Target Details
| UniProt AC | Q14643 |
|---|---|
| Gene Symbol | ITPR1 |
| Protein Name | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF08709 (Ins145_P3_rec) PF00520 (Ion_trans) PF02815 (MIR) PF08454 (RIH_assoc) PF01365 (RYDR_ITPR) |
Summary
- Multi-target molecules 4
- Clinical molecules 0
- Avg pChEMBL 7.51
KEGG Pathways (50)
- Aldosterone synthesis and secretion
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Calcium signaling pathway
- Cellular senescence
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dopaminergic synapse
- Estrogen signaling pathway
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- NOD-like receptor signaling pathway
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways of neurodegeneration - multiple diseases
- Phosphatidylinositol signaling system
- Platelet activation
- Prion disease
- Proteoglycans in cancer
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Shigellosis
- Spinocerebellar ataxia
- Thyroid hormone synthesis
- Vascular smooth muscle contraction
- cGMP-PKG signaling pathway
Associated Diseases (2)
Active Molecules (4)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JZUCYWKEUXTJPF
|
8.9 | Kd | 2 | — | |
CIPFCGZLFXVXBG
|
7.7 | IC50 | 3 | — | |
DMSJBTPCWTWRKQ
|
6.8 | IC50 | 3 | — | |
MMWCIQZXVOZEGG
|
6.6 | IC50 | 3 | — |