Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HEGUJMRUCIWLNE
|
7.2 | Ki | 4 | — | |
HHGYNBXPZXZDBW
|
7.2 | Ki | 4 | — | |
KFCCRAZFDCBPNZ
|
7.2 | IC50 | 2 | — | |
MGSFSBWPBXVAEQ
|
7.2 | IC50 | 2 | — | |
NXLSASWJJYWMJP
|
7.2 | IC50 | 2 | — | |
WVKCMVMISLIFTD
|
7.2 | Ki | 4 | — | |
YLRZEPPAUZLMKR
|
7.2 | IC50 | 7 | — | |
JNVSJVSIHCPPTE
|
7.2 | IC50 | 2 | — | |
MGLIYKZFLDTAMW
|
7.2 | Kd | 2 | — | |
OTQBWQLVWMNWBE
|
7.2 | IC50 | 2 | — | |
PWPNYABQEOGNNC
|
7.2 | IC50 | 4 | — | |
VWRPPJRHTCKDIP
|
7.2 | IC50 | 2 | — | |
AQBIAGJFJKMCNG
|
7.2 | Ki | 4 | — | |
BLJRGKGBUVZYAP
|
7.2 | IC50 | 2 | — | |
GCIKTBNRNWBQHT
|
7.2 | Ki | 2 | — | |
ROXVNVHBPSJCEM
|
7.2 | IC50 | 2 | — | |
SHZBLRCXYAENEO
|
7.2 | IC50 | 2 | — | |
BKQFBAILJJESBH
|
7.1 | IC50 | 2 | — | |
PGAUIFVQAJTKKJ
|
7.1 | IC50 | 2 | — | |
RTCFKJVSDGLJAM
|
7.1 | Ki | 3 | — | |
UGPDNKHGAAKZIR
|
7.1 | IC50 | 2 | — | |
USXYFWZRBRCQLR
|
7.1 | IC50 | 6 | — | |
VBBARCMTJPDGFK
|
7.1 | IC50 | 2 | — | |
XUGHJQRTNYRFEP
|
7.1 | IC50 | 2 | — | |
JQPFBPKZRBMCCY
|
7.1 | IC50 | 2 | — | |
KQDJZQWFJGSGBV
|
7.1 | Ki | 3 | — | |
LNOMUGHAHOAATL
|
7.1 | IC50 | 2 | — | |
XJSRTZCKTBCQLJ
|
7.1 | Ki | 3 | — | |
DWFFOTBUFHRBSA
|
7.1 | IC50 | 2 | — | |
JBLPUDJLELBRHC
|
7.1 | IC50 | 9 | — | |
MHCQGPSBRNOVHU
|
7.1 | IC50 | 2 | — | |
OQGZWUQINVEKPB
|
7.1 | IC50 | 2 | — | |
VQRBDWKISUWWCW
|
7.1 | IC50 | 2 | — | |
ZUORJMYVIBRGPQ
|
7.1 | IC50 | 2 | — | |
HEAIGWIZTYAQTC
|
7.1 | IC50 | 2 | — | |
JJMSDZDJAYEOSY
|
7.1 | Ki | 2 | — | |
WTLKHNCRMWMEPP
|
7.1 | IC50 | 2 | — | |
XDZHGRSCNCMGSV
|
7.1 | IC50 | 2 | — | |
BBZSEXSOPOXLIQ
|
7.1 | Ki | 8 | — | |
BOJODXOBEKPFNV
|
7.1 | Ki | 2 | — | |
FUSGHFKTWQRWPV
|
7.1 | Ki | 4 | — | |
FXQWJULRETZHHW
|
7.1 | Ki | 14 | — | |
FYRQDEVTRMEZHR
|
7.1 | Ki | 7 | — | |
KCKXYZOBGBJZEG
|
7.1 | Ki | 36 | — | |
KCQPEINYMIEKJO
|
7.1 | IC50 | 2 | — | |
LIJVDSICFNWJFS
|
7.1 | IC50 | 2 | — | |
LRZYYIZFBXFSJB
|
7.1 | Ki | 69 | — | |
NEWAULHLLUCDPD
|
7.1 | Ki | 27 | — | |
NGDNKYRUKIPCLK
|
7.1 | Ki | 12 | — | |
PJSBFZAYJQMORO
|
7.1 | Ki | 11 | — |