Target Details
| UniProt AC | Q14790 |
|---|---|
| Gene Symbol | CASP8 |
| Protein Name | Caspase-8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01335 (DED) PF00656 (Peptidase_C14) |
Summary
- Multi-target molecules 219
- Clinical molecules 0
- Avg pChEMBL 7.45
KEGG Pathways (37)
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- C-type lectin receptor signaling pathway
- Chagas disease
- Cytosolic DNA-sensing pathway
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Huntington disease
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Legionellosis
- Lipid and atherosclerosis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Non-alcoholic fatty liver disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Platinum drug resistance
- RIG-I-like receptor signaling pathway
- Salmonella infection
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
- Viral myocarditis
- p53 signaling pathway
Associated Diseases (2)
Active Molecules (219)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FMTZTJFXNZOBIQ
|
6.8 | Ki | 5 | — | |
JSLLIKPZGONZEJ
|
6.8 | IC50 | 2 | — | |
YJVZPPRMAGBWFR
|
6.8 | Ki | 2 | — | |
CBORVVSGKICHTH
|
6.8 | IC50 | 2 | — | |
UUEMWRIOZLIPHU
|
6.8 | IC50 | 4 | — | |
UUEMWRIOZLIPHU
|
6.8 | IC50 | 4 | — | |
WTDVEFVYINBNSI
|
6.8 | Ki | 3 | — | |
CUDGJBLALZRKFR
|
6.8 | IC50 | 3 | — | |
SGVNFLQYMIJSSK
|
6.8 | IC50 | 3 | — | |
JPRMMEXMBCGVFV
|
6.7 | IC50 | 2 | — | |
NLZNSSWGRVBWIX
|
6.7 | IC50 | 4 | — | |
IMKLAZABQHZAJN
|
6.6 | IC50 | 2 | — | |
QPXWSOVNNLBWQP
|
6.6 | IC50 | 2 | — | |
ASXOTWMUUUHDST
|
6.5 | IC50 | 2 | — | |
STDJONDOUCKJSO
|
6.5 | IC50 | 3 | — | |
STDJONDOUCKJSO
|
6.5 | IC50 | 3 | — | |
OZAFISSWLZQMIS
|
6.5 | IC50 | 5 | — | |
IYNNJMRCPJPTMI
|
6.5 | IC50 | 3 | — | |
WUQPWSWGFKLLRA
|
6.5 | IC50 | 2 | — | |
ZSOPKWJQJKUHFH
|
6.5 | IC50 | 2 | — | |
ZOVHWLRITDMPBF
|
6.5 | Ki | 3 | — | |
AFVSWIIKNZNPMC
|
6.5 | IC50 | 2 | — | |
MZDVCOYYTAHLOR
|
6.5 | Ki | 3 | — | |
DGOJTUAQSDYETG
|
6.4 | IC50 | 2 | — | |
HBVXRUIPTGRFDT
|
6.4 | IC50 | 2 | — | |
CIDFSOFEWVUWHQ
|
6.4 | IC50 | 4 | — | |
RYTHJGWSBNDVTE
|
6.4 | IC50 | 2 | — | |
NKBDSMREMMRFSI
|
6.4 | IC50 | 5 | — | |
NKBDSMREMMRFSI
|
6.4 | IC50 | 5 | — | |
WNMPCOLHJBPQIT
|
6.4 | IC50 | 2 | — | |
RIHVWVMASFXAPK
|
6.3 | IC50 | 2 | — | |
VURUGTWAAZWTEC
|
6.3 | IC50 | 2 | — | |
ZYWFKPCNVPPHDB
|
6.3 | IC50 | 2 | — | |
GEGJGGLPPHXVSY
|
6.3 | Ki | 3 | — | |
RIZGIRHQBSAXIW
|
6.3 | Ki | 2 | — | |
ZJOMIVVGRLRQHB
|
6.3 | IC50 | 2 | — | |
YBUQKGADXMDZCC
|
6.3 | IC50 | 2 | — | |
QENZECCKNUZHEO
|
6.3 | IC50 | 3 | — | |
YPSFOQSJNMXHOO
|
6.3 | IC50 | 2 | — | |
CBORVVSGKICHTH
|
6.3 | IC50 | 2 | — | |
DOBIYIOPZIMMRH
|
6.3 | Ki | 3 | — | |
YAXZZOWMNVKCTF
|
6.3 | IC50 | 2 | — | |
XNELIBGPKZNEOG
|
6.2 | IC50 | 5 | — | |
IOVDCXCEGWOHSX
|
6.2 | IC50 | 2 | — | |
NPQYORAPVDDBMZ
|
6.2 | IC50 | 5 | — | |
NPQYORAPVDDBMZ
|
6.2 | IC50 | 5 | — | |
XQRCYZUOALTFCB
|
6.2 | IC50 | 2 | — | |
WLZOCGMSLPOOIC
|
6.2 | IC50 | 4 | — | |
ZPGKPGJAPADYFS
|
6.2 | Ki | 2 | — | |
MEOSEAYZHVITJF
|
6.2 | IC50 | 3 | — |