Target Details
| UniProt AC | Q09472 |
|---|---|
| Gene Symbol | EP300 |
| Protein Name | Histone acetyltransferase p300 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00439 (Bromodomain) PF09030 (Creb_binding) PF08214 (HAT_KAT11) PF02172 (KIX) PF23570 (PHD_P300) PF06001 (RING_CBP-p300) PF02135 (zf-TAZ) PF00569 (ZZ) |
Summary
- Multi-target molecules 320
- Clinical molecules 0
- Avg pChEMBL 7.05
KEGG Pathways (29)
- Adherens junction
- Cadherin signaling
- Cell cycle
- FoxO signaling pathway
- Glucagon signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human papillomavirus infection
- Huntington disease
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term potentiation
- Melanogenesis
- MicroRNAs in cancer
- Notch signaling pathway
- Pathways in cancer
- Polycomb repressive complex
- Prostate cancer
- Renal cell carcinoma
- TGF-beta signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- Viral carcinogenesis
- Viral life cycle - HIV-1
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (5)
Active Molecules (320)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KBMKSBWYOFXIAK
|
7.4 | IC50 | 2 | — | |
LAPRXOPCUZUWEX
|
7.3 | IC50 | 2 | — | |
VVOJECSTVKGBLZ
|
7.3 | IC50 | 3 | — | |
RCPJEOKKJODBRQ
|
7.3 | IC50 | 2 | — | |
BFTKDWYIRJGJCA
|
7.3 | IC50 | 3 | — | |
FQVXPGXSEMNATG
|
7.3 | IC50 | 2 | — | |
PGCBJOXPRLCONN
|
7.3 | IC50 | 2 | — | |
VUNIVHBJGHPCRI
|
7.3 | IC50 | 2 | — | |
FMIRMIPUPDECHV
|
7.3 | IC50 | 2 | — | |
PZMDZHITJJVGOE
|
7.3 | IC50 | 2 | — | |
KIRQWNADLAWJTG
|
7.2 | IC50 | 2 | — | |
BWEUTLKRALRPIQ
|
7.2 | IC50 | 2 | — | |
RIEJRXHPNFTDTB
|
7.2 | IC50 | 2 | — | |
BRDWGDCKTCQZHX
|
7.2 | IC50 | 2 | — | |
VRVJKILQRBSEAG
|
7.2 | IC50 | 3 | — | |
XVPFIRFAOOSQTK
|
7.2 | IC50 | 2 | — | |
RBKUMEDNCTZKKV
|
7.2 | IC50 | 2 | — | |
ZAEXPXKGBRISBD
|
7.2 | IC50 | 2 | — | |
VJAWCSZJCQCSII
|
7.2 | IC50 | 2 | — | |
QEBQWMOQSWEYPS
|
7.2 | IC50 | 2 | — | |
QKJJFWYEGUSNLI
|
7.2 | IC50 | 2 | — | |
PILQVLXEOYXKCX
|
7.2 | IC50 | 3 | — | |
RDONXGFGWSSFMY
|
7.1 | IC50 | 6 | — | |
MKHZYJVBJCVUJD
|
7.1 | IC50 | 3 | — | |
LDPBOBQZOFLMLU
|
7.1 | IC50 | 3 | — | |
RFOWAAZLTHLZHO
|
7.1 | IC50 | 2 | — | |
CYSITNKCPSLBOI
|
7.1 | IC50 | 2 | — | |
YZLHFVLRIDPTGT
|
7.1 | IC50 | 2 | — | |
WAMYZVOQTGAIAL
|
7.1 | IC50 | 2 | — | |
OMECDPIDDYPFQD
|
7.1 | IC50 | 2 | — | |
XGBNNEZVBIKAQY
|
7.1 | IC50 | 2 | — | |
LPEFXYUIOKMUCW
|
7.0 | IC50 | 2 | — | |
RAIPQLGDNRXVJX
|
7.0 | IC50 | 2 | — | |
ZJGMOHOOSGHFMJ
|
7.0 | IC50 | 2 | — | |
IFIMPCBCWYNSEK
|
7.0 | IC50 | 2 | — | |
ZXNRDVKXEACFMY
|
7.0 | IC50 | 2 | — | |
YZLHFVLRIDPTGT
|
7.0 | IC50 | 2 | — | |
AMNYDJDEGBTNSA
|
7.0 | IC50 | 2 | — | |
BAHQNJLZVVLSJW
|
7.0 | IC50 | 2 | — | |
MPTLMMCZHBKKSK
|
7.0 | IC50 | 2 | — | |
RYPHRIMKBWOBND
|
7.0 | IC50 | 2 | — | |
DYJWRRZUNKSBCH
|
7.0 | IC50 | 2 | — | |
FTTXUZIHQYKOBF
|
7.0 | IC50 | 2 | — | |
JIYPVUCBRQNICX
|
7.0 | Kd | 7 | — | |
VEDJDLCMIXFLOX
|
6.9 | IC50 | 2 | — | |
ZNIQPKLUCOYTFF
|
6.9 | IC50 | 2 | — | |
LCZQNVZZLYLCLI
|
6.9 | IC50 | 2 | — | |
NJRFQVLIBLFGSD
|
6.9 | IC50 | 2 | — | |
YSBDLHAKVVSCMY
|
6.9 | IC50 | 2 | — | |
NPRLPBVOWPMZCP
|
6.9 | IC50 | 2 | — |