Target Details
| UniProt AC | Q13131 |
|---|---|
| Gene Symbol | PRKAA1 |
| Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16579 (AdenylateSensor) PF21147 (AMPK_alpha_AID) PF00069 (Pkinase) |
Summary
- Multi-target molecules 282
- Clinical molecules 27
- Avg pChEMBL 6.8
KEGG Pathways (20)
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Apelin signaling pathway
- Autophagy - animal
- Circadian rhythm
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Glucagon signaling pathway
- Hypertrophic cardiomyopathy
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Non-alcoholic fatty liver disease
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Thermogenesis
- Tight junction
- mTOR signaling pathway
Active Molecules (282)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WINHZLLDWRZWRT
|
7.5 | Kd | 201 | Yes | |
MRMDURIHTGUZQI
|
7.5 | IC50 | 7 | — | |
WDNAXOPVZIEECR
|
7.5 | IC50 | 11 | — | |
MWKSRKSEWLRPBL
|
7.4 | Kd | 1075 | — | |
KXPWWMPXNUOYOH
|
7.4 | Ki | 24 | — | |
VXYDJXMHISGSDA
|
7.4 | Ki | 59 | — | |
WDARYLSSWBWVCU
|
7.4 | Ki | 49 | — | |
ZKHDDJKHTPLPOQ
|
7.4 | Ki | 62 | — | |
JCVIFVYRMKVCDU
|
7.3 | Kd | 3 | — | |
QFWZHKHVYWARIP
|
7.3 | Kd | 3 | — | |
LOLPPWBBNUVNQZ
|
7.3 | Kd | 97 | Yes | |
RGNHKJWHFIPHIM
|
7.3 | Ki | 66 | — | |
NGFGTMFVWSDFPS
|
7.3 | IC50 | 32 | — | |
OFPXCBKYWWZZGT
|
7.2 | IC50 | 7 | — | |
WMXDIPVFXWNELM
|
7.2 | IC50 | 14 | Yes | |
HZPACYSNLOCDLW
|
7.2 | Ki | 48 | — | |
NZVDDFRUBIEKLV
|
7.2 | Ki | 20 | — | |
UDFDIIVNIYWXDM
|
7.2 | Ki | 74 | — | |
WINHZLLDWRZWRT
|
7.2 | Ki | 66 | — | |
ZGZVRPRSFXRGCF
|
7.2 | Ki | 76 | — | |
ZWVZORIKUNOTCS
|
7.2 | Ki | 69 | — | |
XKFTZKGMDDZMJI
|
7.2 | Kd | 64 | Yes | |
CSZAJEXPQFERTK
|
7.2 | IC50 | 10 | — | |
JGMADXMPAZATOC
|
7.1 | Kd | 3 | — | |
XUFLBSMTYMFOQH
|
7.1 | Ki | 43 | — | |
XZXHXSATPCNXJR
|
7.1 | Kd | 165 | Yes | |
QFVPMQJTUWDFKR
|
7.0 | Kd | 3 | — | |
MHRSBLMFDBDIOU
|
7.0 | IC50 | 3 | — | |
XHBVYDAKJHETMP
|
7.0 | IC50 | 24 | Yes | |
XLFNLJYGUOLEJS
|
7.0 | IC50 | 26 | — | |
AOBLBPWPSKBHSI
|
7.0 | Ki | 55 | — | |
CTNPALGJUAXMMC
|
7.0 | Kd | 151 | — | |
OWDRQHVEJIYVOI
|
7.0 | Ki | 47 | — | |
SBFPHSVZEXSHTL
|
7.0 | Ki | 62 | — | |
VUHZDNOPEVGHEO
|
7.0 | Ki | 29 | — | |
DOTGPNHGTYJDEP
|
7.0 | IC50 | 8 | — | |
IQUHNNUWFFXNMM
|
7.0 | IC50 | 2 | — | |
SLCNIAWQMQCAFR
|
7.0 | IC50 | 8 | — | |
LTLTUJCGZGVBTO
|
7.0 | Kd | 3 | — | |
CMWRPDHVGMHLSZ
|
6.9 | IC50 | 22 | — | |
ADMFLILDQJSEIK
|
6.9 | Ki | 72 | — | |
BPMMMRKHRUQAAY
|
6.9 | IC50 | 7 | — | |
BQPLWJRDSDNGNE
|
6.9 | Ki | 16 | — | |
FUMCKNCUEAQHCV
|
6.9 | Ki | 103 | — | |
HEUSUIRCBWROMH
|
6.9 | Ki | 64 | — | |
PCQMERRARZKTPW
|
6.9 | Ki | 68 | — | |
PROLIXHVRCJEFH
|
6.9 | Ki | 46 | — | |
QNUKRWAIZMBVCU
|
6.9 | Ki | 46 | — | |
MBTDIENWIYANIG
|
6.9 | IC50 | 5 | Yes | |
JRKYKAKARRYSSS
|
6.8 | IC50 | 14 | Yes |