Target Details
| UniProt AC | Q14790 |
|---|---|
| Gene Symbol | CASP8 |
| Protein Name | Caspase-8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01335 (DED) PF00656 (Peptidase_C14) |
Summary
- Multi-target molecules 219
- Clinical molecules 0
- Avg pChEMBL 7.45
KEGG Pathways (37)
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- C-type lectin receptor signaling pathway
- Chagas disease
- Cytosolic DNA-sensing pathway
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Huntington disease
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Legionellosis
- Lipid and atherosclerosis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Non-alcoholic fatty liver disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Platinum drug resistance
- RIG-I-like receptor signaling pathway
- Salmonella infection
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
- Viral myocarditis
- p53 signaling pathway
Associated Diseases (2)
Active Molecules (219)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MEOSEAYZHVITJF
|
6.2 | IC50 | 3 | — | |
IJQPLPVGYLMXIU
|
6.2 | IC50 | 2 | — | |
LDDAWLZYJRJPPR
|
6.2 | IC50 | 4 | — | |
PZMBYHSWPUMKMR
|
6.2 | Ki | 3 | — | |
ASGHIPSJIOETFI
|
6.1 | IC50 | 2 | — | |
GCIXFQFILPSHQY
|
6.1 | IC50 | 3 | — | |
UVJNVVPTQWFZMT
|
6.1 | IC50 | 4 | — | |
AYQUXMOMSNPZEF
|
6.1 | Ki | 4 | — | |
NQNOSUGXDKSHRE
|
6.1 | IC50 | 3 | — | |
URMGPEOQLIISAB
|
6.1 | Ki | 4 | — | |
CXBBLGYLOAZXJT
|
6.1 | IC50 | 5 | — | |
BZEURKGKCWHMON
|
6.1 | Ki | 4 | — | |
YEUTYABUIBVFMW
|
6.0 | IC50 | 2 | — | |
ITXGNTGSRFVVNR
|
6.0 | IC50 | 2 | — | |
OEMJCZSXKAMRQI
|
6.0 | IC50 | 2 | — | |
HWKXAKRQXXUBFD
|
6.0 | IC50 | 3 | — | |
HWKXAKRQXXUBFD
|
6.0 | IC50 | 3 | — | |
JMCSMHDKXZIFQR
|
6.0 | IC50 | 4 | — | |
VIUJQQJJJZNKDP
|
6.0 | IC50 | 4 | — |