Target Details
| UniProt AC | Q15759 |
|---|---|
| Gene Symbol | MAPK11 |
| Protein Name | Mitogen-activated protein kinase 11 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 594
- Clinical molecules 12
- Avg pChEMBL 7.22
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (594)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SNHWMEWYAPKRQL
|
7.8 | IC50 | 4 | — | |
WJTJZDOMFKCYEA
|
7.7 | IC50 | 6 | — | |
ZQXGAYYYCBUPSG
|
7.7 | IC50 | 2 | — | |
ZCCPLJOKGAACRT
|
7.7 | Kd | 599 | — | |
CQPNJQRTSADQCI
|
7.7 | IC50 | 2 | — | |
JVJCVRPAUUWRBH
|
7.7 | Kd | 4 | — | |
KCXCFBQZWGUDQC
|
7.7 | IC50 | 4 | — | |
LUZARSGELRSGPD
|
7.7 | IC50 | 4 | — | |
MWUPDRLQBJKIBA
|
7.7 | IC50 | 4 | — | |
KOCYTHSBSWIFSD
|
7.7 | IC50 | 5 | — | |
QGJNGXXVCVFADC
|
7.7 | IC50 | 2 | — | |
WZQMZQPCSYFLOE
|
7.7 | IC50 | 4 | — | |
FZAUNVRSNYGSRM
|
7.7 | Kd | 4 | — | |
CFXVMISMBBBSCO
|
7.7 | IC50 | 2 | — | |
FIGYKDVBCKXPEA
|
7.7 | Kd | 4 | — | |
AWHRFPLTQPNOTD
|
7.6 | IC50 | 5 | — | |
VGEXRDWWPSGZDH
|
7.6 | IC50 | 4 | — | |
AQXKGSIGOIIUJI
|
7.6 | IC50 | 4 | — | |
BOPSUAHGQHFKGG
|
7.6 | Ki | 3 | — | |
VOUFJXLXOWMZOG
|
7.6 | IC50 | 4 | — | |
BIWWSRSPBBUSCN
|
7.6 | Kd | 2 | — | |
DHNYNLNKNQJSHF
|
7.6 | Kd | 4 | — | |
KKYABQBFGDZVNQ
|
7.6 | Ki | 4 | — | |
RGWJYCCSHANDCO
|
7.6 | IC50 | 2 | — | |
ZWQSPUPMQMBACD
|
7.6 | Ki | 2 | — | |
XPWLTGRNORHARK
|
7.6 | IC50 | 4 | — | |
TWWUNSJOKCOGKZ
|
7.6 | IC50 | 4 | — | |
FEGPYUXSDDPKOY
|
7.6 | IC50 | 5 | — | |
WLSRUNCRTNITTJ
|
7.6 | IC50 | 4 | — | |
WYGVFMIQQCLMNX
|
7.5 | IC50 | 4 | — | |
YKUDVEVHRUJXLV
|
7.5 | IC50 | 5 | — | |
GZPYMRRCHNCWPW
|
7.5 | IC50 | 4 | — | |
IWYYBVHHQRNVMT
|
7.5 | IC50 | 2 | — | |
KKKRKRMVJRHDMG
|
7.5 | Kd | 14 | — | |
YRJCGFIHLVCSEO
|
7.5 | IC50 | 2 | — | |
GWAMNECAZIXYSS
|
7.5 | IC50 | 4 | — | |
GYQLVKWGHKBDMP
|
7.5 | IC50 | 6 | — | |
UOGQEKVLZDBJDM
|
7.5 | IC50 | 4 | — | |
XIPLZPXJTFHKRP
|
7.5 | IC50 | 4 | — | |
ZQJQDDLGWSLWNG
|
7.5 | IC50 | 4 | — | |
HIVGXEUXJUXVAR
|
7.5 | IC50 | 2 | — | |
HOTOPLMUHTWMOS
|
7.5 | Kd | 4 | — | |
HXMGCTFLLWPVFM
|
7.5 | IC50 | 6 | — | |
HXNUFFCHRIWTRZ
|
7.5 | IC50 | 5 | — | |
NKIIJQFBQXIXNY
|
7.5 | IC50 | 4 | — | |
VSPFURGQAYMVAN
|
7.5 | IC50 | 17 | — | |
QIBLVZMAUUVSMB
|
7.5 | IC50 | 4 | — | |
SFXQPCGNFSUNGU
|
7.5 | IC50 | 4 | — | |
CZEBZOHAXRSHBJ
|
7.4 | IC50 | 4 | — | |
HHZIURLSWUIHRB
|
7.4 | Kd | 57 | Yes |