Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QRVGBTGBMIUBQJ
|
7.1 | IC50 | 2 | — | |
UYRZRWDVJAODCA
|
7.1 | IC50 | 2 | — | |
VWVYILCFSYNJHF
|
7.1 | Ki | 49 | — | |
XSDJOIOVIMPMHD
|
7.1 | Ki | 44 | — | |
ZHKSGKFGSOLMFL
|
7.1 | Ki | 2 | — | |
GRUQPKMQXSFMIX
|
7.1 | IC50 | 2 | — | |
VPJJIOPOZCPBMR
|
7.1 | IC50 | 2 | — | |
BOAXHGZLIGFEMG
|
7.1 | IC50 | 2 | — | |
IJASYRWFAWXBTH
|
7.1 | IC50 | 2 | — | |
MIONXARKYZYLSX
|
7.1 | Ki | 4 | — | |
QNIZYMHQGXFAMH
|
7.1 | IC50 | 2 | — | |
XVWAHNBWATXACB
|
7.1 | IC50 | 2 | — | |
YJQKIQOVJOGHMP
|
7.1 | IC50 | 2 | — | |
GDKARAKSWPBMFG
|
7.1 | IC50 | 2 | — | |
HQXFLJXIZJFNTB
|
7.1 | IC50 | 2 | — | |
JDIAOFCAAPMAGG
|
7.1 | Ki | 4 | — | |
KKSLZAWDUQRHLJ
|
7.1 | Ki | 2 | — | |
NZNKOTVUZKHUSO
|
7.1 | Ki | 3 | — | |
OSDWJAUTLIVEOA
|
7.1 | IC50 | 2 | — | |
QANOXOWLUOTIAC
|
7.1 | IC50 | 3 | — | |
UQCQILGVCWTQMD
|
7.1 | IC50 | 2 | — | |
HKDHMLZFVTUIRI
|
7.1 | IC50 | 2 | — | |
OUOPQLSJLBGMFE
|
7.1 | IC50 | 2 | — | |
XBZXHNZMLDBPGC
|
7.1 | IC50 | 2 | — | |
FRGKMOOHXXLJSE
|
7.0 | Ki | 2 | — | |
LBVAPUMJWBSQAC
|
7.0 | IC50 | 2 | — | |
LHJWDAABBSKSEQ
|
7.0 | IC50 | 3 | — | |
PTROMZWPUXNMAK
|
7.0 | IC50 | 2 | — | |
TZGDXUFTIVMJQY
|
7.0 | IC50 | 2 | — | |
UFRZVVLEFMQDSZ
|
7.0 | IC50 | 2 | — | |
CUJPUWSIKWTBRS
|
7.0 | Ki | 3 | — | |
CZYVRBPRTGDQLG
|
7.0 | IC50 | 2 | — | |
GOPDRFODUBCWMB
|
7.0 | Ki | 2 | — | |
QUEIBWXZNMHZJD
|
7.0 | Ki | 4 | — | |
AHOPLZOKZVFDJT
|
7.0 | IC50 | 2 | — | |
DYOILCGEGQTBTJ
|
7.0 | IC50 | 2 | — | |
FATSBSNRASYTNE
|
7.0 | IC50 | 2 | — | |
GASKYZOWZMIJOP
|
7.0 | Ki | 4 | — | |
LHCKGRAGUJSIPB
|
7.0 | Ki | 3 | — | |
BCWPQKADGZOWMA
|
7.0 | IC50 | 3 | — | |
GZWZWHDONMXYLT
|
7.0 | IC50 | 2 | — | |
LXQGBVWOYPFPJU
|
7.0 | IC50 | 2 | — | |
PNGGDJQCOFAGPU
|
7.0 | IC50 | 2 | — | |
VAMDLIMJLAPZGX
|
7.0 | IC50 | 2 | — | |
VPEQKGXRQZTIES
|
7.0 | IC50 | 6 | — | |
WAWIIKAKESUSCT
|
7.0 | IC50 | 2 | — | |
ZRTWUBWXIGHVET
|
7.0 | IC50 | 2 | — | |
BSBBIWMXRBLRGQ
|
7.0 | IC50 | 2 | — | |
GRFYVFBPFKGUQO
|
7.0 | Ki | 2 | — | |
IGTNWPHKEMOAGM
|
7.0 | IC50 | 2 | — |