Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
BGYVWFZMYBWCNY
|
8.4 | Ki | 30 | — | |
GJOXRIYWDHESDF
|
8.4 | Ki | 27 | — | |
KAWWWOFUKPBPQJ
|
8.4 | IC50 | 2 | — | |
LJQLCPYRTIQYAH
|
8.4 | IC50 | 2 | — | |
MTJPSOHLRSAFBG
|
8.4 | IC50 | 3 | — | |
NWMPVMMGSHXANZ
|
8.4 | Ki | 58 | — | |
XYZNKCSDQRKAFR
|
8.4 | Ki | 53 | — | |
ZCWWQXJFVPYXDZ
|
8.4 | IC50 | 2 | — | |
ZUJRYKFJARKTIO
|
8.4 | IC50 | 3 | — | |
IMUQMJFWSHDHRX
|
8.4 | IC50 | 2 | — | |
JHSCGTOSSCUERL
|
8.4 | IC50 | 3 | — | |
QXUHEZFLKIFWOJ
|
8.4 | IC50 | 2 | — | |
DCKFOWBHBAGPRR
|
8.4 | IC50 | 2 | — | |
AJFYMCKXLCRURF
|
8.4 | IC50 | 5 | — | |
FQYIMRXBBCWILN
|
8.4 | IC50 | 2 | — | |
PGYLYUYINPOJLP
|
8.4 | IC50 | 2 | — | |
KTVRJTYYMLXASQ
|
8.3 | IC50 | 2 | — | |
MKOLBFDKJXCKJK
|
8.3 | IC50 | 2 | — | |
SBMIMRGGSPVOAG
|
8.3 | IC50 | 2 | — | |
ZFDYBUAPZQQBIX
|
8.3 | IC50 | 2 | — | |
AZLYARWHEXPDEW
|
8.3 | IC50 | 2 | — | |
HMBSHDURLZEMQP
|
8.3 | IC50 | 2 | — | |
ACSYKUPGCXYRRO
|
8.3 | Ki | 26 | — | |
BTFXRESVGZYZQN
|
8.3 | IC50 | 2 | — | |
GEWPHZNCWUIEEN
|
8.3 | IC50 | 3 | — | |
HRCKLYFDWWYCLS
|
8.3 | Ki | 2 | — | |
HRCKLYFDWWYCLS
|
8.3 | Ki | 2 | — | |
MLGGUGPIWDHBAI
|
8.3 | Ki | 33 | — | |
NSQDEFOCIHUFJM
|
8.3 | IC50 | 4 | — | |
OKUPZBPYLVKVSU
|
8.3 | Ki | 3 | — | |
PDSGDBHQLRAVID
|
8.3 | IC50 | 2 | — | |
PHWHNHYZZNJPLB
|
8.3 | IC50 | 3 | — | |
QOPVBHZKTCLPOW
|
8.3 | IC50 | 2 | — | |
RIIYKHQJSKRYKG
|
8.3 | IC50 | 3 | — | |
SIFDVGOSDLKPGX
|
8.3 | IC50 | 2 | — | |
SLKCVFPEQGHNSI
|
8.3 | Ki | 29 | — | |
XPHWIERLJBFPFV
|
8.3 | Ki | 69 | — | |
HCIIPWGEJOAVRZ
|
8.3 | IC50 | 2 | — | |
WSXKSMSBOLIXMK
|
8.3 | IC50 | 2 | — | |
ANGDJJFQAIUXQR
|
8.3 | IC50 | 2 | — | |
MMLWXRJMBOZWCU
|
8.3 | IC50 | 2 | — | |
RSJLKPAADCXPOZ
|
8.3 | IC50 | 2 | — | |
UDWJOFBRPYNJOD
|
8.3 | IC50 | 2 | — | |
WNFAWYDESPZZIJ
|
8.3 | IC50 | 2 | — | |
PHWHNHYZZNJPLB
|
8.2 | IC50 | 6 | Yes | |
ZQYPIHNDLBYJOW
|
8.2 | IC50 | 2 | — | |
ZKQKBOWBNMYREE
|
8.2 | IC50 | 2 | — | |
AWDORCFLUJZUQS
|
8.2 | Ki | 7 | — | |
FCVSCBFMVWNZGA
|
8.2 | IC50 | 2 | — | |
FHISAROGPSYNME
|
8.2 | Ki | 10 | — |