Target Details
| UniProt AC | Q13547 |
|---|---|
| Gene Symbol | HDAC1 |
| Protein Name | Histone deacetylase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00850 (Hist_deacetyl) |
Summary
- Multi-target molecules 5,940
- Clinical molecules 933
- Avg pChEMBL 7.19
KEGG Pathways (18)
- ATP-dependent chromatin remodeling
- Alcoholism
- Amphetamine addiction
- Cell cycle
- Chronic myeloid leukemia
- Epstein-Barr virus infection
- Human papillomavirus infection
- Huntington disease
- Longevity regulating pathway - multiple species
- MicroRNAs in cancer
- Neutrophil extracellular trap formation
- Notch signaling pathway
- Pathways in cancer
- Polycomb repressive complex
- TGF-beta signaling pathway
- Thyroid hormone signaling pathway
- Transcriptional misregulation in cancer
- Viral carcinogenesis
Active Molecules (5,940)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UPCFDQLGZODPFB
|
11.8 | pIC50 | 10 | Yes | |
KASXKFPWIZYBSG
|
10.7 | pIC50 | 11 | Yes | |
JWOGUUIOCYMBPV
|
10.4 | pIC50 | 17 | Yes | |
UHEYNWPVMPFABG
|
10.3 | IC50 | 4 | — | |
LBLZRRPKVKWPQM
|
10.3 | IC50 | 4 | — | |
NJPJWEDRLRTSLU
|
10.2 | pIC50 | 11 | Yes | |
VFRCRJVXJIJVMW
|
10.1 | pIC50 | 11 | Yes | |
KTDMUZVIKYUDSP
|
10.1 | IC50 | 4 | — | |
XOIHZLRGDVDAIX
|
10.1 | IC50 | 4 | — | |
CHYLWOLPEHCRFO
|
10.0 | pIC50 | 5 | Yes | |
DLLHJBHGTGLQMS
|
10.0 | IC50 | 4 | — | |
FBOIQKKEKYJGGI
|
10.0 | pIC50 | 6 | Yes | |
YNOXQYPNBSQQEI
|
10.0 | IC50 | 5 | — | |
BMXJAODDXNZAPY
|
10.0 | IC50 | 3 | — | |
LIFSXYRTQZMHIJ
|
10.0 | IC50 | 4 | — | |
NCCVAHRKWSHQQH
|
10.0 | pIC50 | 12 | Yes | |
VEAQOZPEFGLUBX
|
10.0 | IC50 | 4 | — | |
VYLGTNTVBFZHQA
|
10.0 | pIC50 | 11 | Yes | |
ZUOQPJWZUKPUSH
|
10.0 | IC50 | 4 | — | |
GXYPZZICISCPIH
|
9.9 | IC50 | 4 | — | |
MEJLVLMAJJRLCR
|
9.9 | IC50 | 6 | — | |
JMHJAMQXSRNSJH
|
9.9 | IC50 | 4 | — | |
YPUXXFACVMXKLC
|
9.9 | IC50 | 4 | — | |
GTIGKFJXZOXXGI
|
9.8 | IC50 | 4 | — | |
LGPQOPUHRTXZTJ
|
9.8 | IC50 | 4 | — | |
SUNGABODFFTHQQ
|
9.8 | IC50 | 4 | — | |
RTKIYFITIVXBLE
|
9.8 | pIC50 | 17 | Yes | |
NWSMVLJLEXXRHR
|
9.8 | IC50 | 5 | — | |
PRXXYMVLYKJITB
|
9.8 | IC50 | 4 | — | |
RUZAXWOLPJIQDT
|
9.8 | IC50 | 4 | — | |
SAAIALQMXUSENU
|
9.8 | IC50 | 2 | — | |
WOGPSXAJPRAXBA
|
9.8 | Ki | 8 | — | |
MEXBWEBSXKCCSI
|
9.8 | IC50 | 4 | — | |
BADFSASMAVQGKQ
|
9.7 | IC50 | 4 | — | |
HTJJCAXHIUJXFI
|
9.7 | IC50 | 4 | — | |
KYKNGFDAIMGGRS
|
9.7 | IC50 | 4 | — | |
MIIVFFJEPMFGSH
|
9.7 | IC50 | 4 | — | |
TXYMAYROIBOVDM
|
9.7 | IC50 | 4 | — | |
LHNROLRKNQLRIY
|
9.7 | IC50 | 4 | — | |
MYGVGPGFPDQQRX
|
9.7 | IC50 | 4 | — | |
YPXRCUVTZDXVHY
|
9.7 | IC50 | 7 | — | |
AEDUBEGTPWKDCX
|
9.7 | IC50 | 6 | — | |
AHMDLJINAVKCDM
|
9.7 | IC50 | 2 | — | |
BTCGBXANODJFOB
|
9.7 | IC50 | 3 | — | |
BWTPSSSOMLHHKD
|
9.7 | IC50 | 3 | — | |
HBMZYQFZVBDYHR
|
9.7 | IC50 | 2 | — | |
HCEDLZCUHOEHNH
|
9.7 | IC50 | 5 | — | |
HCEDLZCUHOEHNH
|
9.7 | IC50 | 4 | — | |
HVAMCPMMTPHGBZ
|
9.7 | pIC50 | 5 | Yes | |
HVAMCPMMTPHGBZ
|
9.7 | IC50 | 12 | — |