Target Details
| UniProt AC | Q13224 |
|---|---|
| Gene Symbol | GRIN2B |
| Protein Name | Glutamate receptor ionotropic, NMDA 2B |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01094 (ANF_receptor) PF00060 (Lig_chan) PF10613 (Lig_chan-Glu_bd) PF10565 (NMDAR2_C) |
Summary
- Multi-target molecules 1,823
- Clinical molecules 2
- Avg pChEMBL 7.16
KEGG Pathways (21)
- Alcoholism
- Alzheimer disease
- Amphetamine addiction
- Amyotrophic lateral sclerosis
- Calcium signaling pathway
- Circadian entrainment
- Cocaine addiction
- Dopaminergic synapse
- Glutamatergic synapse
- Huntington disease
- Long-term potentiation
- Neuroactive ligand signaling
- Neuroactive ligand-receptor interaction
- Nicotine addiction
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Rap1 signaling pathway
- Ras signaling pathway
- Spinocerebellar ataxia
- Systemic lupus erythematosus
- cAMP signaling pathway
Associated Diseases (2)
Active Molecules (1,823)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SLAOSBOIGOOZSM
|
7.6 | Ki | 2 | — | |
SOSUBIQNRCZYSX
|
7.6 | IC50 | 3 | — | |
SPEQASRRMWSMMT
|
7.6 | IC50 | 3 | — | |
UKWUAWKCSVJIOD
|
7.6 | IC50 | 3 | — | |
WBKOUVTZNBJQEP
|
7.6 | IC50 | 3 | — | |
WGPIRIWUILWZNN
|
7.6 | IC50 | 3 | — | |
WZNXENIORLUKLM
|
7.6 | IC50 | 2 | — | |
YNNZXZMVRLYSIA
|
7.6 | IC50 | 3 | — | |
YVOZRAAZBKTCTA
|
7.6 | IC50 | 3 | — | |
CEVBVYRUQJAONP
|
7.6 | IC50 | 3 | — | |
DJZXKJVRASUECC
|
7.6 | IC50 | 3 | — | |
FLGHEYRTVBXLCT
|
7.6 | Ki | 2 | — | |
FWWLFKCNPNILNR
|
7.6 | IC50 | 3 | — | |
INOVNSMGJZPYFW
|
7.6 | IC50 | 2 | — | |
JWBLOPVZWHLMIE
|
7.6 | IC50 | 3 | — | |
LSNNQXKLIROZRO
|
7.6 | IC50 | 2 | — | |
LYKXCFZRVHBZJS
|
7.6 | IC50 | 7 | — | |
RLTQVLZBEQGICU
|
7.6 | IC50 | 2 | — | |
XRQLGIKMUXBVCL
|
7.6 | IC50 | 3 | — | |
ALZRKGLSAJHCNF
|
7.5 | IC50 | 3 | — | |
BRFSAHREHOBUQM
|
7.5 | IC50 | 2 | — | |
CNYLBHRHDRWZJA
|
7.5 | IC50 | 3 | — | |
DBXAGWCDLLONPH
|
7.5 | IC50 | 3 | — | |
FQBOIUBNVWYOTL
|
7.5 | IC50 | 2 | — | |
IMFSOXWKBGKOBT
|
7.5 | IC50 | 3 | — | |
JFJIXPGDUIKUBR
|
7.5 | IC50 | 2 | — | |
KAUOVPFBWVAPDU
|
7.5 | IC50 | 2 | — | |
OOVVHUHRQXOVBO
|
7.5 | IC50 | 2 | — | |
PTPHUJLNORVRIM
|
7.5 | IC50 | 2 | — | |
QRBOGBACUMUXBQ
|
7.5 | IC50 | 3 | — | |
SKNGTYNLYDWART
|
7.5 | IC50 | 2 | — | |
UDQKYUHUIJJCLM
|
7.5 | IC50 | 2 | — | |
UGSOVYIFNFDCSB
|
7.5 | IC50 | 2 | — | |
AGUAHSXVFZGKSM
|
7.5 | IC50 | 3 | — | |
BDIHREPQSBFVIU
|
7.5 | IC50 | 2 | — | |
BDKOCMNWFUTONP
|
7.5 | IC50 | 2 | — | |
CYJRVSOLVYLORV
|
7.5 | IC50 | 7 | — | |
DVJBOOXNZRWAJZ
|
7.5 | IC50 | 7 | — | |
DVMMXGXEXBVNQN
|
7.5 | IC50 | 2 | — | |
GFVHWHJSAPNZOO
|
7.5 | IC50 | 2 | — | |
MNQLZJMBMWVFPM
|
7.5 | IC50 | 3 | — | |
OVFADTJTEQNGRZ
|
7.5 | IC50 | 7 | — | |
PCDJNCAZXCSRDY
|
7.5 | IC50 | 2 | — | |
XBOYMQBHPFURQP
|
7.5 | IC50 | 2 | — | |
XDOXQXVOQXBFEG
|
7.5 | IC50 | 3 | — | |
YTMYFHIXMXDDNC
|
7.5 | IC50 | 2 | — | |
MTBDNFJHIYJQJD
|
7.5 | IC50 | 2 | — | |
BDABGOLMYNHHTR
|
7.5 | IC50 | 7 | — | |
BZHNUBPUQWUDLK
|
7.5 | IC50 | 2 | — | |
CNQACROBXLOAOB
|
7.5 | IC50 | 2 | — |