Target Details
| UniProt AC | Q13464 |
|---|---|
| Gene Symbol | ROCK1 |
| Protein Name | Rho-associated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF25346 (PH_MRCK) PF00069 (Pkinase) PF08912 (Rho_Binding) |
Summary
- Multi-target molecules 1,614
- Clinical molecules 34
- Avg pChEMBL 7.13
KEGG Pathways (22)
- Adherens junction
- Axon guidance
- Cadherin signaling
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- MicroRNAs in cancer
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Shigellosis
- Sphingolipid signaling pathway
- TGF-beta signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
Active Molecules (1,614)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
BKKKAMZWSRIKDA
|
9.7 | IC50 | 2 | — | |
LTXBFJFJUIJOQE
|
9.7 | Ki | 3 | — | |
QFPRZTWQNKAKTH
|
9.7 | IC50 | 2 | — | |
DPGQPPYMTLBAIO
|
9.6 | IC50 | 2 | — | |
YGZVCRLWTNQONT
|
9.4 | IC50 | 2 | — | |
ZTBJDQDNHPHYGS
|
9.4 | IC50 | 7 | — | |
WPOIOKJTVWXYEA
|
9.4 | IC50 | 2 | — | |
ZASVASVCLDFZGK
|
9.3 | Ki | 2 | — | |
XEXZHTMEICBSBN
|
9.3 | IC50 | 2 | — | |
ZUJRYKFJARKTIO
|
9.3 | IC50 | 3 | — | |
YISMQBFJYDFMAL
|
9.2 | IC50 | 46 | — | |
HKSZLNNOFSGOKW
|
9.2 | IC50 | 408 | — | |
TUQZDIZIVRTIGP
|
9.2 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
9.1 | Ki | 118 | — | |
JUCBZNHHQKCEMY
|
9.1 | IC50 | 2 | — | |
KQDDDWVLLDDHOF
|
9.1 | IC50 | 2 | — | |
PHWHNHYZZNJPLB
|
9.1 | Ki | 16 | — | |
XZZUBMJMGJRIKY
|
9.1 | Ki | 4 | — | |
OAMYGUPZJRNSAO
|
9.1 | IC50 | 2 | — | |
IHPZTIFVUUEGSN
|
9.0 | IC50 | 2 | — | |
SJHKIJFJOUJEAT
|
9.0 | IC50 | 2 | — | |
GKCYBFUIFHJFSO
|
8.9 | IC50 | 2 | — | |
GRFHEJWFORZSDZ
|
8.9 | IC50 | 2 | — | |
HWVIELIZINHJJY
|
8.9 | IC50 | 2 | — | |
GPERPWCLYBHCRW
|
8.9 | IC50 | 2 | — | |
GSOQMEARYDGDSU
|
8.9 | IC50 | 2 | — | |
MTZPPYMBIBCZBH
|
8.9 | IC50 | 2 | — | |
SJLQDZDKTVBBLP
|
8.9 | Ki | 9 | — | |
WDARYLSSWBWVCU
|
8.9 | Ki | 49 | — | |
XUFLBSMTYMFOQH
|
8.9 | Ki | 43 | — | |
PABLVBARXHFRFL
|
8.9 | Kd | 5 | — | |
WTZMCUOBQPTERK
|
8.9 | IC50 | 2 | — | |
RRARUIHCCITXRN
|
8.8 | IC50 | 2 | — | |
JKLZPEFCFKLVKA
|
8.8 | IC50 | 2 | — | |
AEFIGQFODUVLFR
|
8.8 | IC50 | 2 | — | |
CYRVCGFQHLNZFS
|
8.8 | Ki | 3 | — | |
IMFURASUGLYMJT
|
8.8 | IC50 | 3 | — | |
MCQBNMPALTYSES
|
8.8 | IC50 | 3 | — | |
REFWKLXNGKEUSQ
|
8.8 | IC50 | 2 | — | |
HVEZIMSTJWKUGP
|
8.8 | IC50 | 2 | — | |
SIENFBFCGKUHOH
|
8.8 | IC50 | 2 | — | |
YOVNFNXUCOWYSG
|
8.8 | IC50 | 33 | Yes | |
CKUIXZUZIPIFQX
|
8.8 | IC50 | 2 | — | |
XESDIZSUBGMYNC
|
8.8 | IC50 | 2 | — | |
ZEVPNNBHHMHIGE
|
8.8 | IC50 | 2 | — | |
FKLDWZRWKZTOCJ
|
8.7 | IC50 | 7 | — | |
SGJZTWNMDXDAKV
|
8.7 | IC50 | 2 | — | |
VWFVTEZXZVPVIK
|
8.7 | Ki | 3 | — | |
ABADVZLOYZQQIW
|
8.7 | IC50 | 2 | — | |
CJDWZZDGEKRVQD
|
8.7 | IC50 | 2 | — |