO
|
7.2 | IC50 | 6 | — | |
PGUXJVJYJAXTTL
|
7.2 | IC50 | 4 | — | |
JYAWNXPPACKSCL
|
7.2 | IC50 | 4 | — | |
JNRDQHFKWJTGMW
|
7.1 | IC50 | 4 | — | |
NAAVOCGXGLOQSN
|
7.1 | IC50 | 2 | — | |
VEPKQEUBKLEPRA
|
7.1 | Kd | 11 | — | |
ZURAKXYJNNUPSM
|
7.1 | IC50 | 4 | — | |
MGCVZCZJPOZRQX
|
7.1 | IC50 | 4 | — | |
UBGIJAMGCVSDSG
|
7.1 | IC50 | 4 | — | |
BYRKVDOSQUAVAB
|
7.1 | IC50 | 5 | — | |
GDPTYJPHMSZXDA
|
7.1 | IC50 | 4 | — | |
HSIJDSUYWFNDTO
|
7.1 | IC50 | 4 | — | |
NJBOQGZRBOSMCW
|
7.1 | IC50 | 4 | — | |
QBACMJFLMUCPNA
|
7.1 | IC50 | 4 | — | |
UDVVJQVWAPEWSE
|
7.1 | IC50 | 4 | — | |
VXSHGJJXHHEQII
|
7.1 | IC50 | 4 | — | |
HTFVITLDAZUSJX
|
7.1 | IC50 | 4 | — | |
MFHMBFSCZDHKQA
|
7.1 | IC50 | 4 | — | |
CDMGBJANTYXAIV
|
7.1 | IC50 | 34 | Yes | |
YHVHYWYQEFELOW
|
7.1 | IC50 | 44 | — | |
OXYMFDZMUCACBM
|
7.1 | IC50 | 5 | — | |
QQJWMGJEEXBGSZ
|
7.1 | IC50 | 4 | — | |
BGIYKDUASORTBB
|
7.0 | IC50 | 6 | — | |
COVWDRBCMJOSQM
|
7.0 | IC50 | 5 | — | |
WBTZEYLGSORECL
|
7.0 | IC50 | 5 | — | |
YGBTVRUWFYRCNE
|
7.0 | IC50 | 4 | — | |
DIHFVAMILQNPTN
|
7.0 | IC50 | 4 | — | |
ZHDLFXBWQGXYPP
|
7.0 | IC50 | 4 | — | |
PXCDKWAUSFFTCC
|
7.0 | IC50 | 5 | — | |
VAARYSWULJUGST
|
7.0 | Kd | 119 | Yes | |
DKSOHNUQIJWTPQ
|
7.0 | IC50 | 4 | — | |
FNFFGFDJILZSOU
|
7.0 | IC50 | 2 | — | |
HSHCBSSOMDJQKJ
|
7.0 | IC50 | 4 | — | |
LCOSXCCYCLEMRH
|
7.0 | IC50 | 4 | — | |
OGGNYKNHAVTOTE
|
7.0 | IC50 | 4 | — | |
QHKYPYXTTXKZST
|
7.0 | IC50 | 28 | — | |
SZXJKSQEKRRTMT
|
7.0 | IC50 | 5 | — | |
UPYHVTCMTMZKAX
|
7.0 | IC50 | 12 | — | |
XBOAMGVRMOKHNU
|
7.0 | IC50 | 6 | — | |
XESVXURLFDSJCA
|
7.0 | IC50 | 4 | — | |
XTSFFHOZJOBYPO
|
7.0 | Kd | 4 | — |