Target Details
| UniProt AC | Q13224 |
|---|---|
| Gene Symbol | GRIN2B |
| Protein Name | Glutamate receptor ionotropic, NMDA 2B |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01094 (ANF_receptor) PF00060 (Lig_chan) PF10613 (Lig_chan-Glu_bd) PF10565 (NMDAR2_C) |
Summary
- Multi-target molecules 1,823
- Clinical molecules 2
- Avg pChEMBL 7.16
KEGG Pathways (21)
- Alcoholism
- Alzheimer disease
- Amphetamine addiction
- Amyotrophic lateral sclerosis
- Calcium signaling pathway
- Circadian entrainment
- Cocaine addiction
- Dopaminergic synapse
- Glutamatergic synapse
- Huntington disease
- Long-term potentiation
- Neuroactive ligand signaling
- Neuroactive ligand-receptor interaction
- Nicotine addiction
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Rap1 signaling pathway
- Ras signaling pathway
- Spinocerebellar ataxia
- Systemic lupus erythematosus
- cAMP signaling pathway
Associated Diseases (2)
Active Molecules (1,823)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UHUIEJUQWSPSJU
|
7.4 | IC50 | 2 | — | |
UOOXJKOSONIHHK
|
7.4 | IC50 | 2 | — | |
XVKBTXGTFZBYCB
|
7.4 | IC50 | 2 | — | |
YQIJOWAODMSRBV
|
7.4 | IC50 | 2 | — | |
ACMVJUFVEAPEFM
|
7.4 | IC50 | 3 | — | |
CAOLWEYKTUSPPC
|
7.4 | IC50 | 7 | — | |
GRKTXLLGRRASAN
|
7.4 | IC50 | 3 | — | |
JIYGIBZQYHLRHY
|
7.4 | IC50 | 2 | — | |
KGHCBOGJKCPXLM
|
7.4 | IC50 | 2 | — | |
NWZZGFHHRXMAFZ
|
7.4 | IC50 | 2 | — | |
PACAOBGJGOLPHV
|
7.4 | IC50 | 2 | — | |
UJNMJERYEYGLSD
|
7.4 | IC50 | 2 | — | |
WKJNJMVKIZPRSV
|
7.4 | IC50 | 3 | — | |
ZODXHEFTTJWNPK
|
7.4 | IC50 | 3 | — | |
ZVGWHQFTALTBJE
|
7.4 | IC50 | 2 | — | |
DZYMQIQQTWEVNI
|
7.4 | IC50 | 2 | — | |
FDRRFKSBLXEOQB
|
7.4 | IC50 | 2 | — | |
JRWIPGDXKDTDTQ
|
7.4 | IC50 | 3 | — | |
KKLZGWQBNXJWGZ
|
7.4 | Ki | 4 | — | |
NOLSAUQWAYRWDL
|
7.4 | IC50 | 2 | — | |
NPZDNOIEXGVUNV
|
7.4 | IC50 | 3 | — | |
RQZPLXUUHUCNHE
|
7.4 | IC50 | 2 | — | |
SDPSTQUUXVTUDE
|
7.4 | IC50 | 7 | — | |
VBHCMVPALSQVLE
|
7.4 | IC50 | 2 | — | |
VMNZGYVAICSFKF
|
7.4 | IC50 | 3 | — | |
VOIICFPSPGURQN
|
7.4 | IC50 | 2 | — | |
YXENUGCAHCEBGR
|
7.4 | IC50 | 3 | — | |
ZUXFFTRMULBJMF
|
7.4 | IC50 | 3 | — | |
CYABDBONZXVBIX
|
7.4 | Ki | 2 | — | |
INTCEBHIEDIHMH
|
7.4 | IC50 | 2 | — | |
IOFXQVIETZNOBT
|
7.4 | IC50 | 2 | — | |
IRFYUKRBLYNANC
|
7.4 | IC50 | 2 | — | |
MIUJAGJHKIUJIO
|
7.4 | IC50 | 2 | — | |
RCUFTDBDPBZJIX
|
7.4 | IC50 | 3 | — | |
RWWJCPGNQCXYCF
|
7.4 | IC50 | 2 | — | |
UNWVKNIGRUANAZ
|
7.4 | IC50 | 3 | — | |
UTCTYCLIJAXLMT
|
7.4 | IC50 | 2 | — | |
VVESMMQELUCHPM
|
7.4 | IC50 | 3 | — | |
WYSXKRXUPILXPX
|
7.4 | IC50 | 2 | — | |
XASAWCRQWYULED
|
7.4 | IC50 | 3 | — | |
ARBHFERAFIBOCA
|
7.4 | IC50 | 2 | — | |
CAGIHHHPMFGUSU
|
7.4 | IC50 | 3 | — | |
CIOBCKYBUPDDOG
|
7.4 | IC50 | 2 | — | |
DBJDMGBZYSQFGL
|
7.4 | IC50 | 3 | — | |
QRBOGBACUMUXBQ
|
7.4 | IC50 | 3 | — | |
QZYQWQZBZLPROU
|
7.4 | IC50 | 3 | — | |
SOVDLHDBZOSKSK
|
7.4 | IC50 | 2 | — | |
WWNNHJQGPZMYAD
|
7.4 | IC50 | 2 | — | |
CPPDODNXZMDTEG
|
7.4 | IC50 | 2 | — | |
GVCSOLTVTCYQET
|
7.4 | IC50 | 2 | — |