Target Details
| UniProt AC | Q13936 |
|---|---|
| Gene Symbol | CACNA1C |
| Protein Name | Voltage-dependent L-type calcium channel subunit alpha-1C |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF08763 (Ca_chan_IQ) PF16885 (CAC1F_C) PF16905 (GPHH) PF00520 (Ion_trans) |
Summary
- Multi-target molecules 147
- Clinical molecules 5
- Avg pChEMBL 7.6
KEGG Pathways (34)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Cardiac muscle contraction
- Chemical carcinogenesis - receptor activation
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hypertrophic cardiomyopathy
- Insulin secretion
- Long-term potentiation
- MAPK signaling pathway
- Oxytocin signaling pathway
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Taste transduction
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (3)
Active Molecules (147)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CCSNTESBCKUCEA
|
6.8 | IC50 | 4 | — | |
IGTBNUVMBDYPQG
|
6.8 | Ki | 8 | — | |
ZMRQKZANSRISRS
|
6.8 | IC50 | 3 | — | |
SGTNSNPWRIOYBX
|
6.8 | IC50 | 19 | — | |
YRBFVPQLCITKOD
|
6.8 | IC50 | 2 | — | |
YVUQSNJEYSNKRX
|
6.7 | IC50 | 36 | — | |
RJHIEGFHLJUYSA
|
6.7 | IC50 | 5 | — | |
HCEKERAQUTWNGZ
|
6.7 | IC50 | 2 | — | |
HBNPJJILLOYFJU
|
6.6 | IC50 | 21 | — | |
FLNYLINBEZROPL
|
6.6 | IC50 | 6 | — | |
ZBBHBTPTTSWHBA
|
6.6 | IC50 | 5 | — | |
IYIKLHRQXLHMJQ
|
6.6 | IC50 | 18 | — | |
RGUQEIQNPDMTLR
|
6.6 | IC50 | 4 | — | |
RVBQIBMRQBVLMH
|
6.6 | IC50 | 4 | — | |
GALCSZPFCCZIBC
|
6.5 | IC50 | 20 | Yes | |
NZSMHVGBSNDKDO
|
6.5 | IC50 | 4 | — | |
NXCFKLLOEZTCHO
|
6.5 | Ki | 4 | — | |
FRFNLRPRBZSCOW
|
6.5 | IC50 | 2 | — | |
OZBPEBNJOSXIBE
|
6.4 | IC50 | 2 | — | |
DXHGSDDDNQXAEJ
|
6.4 | IC50 | 26 | — | |
HQBVENHUOCSWIS
|
6.4 | IC50 | 2 | — | |
ITXUJDTVHQVSLI
|
6.4 | IC50 | 2 | — | |
MLDXNVWBLNAZSD
|
6.4 | IC50 | 2 | — | |
CAFYOFMRFOIFOW
|
6.4 | IC50 | 2 | — | |
BGWZTGQTWNIEFA
|
6.3 | IC50 | 2 | — | |
ITXUJDTVHQVSLI
|
6.3 | IC50 | 2 | — | |
HKKFCFIFPDLOKD
|
6.3 | IC50 | 4 | — | |
BGWZTGQTWNIEFA
|
6.3 | IC50 | 2 | — | |
SKVXOYIMICHFPV
|
6.3 | IC50 | 10 | Yes | |
HSUGRBWQSSZJOP
|
6.2 | IC50 | 5 | — | |
UYZIPLMTFSGKAJ
|
6.2 | IC50 | 5 | — | |
HQBVENHUOCSWIS
|
6.2 | IC50 | 2 | — | |
VNFPBHJOKIVQEB
|
6.2 | IC50 | 20 | Yes | |
CGEFSAWBLMCMJR
|
6.2 | IC50 | 4 | — | |
UZBVUMAEAIQRKF
|
6.2 | IC50 | 4 | — | |
MLDXNVWBLNAZSD
|
6.2 | IC50 | 2 | — | |
CVFBVSUFNWOPLD
|
6.1 | IC50 | 6 | — | |
FJMAUPWFRMSLJB
|
6.1 | IC50 | 2 | — | |
XKDFZZUFCHOVRN
|
6.1 | IC50 | 27 | — | |
NFBNIRNKYJTDIE
|
6.1 | IC50 | 16 | Yes | |
PYXDWIWBQXUGPX
|
6.1 | IC50 | 3 | — | |
SAFUGOIRFHJACA
|
6.0 | IC50 | 4 | — | |
GUGOEEXESWIERI
|
6.0 | IC50 | 18 | Yes | |
KYAGVGRXHALGSE
|
6.0 | IC50 | 5 | — | |
HMXDWDSNPRNUKI
|
6.0 | Ki | 72 | — | |
UIEATEWHFDRYRU
|
6.0 | IC50 | 3 | — | |
UIEATEWHFDRYRU
|
6.0 | IC50 | 8 | — |