Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
DGPJCEDEJQDQFA
|
7.4 | Ki | 3 | — | |
MCRBBYMYLBISCB
|
7.4 | IC50 | 2 | — | |
RDSJJFGKRCBYRH
|
7.4 | IC50 | 4 | — | |
RJXSCRRYUBZADY
|
7.4 | IC50 | 2 | — | |
RKGXRJNCSPXVMJ
|
7.4 | IC50 | 2 | — | |
SKYALJGMRAGHEN
|
7.4 | IC50 | 2 | — | |
TZXXWAVRQLLEQF
|
7.4 | IC50 | 2 | — | |
DASFSPDIWCMVRW
|
7.4 | Ki | 21 | — | |
GRMVBDUZCLNCGD
|
7.4 | IC50 | 3 | — | |
HMHOSGROTWHBMJ
|
7.4 | IC50 | 2 | — | |
LACOMQAWPSFXQC
|
7.4 | Ki | 27 | — | |
MWPKVVFLQRKJCI
|
7.4 | IC50 | 3 | — | |
RFBPWKMQWSIPEO
|
7.4 | Ki | 28 | — | |
RQKKDDPVAKBRAI
|
7.4 | IC50 | 2 | — | |
UELSMLDRSQFVHG
|
7.4 | Ki | 4 | — | |
XMFUGSRATNLPRM
|
7.4 | Ki | 19 | — | |
YGEACCLUBSGMMJ
|
7.4 | Ki | 16 | — | |
ZOJWMHJRZRKSRN
|
7.4 | Ki | 2 | — | |
ZOJWMHJRZRKSRN
|
7.4 | Ki | 2 | — | |
ZOYHKPSDAMEYBR
|
7.4 | IC50 | 2 | — | |
ZRTWUBWXIGHVET
|
7.4 | Ki | 10 | — | |
KEFQUXNLAYXGGS
|
7.4 | IC50 | 2 | — | |
LLVCSPYXPUYDCE
|
7.4 | Ki | 3 | — | |
LXQGBVWOYPFPJU
|
7.4 | IC50 | 2 | — | |
XSLFUSVQDXPOPE
|
7.4 | IC50 | 2 | — | |
ZZOUOZQSRJYAMC
|
7.4 | IC50 | 2 | — | |
BMMXFLCCJJRAMC
|
7.4 | Ki | 3 | — | |
OORBXCUUHIIWJV
|
7.4 | IC50 | 2 | — | |
PNNANOOTMGLECQ
|
7.4 | IC50 | 2 | — | |
BXUCQKDKSJSLDL
|
7.4 | IC50 | 2 | — | |
DPJRGWXPXGPHGL
|
7.4 | IC50 | 2 | — | |
DXBVMSLBLNVYPE
|
7.4 | IC50 | 4 | — | |
MQYQXIHEKOMMHJ
|
7.4 | IC50 | 2 | — | |
SBMZASWPEBFVCG
|
7.4 | IC50 | 2 | — | |
ZMDKREPZDCSSGY
|
7.4 | IC50 | 2 | — | |
ADGQNANENRDMEA
|
7.4 | Ki | 4 | — | |
GJJMACISLUAOSI
|
7.4 | Ki | 3 | — | |
LBESRPHKXLREQJ
|
7.4 | IC50 | 2 | — | |
SPMLNRHNYBYMMZ
|
7.4 | IC50 | 2 | — | |
UZXCLKOZEMNTRB
|
7.4 | Ki | 3 | — | |
VHZNRUKXHPDXMR
|
7.4 | Ki | 4 | — | |
XLWPIULKZPLIRA
|
7.4 | IC50 | 5 | — | |
ZPRHGJOOCBVZCP
|
7.4 | IC50 | 7 | — | |
HRELGTDDFADJJJ
|
7.3 | IC50 | 2 | — | |
JJTVMBJRPZIZDA
|
7.3 | IC50 | 4 | — | |
JQHQSWUFSHQDHF
|
7.3 | IC50 | 2 | — | |
TUMVBSIBURICOB
|
7.3 | IC50 | 2 | — | |
ZARZTVDSAHZYSP
|
7.3 | IC50 | 2 | — | |
FYKKNMQWIMTCOO
|
7.3 | IC50 | 2 | — | |
RHLKDYGYAZQPER
|
7.3 | IC50 | 2 | — |