Target Details
| UniProt AC | Q15759 |
|---|---|
| Gene Symbol | MAPK11 |
| Protein Name | Mitogen-activated protein kinase 11 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 594
- Clinical molecules 12
- Avg pChEMBL 7.22
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (594)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AWSZCHFRHWSLPN
|
6.3 | IC50 | 4 | — | |
CBPLDNYLJICMAR
|
6.3 | Kd | 4 | — | |
FJUIICXYIIRUCU
|
6.3 | IC50 | 4 | — | |
LRXMSYVOXXQDBJ
|
6.3 | IC50 | 4 | — | |
MAWRDJKYIIEEBO
|
6.3 | IC50 | 4 | — | |
NGBQSNGTCAJHFD
|
6.3 | IC50 | 4 | — | |
QFMUQVZWWIIJOR
|
6.3 | IC50 | 4 | — | |
QUHUYHMRDJMTMH
|
6.3 | IC50 | 2 | — | |
VHTRWSPDJZQIRM
|
6.3 | IC50 | 4 | — | |
WCLWBZMXDKHZAL
|
6.3 | IC50 | 4 | — | |
JUSVEWRLNMHNJO
|
6.3 | IC50 | 4 | — | |
JWYBOCFZMDDWKU
|
6.3 | IC50 | 2 | — | |
BJXGEYDZUISYLS
|
6.3 | IC50 | 5 | — | |
IAROMOZGTJIMAY
|
6.3 | IC50 | 4 | — | |
JQDHHMODXIURJP
|
6.3 | IC50 | 4 | — | |
KRYNJPWYYDQKNN
|
6.3 | Kd | 4 | — | |
SIQZVZWIOHSCAK
|
6.3 | IC50 | 2 | — | |
VDKRYSKRXSNRGS
|
6.3 | IC50 | 4 | — | |
WJKXYGGZKSIWQJ
|
6.3 | IC50 | 2 | — | |
AKUKHICVNCCQHN
|
6.3 | IC50 | 2 | — | |
ARAZWGAZTSHNHP
|
6.3 | IC50 | 2 | — | |
CYCXCKOESWCLST
|
6.3 | IC50 | 5 | — | |
ITOPOIHCBBHSIR
|
6.3 | IC50 | 4 | — | |
XPYOCUNKDACBLQ
|
6.3 | IC50 | 2 | — | |
KVBWUPVGVUIAIX
|
6.2 | IC50 | 2 | — | |
PRYUWQSCZBKGMW
|
6.2 | IC50 | 4 | — | |
TVBDBLCHNYCOHL
|
6.2 | IC50 | 4 | — | |
DZVQBRGQNWDWIG
|
6.2 | IC50 | 6 | — | |
QXROCLPRKWUYBA
|
6.2 | IC50 | 5 | — | |
BILJSHVAAVZERY
|
6.2 | Ki | 4 | — | |
CYGBQFZNIADYFY
|
6.2 | IC50 | 4 | — | |
OLFNUOKBBIASKG
|
6.2 | IC50 | 2 | — | |
VPDKNFFYTVLJND
|
6.2 | IC50 | 4 | — | |
GEKFGZAQUSKHQW
|
6.2 | IC50 | 4 | — | |
AGENJCIJABIKKO
|
6.2 | IC50 | 4 | — | |
IKQIPPKRAFLUKQ
|
6.2 | IC50 | 4 | — | |
JDVWDZJXQUCOPW
|
6.2 | IC50 | 4 | — | |
NLHYRLRQFAKAFM
|
6.2 | IC50 | 4 | — | |
BMLURWVFPXQDFS
|
6.2 | IC50 | 4 | — | |
RBBGYRNIIDIURS
|
6.2 | IC50 | 2 | — | |
RDRRLTKYMVDKDE
|
6.2 | IC50 | 5 | — | |
RDUXJEGWTNOYDA
|
6.2 | IC50 | 6 | — | |
YTGWXEIUYWQLJS
|
6.2 | IC50 | 4 | — | |
GVGLHMXYNVASQP
|
6.2 | IC50 | 4 | — | |
QHNXZMWGDCUUFW
|
6.2 | IC50 | 2 | — | |
VWMJHAFYPMOMGF
|
6.2 | Kd | 15 | — | |
XUJXJGOYKOTUOC
|
6.2 | IC50 | 4 | — | |
HBJKNJVTHNFOON
|
6.2 | IC50 | 4 | — | |
NMEUKWOOQOHUNA
|
6.2 | IC50 | 6 | — | |
OKGRQZVTGRLIKW
|
6.2 | IC50 | 4 | — |