Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YWTBGJGMTBHQTM
|
8.1 | Ki | 65 | — | |
BFSFWCMZFSXSOK
|
8.1 | Ki | 4 | — | |
GNPISLOHLRSZHY
|
8.1 | IC50 | 4 | — | |
FRWXJFJBJPGDJM
|
8.1 | IC50 | 2 | — | |
PASSAYPELLITCR
|
8.1 | IC50 | 2 | — | |
SEJXTFIDDFUTMH
|
8.1 | IC50 | 2 | — | |
SEPHKODFYBTYDV
|
8.1 | IC50 | 2 | — | |
CXWOMMUYWIPPCD
|
8.1 | IC50 | 2 | — | |
FJUYJNSUOZJBSU
|
8.1 | IC50 | 2 | — | |
KQGQDDJOYKZFPV
|
8.1 | IC50 | 8 | — | |
DBKFQGAJZUOGMZ
|
8.1 | IC50 | 2 | — | |
GDVRVPIXWXOKQO
|
8.1 | IC50 | 10 | — | |
HUXWDCVBFRJBIH
|
8.1 | Ki | 3 | — | |
IFYDROJSRZHNOS
|
8.1 | IC50 | 5 | — | |
JHZUXOVQEXDSPY
|
8.1 | IC50 | 2 | — | |
JLWTUPLIJAHTKE
|
8.1 | IC50 | 3 | — | |
XJVGQDMDOVIHME
|
8.1 | IC50 | 6 | — | |
YUXHVLCKVCBVIZ
|
8.1 | IC50 | 7 | — | |
CYPOEEIUKVOVGO
|
8.0 | IC50 | 2 | — | |
BZVQOZIIWUBEPH
|
8.0 | Ki | 3 | — | |
OYUCUEABSDSADC
|
8.0 | Ki | 3 | — | |
PZAYZTYHHVPMFG
|
8.0 | IC50 | 2 | — | |
BNSKTIACOBJLNV
|
8.0 | IC50 | 2 | — | |
CNQICKRUYCWBEH
|
8.0 | IC50 | 2 | — | |
DVTKMLJDBJSXHF
|
8.0 | IC50 | 2 | — | |
FDFPXMUSBROKPG
|
8.0 | IC50 | 2 | — | |
GFWDPXHTWJXOEI
|
8.0 | IC50 | 3 | — | |
IMZIJLMIOSQRGE
|
8.0 | IC50 | 2 | — | |
IVWXFGRLNHCKNV
|
8.0 | Ki | 2 | — | |
KRZMKLFPGBUXGH
|
8.0 | IC50 | 3 | — | |
NVDYRDZHCINQQB
|
8.0 | IC50 | 3 | — | |
NVHVDZKSZLWUNH
|
8.0 | IC50 | 5 | — | |
OADCLEGMNAVWGX
|
8.0 | IC50 | 2 | — | |
PRIKHRTWFXDNDC
|
8.0 | Ki | 3 | — | |
QWQSSMVCJVZYQX
|
8.0 | Ki | 3 | — | |
UOMBBRLBZANHQY
|
8.0 | IC50 | 2 | — | |
ZAMBLNKLSSPUQI
|
8.0 | IC50 | 2 | — | |
SDWJCHAEHSUYNZ
|
8.0 | IC50 | 2 | — | |
ZKQKBOWBNMYREE
|
8.0 | IC50 | 2 | — | |
BTNHOAWDPXMJLS
|
8.0 | Ki | 4 | — | |
AFRRRQARLYDLTJ
|
8.0 | IC50 | 2 | — | |
BLMBNKDQXGINRE
|
8.0 | IC50 | 3 | — | |
CRFSDZNCOBDRQG
|
8.0 | IC50 | 2 | — | |
HSMAACWXVBSPJQ
|
8.0 | IC50 | 2 | — | |
JQCWNEXLKSGUJQ
|
8.0 | IC50 | 3 | — | |
NKWSAYGUIMPROA
|
8.0 | IC50 | 10 | — | |
QAGMCUQKCSBMNN
|
8.0 | IC50 | 2 | — | |
VLGGZKWVODZVTH
|
8.0 | IC50 | 2 | — | |
YOXPJLZIOXCBGO
|
8.0 | IC50 | 4 | — | |
ICBYDYURLUCFTP
|
8.0 | IC50 | 2 | — |