Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IYOZTVGMEWJPKR
|
8.7 | Ki | 10 | — | |
KEBMSGAJMPWLNS
|
8.7 | IC50 | 7 | Yes | |
MUVYYVZAJFICKR
|
8.7 | IC50 | 2 | — | |
VDYRZXYYQMMFJW
|
8.7 | Ki | 2 | — | |
GKKIGWFSHHJSMM
|
8.7 | IC50 | 2 | — | |
YSCICSHOCDXCAS
|
8.7 | IC50 | 2 | — | |
HIVOASQRESOTMJ
|
8.7 | IC50 | 2 | — | |
FJEFZEKCTMBIHV
|
8.7 | IC50 | 2 | — | |
LFJFWJSDSCDXIT
|
8.7 | IC50 | 2 | — | |
MXUZFINOYNQLNI
|
8.7 | IC50 | 2 | — | |
BCJSNQZZTLHTAJ
|
8.6 | IC50 | 2 | — | |
JWVWCAKTWBMEPU
|
8.6 | IC50 | 2 | — | |
OVQFXLFWQAYHOI
|
8.6 | IC50 | 2 | — | |
UANOWIUKWGKWOC
|
8.6 | IC50 | 2 | — | |
HOYRWTWZUFFACV
|
8.6 | Ki | 28 | — | |
JRVSFZKYQCETAH
|
8.6 | Ki | 19 | — | |
MTZPPYMBIBCZBH
|
8.6 | IC50 | 2 | — | |
OMQBPULZTUQWCQ
|
8.6 | IC50 | 2 | — | |
JDIAOFCAAPMAGG
|
8.6 | Ki | 4 | — | |
STUSYRQGNZOVSJ
|
8.6 | IC50 | 2 | — | |
RKMCHMVWGYLCNL
|
8.5 | IC50 | 2 | — | |
FIFFDYNJQGROBO
|
8.5 | IC50 | 5 | — | |
GRUQPKMQXSFMIX
|
8.5 | IC50 | 2 | — | |
MBEYXNMHPBPYSU
|
8.5 | IC50 | 3 | — | |
QTSWVSMSXVPNMM
|
8.5 | IC50 | 2 | — | |
YAIFMBBJHJRLEF
|
8.5 | IC50 | 2 | — | |
ZGCMTTQGRJYCEP
|
8.5 | IC50 | 2 | — | |
CEUGVFZOIFRDQZ
|
8.5 | IC50 | 2 | — | |
MKSLDODSQFIWOS
|
8.5 | IC50 | 2 | — | |
WHGWETKOANDIKB
|
8.5 | IC50 | 2 | — | |
HJTMKXREKMTLHV
|
8.5 | IC50 | 2 | — | |
URNZTLZSAVLTIZ
|
8.5 | Ki | 26 | — | |
VXYDJXMHISGSDA
|
8.5 | Ki | 59 | — | |
WHGWETKOANDIKB
|
8.5 | IC50 | 2 | — | |
LWBVQGQTGHIORB
|
8.5 | IC50 | 2 | — | |
MBFDUQROVSLSPJ
|
8.5 | IC50 | 2 | — | |
WDKLHPSKXZBSDU
|
8.5 | IC50 | 2 | — | |
WHVMMFVGEVMVIT
|
8.5 | IC50 | 2 | — | |
NRSGWEVTVGZDFC
|
8.5 | IC50 | 50 | — | |
CPEWUKOGQOXNMY
|
8.5 | IC50 | 2 | — | |
ICHFSXPUXZFBPH
|
8.5 | IC50 | 2 | — | |
ROFMCPHQNWGXGE
|
8.5 | IC50 | 3 | — | |
WPXXNWXNNZASGI
|
8.5 | IC50 | 2 | — | |
HIUHVDROHDSKTC
|
8.5 | Ki | 20 | — | |
OMVMGDVRMSCTFN
|
8.5 | IC50 | 3 | — | |
URCYWTVGSLLYNQ
|
8.4 | IC50 | 2 | — | |
LPIJLTWKGVCMHH
|
8.4 | Ki | 2 | — | |
SUAFXIYFPRWWOY
|
8.4 | IC50 | 2 | — | |
MAUISDMNPMEWQF
|
8.4 | IC50 | 2 | — | |
AOFGEEDOUASHKV
|
8.4 | Ki | 4 | — |