Target Details
| UniProt AC | Q13131 |
|---|---|
| Gene Symbol | PRKAA1 |
| Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16579 (AdenylateSensor) PF21147 (AMPK_alpha_AID) PF00069 (Pkinase) |
Summary
- Multi-target molecules 282
- Clinical molecules 27
- Avg pChEMBL 6.8
KEGG Pathways (20)
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Apelin signaling pathway
- Autophagy - animal
- Circadian rhythm
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Glucagon signaling pathway
- Hypertrophic cardiomyopathy
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Non-alcoholic fatty liver disease
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Thermogenesis
- Tight junction
- mTOR signaling pathway
Active Molecules (282)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HKSZLNNOFSGOKW
|
9.5 | Ki | 118 | — | |
FJNHSBVZTQFKEF
|
9.0 | IC50 | 7 | — | |
JKGJLUCJLNJXKG
|
8.6 | IC50 | 7 | — | |
NWMPVMMGSHXANZ
|
8.5 | Ki | 58 | — | |
HKSZLNNOFSGOKW
|
8.4 | Kd | 408 | — | |
HKSZLNNOFSGOKW
|
8.4 | Kd | 213 | — | |
GCYXEGSPUDSZJY
|
8.4 | Ki | 82 | — | |
TVUWQDLBEOZVOU
|
8.4 | Ki | 41 | — | |
XFWUTMHVDGPWLH
|
8.4 | Ki | 75 | — | |
FCLPVPNWFDOVKL
|
8.4 | Ki | 11 | — | |
LYADGAGFYYXXIO
|
8.3 | IC50 | 82 | — | |
NOMBUNHXDWBICV
|
8.3 | Ki | 11 | — | |
AYCPARAPKDAOEN
|
8.3 | IC50 | 73 | — | |
JLWGOAGEDWMEBT
|
8.3 | IC50 | 10 | — | |
JLWGOAGEDWMEBT
|
8.3 | IC50 | 10 | — | |
OWRXHGAFWZFFCW
|
8.2 | Ki | 113 | — | |
CXYVYGXMFQSTKH
|
8.2 | IC50 | 7 | — | |
FLEAYYMORDPWAJ
|
8.1 | Ki | 90 | — | |
XRDMDDSSWUSOAX
|
8.1 | IC50 | 7 | — | |
FHQXLWCFSUSXBF
|
8.1 | Kd | 3 | — | |
WGWCRXQUBYJTRA
|
8.0 | Ki | 11 | — | |
NJPWCTYVEJIQBM
|
8.0 | Ki | 72 | — | |
OFIFLUFVENTCNZ
|
8.0 | IC50 | 11 | — | |
OZFFKOSQNBBYCA
|
8.0 | IC50 | 12 | — | |
UMTWTCVTRDYHQQ
|
7.9 | Ki | 56 | — | |
NXSJMRCTGYTSTK
|
7.9 | Kd | 200 | — | |
MJHBRTGGZYSCHJ
|
7.9 | Kd | 3 | — | |
GKPYSXKYDOSNMQ
|
7.8 | Kd | 3 | — | |
JQJNGAWEMYQJIQ
|
7.8 | Kd | 3 | — | |
OSVUGUHRKMMBSE
|
7.8 | Kd | 170 | — | |
WQUGCKCCOOBUNT
|
7.8 | IC50 | 7 | — | |
XKFTZKGMDDZMJI
|
7.8 | Ki | 56 | — | |
GLDSKRNGVVYJAB
|
7.7 | Kd | 16 | — | |
SGZZQKMOFHIDKW
|
7.7 | Kd | 13 | — | |
BSFNGHCTZDCQBF
|
7.7 | Ki | 93 | — | |
MVJMMLFMPWITEJ
|
7.7 | Ki | 110 | — | |
RYYNGWLOYLRZLK
|
7.7 | Ki | 104 | — | |
VPUNMIRZXILGLE
|
7.7 | Kd | 3 | — | |
QZCUYXGDXFPQEA
|
7.7 | IC50 | 7 | — | |
NTZCHZCFSJZAQG
|
7.7 | IC50 | 7 | — | |
RHWVKZPITKBHLD
|
7.7 | Kd | 3 | — | |
QZIZUCHLAKADOE
|
7.6 | Kd | 3 | — | |
JAMDNXUAYUHJLJ
|
7.6 | Ki | 40 | — | |
UIARLYUEJFELEN
|
7.6 | Kd | 289 | Yes | |
XYZNKCSDQRKAFR
|
7.6 | Ki | 53 | — | |
UEFCSGDOOJJXTN
|
7.6 | IC50 | 46 | — | |
QQWUGDVOUVUTOY
|
7.6 | Kd | 231 | Yes | |
CHTMRWQLNNRRFJ
|
7.5 | Ki | 70 | — | |
JCFJQIHDZHHMQT
|
7.5 | Ki | 42 | — | |
RJZDECGDCKOHBV
|
7.5 | Ki | 70 | — |