Target Details
| UniProt AC | Q14957 |
|---|---|
| Gene Symbol | GRIN2C |
| Protein Name | Glutamate receptor ionotropic, NMDA 2C |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01094 (ANF_receptor) PF00060 (Lig_chan) PF10613 (Lig_chan-Glu_bd) PF10565 (NMDAR2_C) |
Summary
- Multi-target molecules 243
- Clinical molecules 1
- Avg pChEMBL 7.23
KEGG Pathways (16)
- Alcoholism
- Alzheimer disease
- Amphetamine addiction
- Amyotrophic lateral sclerosis
- Calcium signaling pathway
- Circadian entrainment
- Cocaine addiction
- Glutamatergic synapse
- Long-term potentiation
- Neuroactive ligand signaling
- Neuroactive ligand-receptor interaction
- Nicotine addiction
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Spinocerebellar ataxia
- cAMP signaling pathway
Active Molecules (243)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RYQDODXKZXMXRZ
|
6.8 | Ki | 3 | — | |
VOROEQBFPPIACJ
|
6.8 | IC50 | 7 | — | |
YQEZLKZALYSWHR
|
6.8 | Ki | 7 | — | |
QDOWQPQWJXJCRA
|
6.7 | Ki | 7 | — | |
SUVNEFNZAWETBP
|
6.7 | Ki | 7 | — | |
FYGULVAWGIBPEL
|
6.7 | IC50 | 7 | — | |
IFDCSWVGBHHTOK
|
6.7 | IC50 | 7 | — | |
JAQUASYNZVUNQP
|
6.7 | Ki | 8 | — | |
JYADRHLCOIWTSM
|
6.7 | Ki | 3 | — | |
KLCJMNXGNQFUAQ
|
6.7 | IC50 | 7 | — | |
QIULADNIPAPHOG
|
6.7 | IC50 | 7 | — | |
QUZDDEHHDSCFBO
|
6.7 | Ki | 3 | — | |
SAPQZYMPGUOQOF
|
6.7 | IC50 | 8 | — | |
RODJWDCTFWIGQR
|
6.6 | Ki | 7 | — | |
BFMVLFRBLSHGFU
|
6.6 | IC50 | 8 | — | |
DHJQWBSZKBDBFP
|
6.6 | IC50 | 7 | — | |
YHHDPWJZYRBKJE
|
6.6 | IC50 | 7 | — | |
AXLDVANRUJQULH
|
6.6 | Ki | 7 | — | |
PGDDLNGALMYVNU
|
6.6 | IC50 | 7 | — | |
DHJQWBSZKBDBFP
|
6.6 | IC50 | 7 | — | |
PWAWBYGMUYUAIE
|
6.6 | Ki | 7 | — | |
SLRJZCSXCAIAOA
|
6.6 | Ki | 3 | — | |
SYCPILSKZWDGPU
|
6.6 | Ki | 7 | — | |
VWRBMYVRTNAYKU
|
6.6 | Ki | 3 | — | |
BNMGAKYFGHEJFA
|
6.6 | IC50 | 7 | — | |
KCNBAUKGODRNGM
|
6.6 | IC50 | 8 | — | |
YCKWYXZBMJSNNJ
|
6.6 | IC50 | 7 | — | |
DBSHFABBWSZJLZ
|
6.5 | IC50 | 7 | — | |
IPIYGYRWMPIQNA
|
6.5 | IC50 | 7 | — | |
DHJQWBSZKBDBFP
|
6.5 | IC50 | 7 | — | |
MKXZASYAUGDDCJ
|
6.5 | IC50 | 8 | — | |
RIAXXCQKICATHW
|
6.5 | IC50 | 8 | — | |
AFLMEDYILBVTLD
|
6.5 | IC50 | 7 | — | |
BVMISDVPLOGTCO
|
6.4 | Ki | 3 | — | |
CUVGUPIVTLGRGI
|
6.4 | IC50 | 7 | — | |
XOTFPBSIGVOVNZ
|
6.4 | IC50 | 7 | — | |
MZBASFPGAJKZGV
|
6.4 | IC50 | 7 | — | |
BFMVLFRBLSHGFU
|
6.4 | Ki | 7 | — | |
IWBBGNZPEIAVFV
|
6.4 | IC50 | 7 | — | |
JHKKCDOQENTIHK
|
6.4 | Ki | 7 | — | |
PDWIXUPKLCRNMD
|
6.4 | Ki | 7 | — | |
YYRFNNUNFMRYPC
|
6.4 | Ki | 7 | — | |
SGEHBQYHDGXTNO
|
6.4 | IC50 | 5 | — | |
ZRBNLIHXVISUQQ
|
6.4 | IC50 | 7 | — | |
LWFDMVFVKWWYFN
|
6.3 | IC50 | 7 | — | |
MYDMWESTDPJANS
|
6.3 | IC50 | 8 | — | |
RARPYAVALSABGF
|
6.3 | IC50 | 7 | — | |
XFAHIODKMNWZPL
|
6.3 | IC50 | 7 | — | |
ZAAIRIXWNJOFIN
|
6.3 | IC50 | 7 | — | |
GJRPFDMAMNUCGJ
|
6.3 | Ki | 3 | — |