Target Details
| UniProt AC | Q13131 |
|---|---|
| Gene Symbol | PRKAA1 |
| Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16579 (AdenylateSensor) PF21147 (AMPK_alpha_AID) PF00069 (Pkinase) |
Summary
- Multi-target molecules 282
- Clinical molecules 27
- Avg pChEMBL 6.8
KEGG Pathways (20)
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Apelin signaling pathway
- Autophagy - animal
- Circadian rhythm
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Glucagon signaling pathway
- Hypertrophic cardiomyopathy
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Non-alcoholic fatty liver disease
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Thermogenesis
- Tight junction
- mTOR signaling pathway
Active Molecules (282)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RITAVMQDGBJQJZ
|
6.6 | Ki | 33 | — | |
VGNKOJURPOHWJF
|
6.6 | Ki | 21 | — | |
ZMAJVXKEVISHMQ
|
6.6 | IC50 | 9 | — | |
VCLMLPXAUIQEEM
|
6.6 | IC50 | 7 | — | |
MLGGUGPIWDHBAI
|
6.5 | Ki | 33 | — | |
OOQJIJYKWXLQNC
|
6.5 | IC50 | 16 | Yes | |
GRRWNPDZXOTJNA
|
6.5 | IC50 | 2 | — | |
NHHQJBCNYHBUSI
|
6.5 | Kd | 220 | — | |
OYONTEXKYJZFHA
|
6.5 | Kd | 69 | Yes | |
GQLWKGVBOIYMTN
|
6.5 | Ki | 35 | — | |
GWJHMRBQEUHFOC
|
6.5 | Ki | 42 | — | |
IFPPYSWJNWHOLQ
|
6.5 | Ki | 52 | Yes | |
NEWAULHLLUCDPD
|
6.5 | Ki | 27 | — | |
OLVBAUVSICCWEJ
|
6.5 | Ki | 39 | — | |
PBCZSGKMGDDXIJ
|
6.5 | Kd | 68 | Yes | |
QBKUOOQFSVMDPB
|
6.5 | Ki | 31 | — | |
UPPGGRZNGRFDAU
|
6.5 | Ki | 21 | — | |
RYYNGWLOYLRZLK
|
6.5 | Kd | 45 | — | |
ALKJNCZNEOTEMP
|
6.4 | Kd | 55 | — | |
MUXSMSOGTBJZDC
|
6.4 | IC50 | 2 | — | |
AEYLJTAIDDIOBA
|
6.4 | Ki | 53 | — | |
AIQDZMUPVYDVLB
|
6.4 | Ki | 48 | — | |
BNLPAUPVSCPTDM
|
6.4 | Ki | 15 | — | |
DKSNLQYRZJKYOC
|
6.4 | Ki | 51 | — | |
FPQHXFMYXQZPSV
|
6.4 | Ki | 23 | — | |
FSWFKKQQSQHIRZ
|
6.4 | Ki | 10 | — | |
HJYHJYGXRBYDIG
|
6.4 | Ki | 23 | — | |
IAKGNUWZPSPEKU
|
6.4 | Ki | 19 | — | |
IFQICUARAXVEIQ
|
6.4 | Ki | 18 | — | |
JJGSOVIZOMZMCS
|
6.4 | Ki | 35 | — | |
JNXJKTXDSPWNRP
|
6.4 | Ki | 30 | — | |
JPOSFPUHBHRUAX
|
6.4 | Ki | 40 | Yes | |
MDJCUXFFMNEBHG
|
6.4 | Ki | 13 | — | |
MTYMWGNJKDHWGN
|
6.4 | Ki | 18 | — | |
MZDKLVOWGIOKTN
|
6.4 | Ki | 80 | — | |
UEIRKXUBXCSHJE
|
6.4 | Ki | 19 | — | |
WVFWTUJEHMVUBG
|
6.4 | Ki | 25 | — | |
XLFYOIVELARSKP
|
6.4 | Ki | 33 | — | |
YMIJUBCSOKSFRU
|
6.4 | Ki | 87 | — | |
GCQRNJUDAAOEJK
|
6.4 | Kd | 3 | — | |
TZPUNPWJLMOANL
|
6.4 | IC50 | 6 | — | |
NICPYYDKEPDTPW
|
6.4 | IC50 | 2 | — | |
YYLKKYCXAOBSRM
|
6.4 | Kd | 191 | — | |
JWBXEWFBXJNXBU
|
6.3 | IC50 | 4 | — | |
KOZFSFOOLUUIGY
|
6.3 | Kd | 88 | Yes | |
ZXOKHOODFVNZIC
|
6.3 | IC50 | 7 | — | |
BLQYVHBZHAISJM
|
6.3 | Ki | 54 | — | |
CTESJDQKVOEUOY
|
6.3 | Kd | 3 | — | |
DFMCXVONDDGQIY
|
6.3 | Ki | 66 | — | |
FDBPGAHVEGEARY
|
6.3 | Ki | 19 | — |