Target Details
| UniProt AC | Q14457 |
|---|---|
| Gene Symbol | BECN1 |
| Protein Name | Beclin-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF04111 (APG6) PF17675 (APG6_N) PF15285 (BH3) |
Summary
- Multi-target molecules 7
- Clinical molecules 0
- Avg pChEMBL 6.43
KEGG Pathways (12)
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apelin signaling pathway
- Apoptosis - multiple species
- Autophagy - animal
- Autophagy - other
- Huntington disease
- Kaposi sarcoma-associated herpesvirus infection
- Mitophagy - animal
- Pathways of neurodegeneration - multiple diseases
- Shigellosis
- Spinocerebellar ataxia
Top Co-occurrence Targets
- BCL2 7 shared
Active Molecules (7)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SUEZXPXGAIMTGO
|
6.8 | IC50 | 2 | — | |
OJUMKZIPNGXHIF
|
6.7 | IC50 | 2 | — | |
VSQXKEVSUSRVLZ
|
6.6 | IC50 | 2 | — | |
SCGWKBMWFSPEHE
|
6.5 | IC50 | 2 | — | |
LIFKHVYNXCOOCC
|
6.3 | IC50 | 2 | — | |
AEYNPQNDSFSVNF
|
6.0 | IC50 | 2 | — | |
SHUCWWLORPYDRA
|
6.0 | IC50 | 2 | — |