Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MPCRMOBUNIRDSJ
|
7.5 | IC50 | 2 | — | |
SIKMVWPMDNIKAY
|
7.5 | IC50 | 2 | — | |
UHTJASDMENLSNM
|
7.5 | IC50 | 2 | — | |
BACMEOIVTBXRAB
|
7.5 | Ki | 3 | — | |
CJGPSZKKXISGIT
|
7.5 | IC50 | 2 | — | |
GUOHCRYZNLVGBD
|
7.5 | IC50 | 2 | — | |
HEESYZLXEJDLJI
|
7.5 | IC50 | 4 | — | |
JQHSLDZAVPJKFZ
|
7.5 | Ki | 4 | — | |
OGPFJRNUCSCJQP
|
7.5 | IC50 | 2 | — | |
OXWFDKJEHLGZPM
|
7.5 | IC50 | 2 | — | |
YAKZDTJRKIBSBA
|
7.5 | Ki | 2 | — | |
ZSRGQQNNHDFZKU
|
7.5 | IC50 | 2 | — | |
AWDORCFLUJZUQS
|
7.5 | IC50 | 22 | — | |
FECLECZQPSAYTM
|
7.5 | IC50 | 7 | — | |
JFOPDXJGAOLMTK
|
7.5 | IC50 | 2 | — | |
LWMGXEAOAQXWQY
|
7.5 | IC50 | 2 | — | |
NLCAMNKZRYBJFY
|
7.5 | Ki | 2 | — | |
NXSJMRCTGYTSTK
|
7.5 | Kd | 200 | — | |
ODUYVHAFJTXMAF
|
7.5 | Ki | 3 | — | |
PDOWPLWTKJLFMU
|
7.5 | IC50 | 2 | — | |
SMJQHCKLPYGUNB
|
7.5 | IC50 | 3 | — | |
ZTDZUGXYUUIFQW
|
7.5 | IC50 | 2 | — | |
CIXVBMOGRAAGGW
|
7.5 | IC50 | 2 | — | |
GLXJGZLTPLOTJM
|
7.5 | IC50 | 4 | — | |
MTZPPYMBIBCZBH
|
7.5 | IC50 | 2 | — | |
QTCNZFUXSFUHGU
|
7.5 | IC50 | 2 | — | |
XZOMFGUPUHMZFT
|
7.5 | IC50 | 2 | — | |
BJLOBSMGZUMYOP
|
7.4 | IC50 | 8 | — | |
FRPJSZRAPBBGTE
|
7.4 | IC50 | 2 | — | |
GLHLUQHSURPDFN
|
7.4 | IC50 | 3 | — | |
GMLKJSOWCKBKLX
|
7.4 | IC50 | 5 | — | |
PWWJBQFUGNBNDJ
|
7.4 | IC50 | 2 | — | |
TXMBFHDPFFYWML
|
7.4 | IC50 | 2 | — | |
UVDICPSQYBDYJS
|
7.4 | IC50 | 2 | — | |
FCNATYJSJSHBTN
|
7.4 | IC50 | 3 | — | |
FWVPDHPTJUHLCW
|
7.4 | IC50 | 2 | — | |
LQRGVYJVTGFQPC
|
7.4 | IC50 | 2 | — | |
NTVGZILGUNKNME
|
7.4 | IC50 | 2 | — | |
QCMDWRLNDWXISF
|
7.4 | IC50 | 2 | — | |
QQWUGDVOUVUTOY
|
7.4 | Kd | 231 | Yes | |
QTMFCQXLQBJZQU
|
7.4 | IC50 | 4 | — | |
UARARIOSCGMOEN
|
7.4 | IC50 | 2 | — | |
VUKPYAYVXNDTIK
|
7.4 | IC50 | 2 | — | |
YJMNZRBIDTUOAU
|
7.4 | IC50 | 2 | — | |
BKOIAFICAZVOHM
|
7.4 | IC50 | 2 | — | |
CXSQMXRQOZZFLD
|
7.4 | IC50 | 18 | — | |
HPUIONZOLCECJV
|
7.4 | IC50 | 2 | — | |
MEGGDKYEQSCVTG
|
7.4 | IC50 | 2 | — | |
VLFYWLXMVQEGMJ
|
7.4 | Ki | 3 | — | |
CAVXYZKAHQCDJF
|
7.4 | IC50 | 2 | — |