Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KXFSTXOGNHZERD
|
8.0 | IC50 | 2 | — | |
UUJGSCUKYQKPHU
|
8.0 | IC50 | 2 | — | |
IHJPYWIDHOPLCK
|
7.9 | IC50 | 2 | — | |
QYGFMWMXWCEAQQ
|
7.9 | IC50 | 2 | — | |
FDNZNHRDINDRLM
|
7.9 | IC50 | 2 | — | |
WAOPBAUYEVWLHE
|
7.9 | IC50 | 2 | — | |
YSVQULSJUHTXBG
|
7.9 | IC50 | 2 | — | |
GCHWCYMGCVYULP
|
7.9 | Ki | 4 | — | |
JRVSFZKYQCETAH
|
7.9 | IC50 | 5 | — | |
KSKYRXFKNPXFGI
|
7.9 | IC50 | 6 | — | |
UBLXZGRGNPEZCR
|
7.9 | IC50 | 2 | — | |
VVLBZWIAAVKYHB
|
7.9 | IC50 | 2 | — | |
XGVDTEWKYAYOAZ
|
7.9 | IC50 | 2 | — | |
FKYWIAWIDUIWFG
|
7.9 | IC50 | 2 | — | |
CLRFYTGANQZOBS
|
7.9 | Ki | 41 | — | |
DQPYZHUAILXFJI
|
7.9 | Ki | 27 | — | |
LOCWELCIOZHZHE
|
7.9 | Ki | 11 | — | |
OWRXHGAFWZFFCW
|
7.9 | Ki | 113 | — | |
WTLKHNCRMWMEPP
|
7.9 | IC50 | 2 | — | |
BVZFHBJXEPPCEX
|
7.9 | IC50 | 2 | — | |
DVRUQNLSZFAFOD
|
7.9 | IC50 | 2 | — | |
FXVIJUPKVPPUNX
|
7.9 | IC50 | 2 | — | |
JQEVJBGJLODSRH
|
7.9 | IC50 | 2 | — | |
QKKGSTFAKMXWFE
|
7.9 | IC50 | 3 | — | |
RCNSYAHCVQPUFD
|
7.9 | IC50 | 2 | — | |
RINUIXSHMABIND
|
7.9 | IC50 | 2 | — | |
SAWFCMBRIBWGDW
|
7.9 | IC50 | 2 | — | |
UGHABJRZQKZAHP
|
7.9 | IC50 | 6 | — | |
VBRGZHZCCDMLQY
|
7.9 | IC50 | 2 | — | |
ACSFOKQSDKYSPD
|
7.9 | IC50 | 2 | — | |
FCAFTJDYTVBVRW
|
7.9 | IC50 | 2 | — | |
APPRZRMVUBRYNF
|
7.9 | IC50 | 2 | — | |
BFSUUCMQXWZDOQ
|
7.9 | Ki | 2 | — | |
PPHSCZQMXMHEGU
|
7.9 | IC50 | 2 | — | |
RLIFPWWQKDVDLP
|
7.9 | IC50 | 2 | — | |
DXSRSGFNZLPAGW
|
7.8 | IC50 | 2 | — | |
KGOAUGHDPHDYBB
|
7.8 | IC50 | 2 | — | |
MHFWDTZIDHQBTC
|
7.8 | IC50 | 2 | — | |
OFDBLIAMQPCXKD
|
7.8 | Ki | 3 | — | |
OLIIUAHHAZEXEX
|
7.8 | IC50 | 3 | — | |
PFOOXZQINUSRCD
|
7.8 | IC50 | 6 | — | |
RPCURYQRJHATFZ
|
7.8 | IC50 | 2 | — | |
SAGGCAPQVJYEGE
|
7.8 | IC50 | 3 | — | |
VRZUDQNRTCEYKK
|
7.8 | IC50 | 2 | — | |
WVGDUQVQWLHVEA
|
7.8 | IC50 | 4 | — | |
AOMUHYVRSKACNP
|
7.8 | Ki | 3 | — | |
CVOQFIXUFCBSSC
|
7.8 | IC50 | 2 | — | |
UGYAZGXSMRGKRD
|
7.8 | IC50 | 3 | — | |
YKCPIOFQNXOLHH
|
7.8 | IC50 | 2 | — | |
FTUKZMZRGJAOKF
|
7.8 | IC50 | 2 | — |