Target Details
| UniProt AC | Q13936 |
|---|---|
| Gene Symbol | CACNA1C |
| Protein Name | Voltage-dependent L-type calcium channel subunit alpha-1C |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF08763 (Ca_chan_IQ) PF16885 (CAC1F_C) PF16905 (GPHH) PF00520 (Ion_trans) |
Summary
- Multi-target molecules 147
- Clinical molecules 5
- Avg pChEMBL 7.6
KEGG Pathways (34)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Cardiac muscle contraction
- Chemical carcinogenesis - receptor activation
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hypertrophic cardiomyopathy
- Insulin secretion
- Long-term potentiation
- MAPK signaling pathway
- Oxytocin signaling pathway
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Taste transduction
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (3)
Active Molecules (147)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IXIXBYHIWIUFLB
|
7.8 | IC50 | 4 | — | |
YZIYDQGNWSHQSD
|
7.8 | IC50 | 26 | — | |
ZMYGBEMRHGJETO
|
7.8 | IC50 | 26 | — | |
NOCIOWGNSBLDHC
|
7.8 | IC50 | 26 | — | |
NWSFHJWTWBRJFA
|
7.8 | IC50 | 26 | — | |
NVLFDWLIOVSYAF
|
7.8 | IC50 | 4 | — | |
UJPHXNFMWVCEBX
|
7.8 | IC50 | 4 | — | |
RKTLPLNLALGPKT
|
7.8 | Ki | 4 | — | |
ZTKAJVXFDWQBSJ
|
7.7 | IC50 | 3 | — | |
CLSLOWKHEUDMRP
|
7.7 | IC50 | 26 | — | |
HYIMSNHJOBLJNT
|
7.7 | IC50 | 6 | — | |
AYXYPKUFHZROOJ
|
7.6 | IC50 | 3 | — | |
ZTNBOUBFOFURTR
|
7.6 | IC50 | 26 | — | |
BDMBSHGVIWYMFZ
|
7.6 | IC50 | 26 | — | |
LFBPUPJLIZDNMB
|
7.6 | IC50 | 4 | — | |
ZVUQWPQXEDQMQO
|
7.6 | IC50 | 4 | — | |
BDZDJFPQRUGPOF
|
7.5 | IC50 | 26 | — | |
BVNRYPXFJUABAB
|
7.5 | IC50 | 26 | — | |
KHNYTFYQPKVXKP
|
7.5 | Ki | 4 | — | |
KNZXTLGWVGHSPA
|
7.5 | Ki | 4 | — | |
NRQIYYZXZYUWFB
|
7.5 | IC50 | 26 | — | |
VLKBVXIFTQLGCO
|
7.5 | IC50 | 26 | — | |
MVUOEDQURQKALH
|
7.5 | IC50 | 26 | — | |
PSVKDIGKMXLUQF
|
7.5 | IC50 | 26 | — | |
IXSXSOMMKYUETH
|
7.5 | IC50 | 26 | — | |
FFLKWIPCJQAAJX
|
7.4 | IC50 | 26 | — | |
IYDRYGWSROLZSY
|
7.4 | Ki | 4 | — | |
MUMGGOZAMZWBJJ
|
7.4 | IC50 | 6 | — | |
QRGMHEOPAKSEPT
|
7.4 | IC50 | 26 | — | |
UMDPFCNSBNGNBU
|
7.4 | IC50 | 26 | — | |
QWTOYMMBYIZUDZ
|
7.4 | IC50 | 26 | — | |
NMUYSGNBSUTZOC
|
7.3 | IC50 | 4 | — | |
ZWJKOWFFHJCZRL
|
7.3 | IC50 | 26 | — | |
CYYZSIFPMQWUQM
|
7.3 | IC50 | 4 | — | |
DTPINYZLNUJBJO
|
7.2 | Ki | 4 | — | |
XNUZTIQWJMXUHN
|
7.2 | IC50 | 26 | — | |
AZSLSVQTOKQPLV
|
7.2 | IC50 | 26 | — | |
CHDZSBDHFQDYBD
|
7.1 | Ki | 4 | — | |
BQQHWRLQVWTKDU
|
7.1 | IC50 | 26 | — | |
QKEPYKVCOWFCDP
|
7.1 | IC50 | 26 | — | |
YFOFVZPUHCDYSB
|
7.1 | IC50 | 4 | — | |
RTFHWULQHQDWPK
|
7.0 | IC50 | 26 | — | |
OKGUKEIPHKTCKR
|
7.0 | IC50 | 4 | — | |
UIAGMCDKSXEBJQ
|
7.0 | IC50 | 4 | — | |
KFBQDAJEXXORSH
|
6.9 | IC50 | 4 | — | |
FOBFICSYUINKAA
|
6.9 | IC50 | 6 | — | |
GERVYTOORWZGGL
|
6.8 | IC50 | 2 | — | |
HPTXPZUMVHDFCW
|
6.8 | IC50 | 4 | — | |
PTQTUHGWGGIJET
|
6.8 | Ki | 4 | — | |
HCEKERAQUTWNGZ
|
6.8 | IC50 | 2 | — |